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iGMDRD100

Canonical SMILES: C1=CN(C(=O)N=C1)C2C(C(C(O2)CO)O)O

InChI: InChI=1S/C9H12N2O5/c12-4-5-6(13)7(14)8(16-5)11-3-1-2-10-9(11)15/h1-3,5-8,12-14H,4H2/t5-,6-,7-,8-/m1/s1

InChI Key: RPQZTTQVRYEKCR-WCTZXXKLSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Zebularine	CHEMBL504567	100016	DB03068	Alone	Small Molecule

Drug Class:

Carbohydrates Glycosides Heterocyclic Compounds Heterocyclic Compounds, 1-Ring Nucleic Acids, Nucleotides, and Nucleosides Nucleosides Pyrimidine Nucleosides Pyrimidines Ribonucleosides

Drug Targets:

cdd (P0ABF6)DNMT1

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
331	XIAP	3
27102	EIF2AK1	2
1105	CHD1	2
27125	AFF4	2
8019	BRD3	1
5027	P2RX7	3
10903	MTMR11	5
79054	TRPM8	3
10221	TRIB1	4
8444	DYRK3	3
10987	COPS5	6
9261	MAPKAPK2	4
4751	NEK2	1
5933	RBL1	2
7161	TP73	3
840	CASP7	3
114801	TMEM200A	4
4168	MCF2	2
2956	MSH6	7
2339	FNTA	3
3708	ITPR1	4
1520	CTSS	5
9706	ULK2	1
817	CAMK2D	3
7272	TTK	4
3757	KCNH2	4
4750	NEK1	3
23097	CDK19	7
8289	ARID1A	2
26511	CHIC2	2
8573	CASK	4
5934	RBL2	3
2335	FN1	3
4928	NUP98	1
79092	CARD14	2
3431	SP110	4
4352	MPL	5
6938	TCF12	2
2475	MTOR	2
1263	PLK3	5
9475	ROCK2	6
6597	SMARCA4	2
5916	RARG	1
3326	HSP90AB1	1
10395	DLC1	1
5133	PDCD1	3
843	CASP10	3
7444	VRK2	2
390502	SERPINA2	4
53944	CSNK1G1	4
56776	FMN2	3
5079	PAX5	1
64783	RBM15	4
10892	MALT1	5
4313	MMP2	4
23235	SIK2	4
10863	ADAM28	3
4170	MCL1	4
1136	CHRNA3	3
23213	SULF1	2
1272	CNTN1	3
9641	IKBKE	3
5218	CDK14	3
3066	HDAC2	3
10142	AKAP9	3
6732	SRPK1	1
2241	FER	2
1404	HAPLN1	2
57172	CAMK1G	3
22821	RASA3	3
84299	MIEN1	4
140469	MYO3B	3
54822	TRPM7	2
202374	STK32A	3
112858	TP53RK	2
1387	CREBBP	1
11329	STK38	3
5756	TWF1	3
7555	CNBP	2
5467	PPARD	3
5788	PTPRC	4
23225	NUP210	6
4283	CXCL9	3
7133	TNFRSF1B	2
10178	TENM1	2
51755	CDK12	3
5966	REL	2
85021	REPS1	3
3604	TNFRSF9	2
29998	BICRA	3
8295	TRRAP	3
2977	GUCY1A2	2
5899	RALB	4
7373	COL14A1	2
7173	TPO	5
5314	PKHD1	2
55294	FBXW7	5
8784	TNFRSF18	1
641	BLM	1
64324	NSD1	3
55728	N4BP2	2
10006	ABI1	6
54477	PLEKHA5	3
22861	NLRP1	2
284521	OR2L13	1
4301	AFDN	3
5743	PTGS2	3
5607	MAP2K5	2
57396	CLK4	2
5900	RALGDS	4
342977	NANOS3	3
256646	NUTM1	2
1540	CYLD	4
7025	NR2F1	2
2051	EPHB6	2
9693	RAPGEF2	3
222484	LNX2	5
6256	RXRA	2
3714	JAG2	2
3556	IL1RAP	2
329	BIRC2	1
2688	GH1	3
26353	HSPB8	3
22806	IKZF3	4
10342	TFG	2
166614	DCLK2	1
7416	VDAC1	3
4005	LMO2	1
22984	PDCD11	5
6041	RNASEL	2
5468	PPARG	2
200576	PIKFYVE	1
80351	TNKS2	3
1437	CSF2	2
8313	AXIN2	3
6091	ROBO1	5
199699	DAND5	3
10188	TNK2	4
83990	BRIP1	3
3688	ITGB1	6
9098	USP6	1
284217	LAMA1	2
269	AMHR2	4
7424	VEGFC	4
55681	SCYL2	4
2045	EPHA7	2
