RNASEL

Summary: This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameribonuclease L
OMIM IDMIM:180435
Ensembl IDEnsembl:ENSG00000135828
HGNC IDHGNC:HGNC:10050
PHARMGKB IDPA34418
Map Location1q25.3

GO terms in RNASEL


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Term Type
Evidence Type
GO Term ID
GO Des.
CC ND GO:0005575 cellular_component
CC TAS GO:0005759 mitochondrial matrix
CC TAS GO:0005829 cytosol
CC IEA GO:0016363 nuclear matrix
BP IEA GO:0006364 rRNA processing
BP IEA GO:0006397 mRNA processing
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Gene expression in normal tissue: RNASEL

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 76undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 3BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 6UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 2

Gene-drug pathway distribution

Pathways in RNASEL


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Database
Pathway ID
Pathway Des.
wikipathways WP615 Senescence and Autophagy in Cancer
kegg hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
kegg hsa05160 Hepatitis C - Homo sapiens (human)
kegg hsa05164 Influenza A - Homo sapiens (human)
kegg hsa05168 Herpes simplex infection - Homo sapiens (human)
reactome R-HSA-1280215 Cytokine Signaling in Immune system
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD772 BRD4770 3
iGMDRD579 PF750 2
iGMDRD427 ABT737 4
iGMDRD639 YK 4-279 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RNASEL

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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