RNASEL
Summary: This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ribonuclease L | MIM:180435 | Ensembl:ENSG00000135828 | HGNC:HGNC:10050 | PA34418 | 1q25.3 |
GO terms in RNASEL
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | ND | GO:0005575 | cellular_component |
| CC | TAS | GO:0005759 | mitochondrial matrix |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0016363 | nuclear matrix |
| BP | IEA | GO:0006364 | rRNA processing |
| BP | IEA | GO:0006397 | mRNA processing |
| BP | NAS | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0043488 | regulation of mRNA stability |
| BP | IDA | GO:0045071 | negative regulation of viral genome replication |
| BP | IEA | GO:0045444 | fat cell differentiation |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0051607 | defense response to virus |
| BP | TAS | GO:0060337 | type I interferon signaling pathway |
| BP | TAS | GO:0060338 | regulation of type I interferon-mediated signaling pathway |
| BP | IEA | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic |
| BP | IEA | GO:2001275 | positive regulation of glucose import in response to insulin stimulus |
| MF | IDA | GO:0003723 | RNA binding |
| MF | NAS | GO:0004521 | endoribonuclease activity |
| MF | IEA | GO:0004672 | protein kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0019843 | rRNA binding |
| MF | IEA | GO:0043021 | ribonucleoprotein complex binding |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: RNASEL
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RNASEL
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-909733 | Interferon alpha/beta signaling |
| reactome | R-HSA-913531 | Interferon Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD427 | ABT737 | 4 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD297 | Austocystin D | 4 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD870 | BRD63610 | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD562 | Navitoclax | 1 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD887 | Compound 23 citrate | 4 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD148 | Pifithrin-mu | 5 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD219 | Bax channel blocker | 1 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD871 | BRD6368 | 1 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD505 | Pevonedistat | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RNASEL
CLASSFICATION
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