RNASEL


Summary: This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ribonuclease LMIM:180435Ensembl:ENSG00000135828HGNC:HGNC:10050PA344181q25.3

GO terms in RNASEL


Term TypeEvidence TypeGO Term IDGO Des.
CCNDGO:0005575cellular_component
CCTASGO:0005759mitochondrial matrix
CCTASGO:0005829cytosol
CCIEAGO:0016363nuclear matrix
BPIEAGO:0006364rRNA processing
BPIEAGO:0006397mRNA processing
BPNASGO:0006468protein phosphorylation
BPIEAGO:0043488regulation of mRNA stability
BPIDAGO:0045071negative regulation of viral genome replication
BPIEAGO:0045444fat cell differentiation
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0051607defense response to virus
BPTASGO:0060337type I interferon signaling pathway
BPTASGO:0060338regulation of type I interferon-mediated signaling pathway
BPIEAGO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic
BPIEAGO:2001275positive regulation of glucose import in response to insulin stimulus
MFIDAGO:0003723RNA binding
MFNASGO:0004521endoribonuclease activity
MFIEAGO:0004672protein kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0019843rRNA binding
MFIEAGO:0043021ribonucleoprotein complex binding
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: RNASEL

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RNASEL


DatabasePathway IDPathway Des.
wikipathwaysWP615Senescence and Autophagy in Cancer
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-909733Interferon alpha/beta signaling
reactomeR-HSA-913531Interferon Signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD772BRD47703
iGMDRD579PF7502
iGMDRD427ABT7374
iGMDRD639YK 4-2791
iGMDRD316N9-Isopropyl-olomoucine2
iGMDRD193Fqi13
iGMDRD446LY 21832403
iGMDRD201SKI II2
iGMDRD297Austocystin D4
iGMDRD679Bistramide A3
iGMDRD255SB2250022
iGMDRD52Rotenone2
iGMDRD870BRD636102
iGMDRD577BIX012942
iGMDRD888Compound 441
iGMDRD562Navitoclax1
iGMDRD100Zebularine2
iGMDRD188Piperlongumine3
iGMDRD887Compound 23 citrate4
iGMDRD399Selumetinib3
iGMDRD23Gossypol1
iGMDRD64Parbendazole3
iGMDRD148Pifithrin-mu5
iGMDRD116CD4373
iGMDRD219Bax channel blocker1
iGMDRD901ELCPK3
iGMDRD123Isoevodiamine1
iGMDRD202Curcumin3
iGMDRD137Indisulam1
iGMDRD213SMR0000686502
iGMDRD434BMS-5369243
iGMDRD366PI-1033
iGMDRD414MST-3123
iGMDRD871BRD63681
iGMDRD82Quiflapon2
iGMDRD886Compound 1541A2
iGMDRD505Pevonedistat1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RNASEL

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