140901	STK35	3
23405	DICER1	3
238	ALK	5
375449	MAST4	4
983	CDK1	3
6850	SYK	2
8643	PTCH2	3
26750	RPS6KC1	3
7486	WRN	2
23191	CYFIP1	5
5573	PRKAR1A	3
23387	SIK3	2
783	CACNB2	5
5580	PRKCD	4
4140	MARK3	2
29760	BLNK	3
8714	ABCC3	6
5286	PIK3C2A	3
25989	ULK3	4
8215	DVL1P1	2
1973	EIF4A1	3
8859	STK19	2
6464	SHC1	4
659	BMPR2	2
6098	ROS1	2
9472	AKAP6	1
54437	SEMA5B	3
3667	IRS1	2
51433	ANAPC5	2
80243	PREX2	3
8945	BTRC	3
83903	HASPIN	3
8148	TAF15	2
575	ADGRB1	3
5924	RASGRF2	4
2734	GLG1	3
9564	BCAR1	2
4058	LTK	2
7010	TEK	2
7533	YWHAH	4
23152	CIC	3
7867	MAPKAPK3	6
2066	ERBB4	2
904	CCNT1	4
5327	PLAT	2
5863	RGL2	2
79442	LRRC2	3
10413	YAP1	2
2201	FBN2	2
7184	HSP90B1	5
10062	NR1H3	2
5108	PCM1	1
23048	FNBP1	2
5336	PLCG2	2
9874	TLK1	3
58508	KMT2C	3
2099	ESR1	2
6092	ROBO2	3
4088	SMAD3	3
4602	MYB	1
4855	NOTCH4	4
25836	NIPBL	2
8218	CLTCL1	3
397	ARHGDIB	1
356	FASLG	3
114788	CSMD3	2
3000	GUCY2D	3
2263	FGFR2	5
4086	SMAD1	1
7249	TSC2	4
65243	ZFP69B	2
105	ADARB2	2
85481	PSKH2	1
863	CBFA2T3	3
1102	RCBTB2	2
55437	STRADB	2
2309	FOXO3	3
4921	DDR2	2
2177	FANCD2	4
55589	BMP2K	3
136332	LRGUK	2
5650	KLK7	5
7175	TPR	2
80205	CHD9	4
3718	JAK3	3
23365	ARHGEF12	3
57578	UNC79	6
4437	MSH3	1
23269	MGA	2
7994	KAT6A	2
2175	FANCA	3
23469	PHF3	1
6654	SOS1	9
672	BRCA1	2
2668	GDNF	3
5727	PTCH1	4
285220	EPHA6	2
51366	UBR5	6
3426	CFI	5
23678	SGK3	6
5297	PI4KA	7
10926	DBF4	2
10535	RNASEH2A	2
56997	COQ8A	2
57144	PAK5	4
340533	NEXMIF	3
286133	SCARA5	5
9972	NUP153	3
3562	IL3	3
92335	STRADA	3
3720	JARID2	2
1514	CTSL	4
5034	P4HB	2
26524	LATS2	3
2318	FLNC	5
57154	SMURF1	2
2030	SLC29A1	1
675	BRCA2	3
7075	TIE1	2
157680	VPS13B	2
841	CASP8	2
4609	MYC	1
64333	ARHGAP9	3
11064	CNTRL	2
90956	ADCK2	1
2624	GATA2	2
5789	PTPRD	2
8021	NUP214	2
90427	BMF	2
26278	SACS	5
894	CCND2	2
6776	STAT5A	2
51265	CDKL3	2
51701	NLK	2
6446	SGK1	4
5747	PTK2	1
2189	FANCG	3
5156	PDGFRA	3
5187	PER1	5
375056	MIA3	4
27330	RPS6KA6	2
3949	LDLR	3
203102	ADAM32	6
673	BRAF	2
57082	KNL1	7
84630	TTBK1	2
1981	EIF4G1	2
1213	CLTC	4
1769	DNAH8	3
23532	PRAME	2
4863	NPAT	4
8924	HERC2	4
120892	LRRK2	6
89795	NAV3	3
6095	RORA	4
57507	ZNF608	3
84441	MAML2	6
7301	TYRO3	3
7468	NSD2	2
8029	CUBN	2
5128	CDK17	3
23118	TAB2	3
9113	LATS1	2
5294	PIK3CG	5
9321	TRIP11	2
10253	SPRY2	1
4853	NOTCH2	3
23049	SMG1	4
8312	AXIN1	3
5728	PTEN	7
1487	CTBP1	3
7030	TFE3	1
2316	FLNA	3
5595	MAPK3	3
1316	KLF6	3
55120	FANCL	1
4914	NTRK1	7
667	DST	2
115701	ALPK2	1
660	BMX	3
83666	PARP9	3
5347	PLK1	6
352909	DNAAF3	9
2648	KAT2A	1
1950	EGF	4
177	AGER	4
658	BMPR1B	3
3899	AFF3	1
7273	TTN	1
91807	MYLK3	2
79834	PEAK1	2
5582	PRKCG	3
7465	WEE1	3
6789	STK4	2
23332	CLASP1	3
7454	WAS	2
23389	MED13L	1
8028	MLLT10	3
2277	VEGFD	2
29959	NRBP1	5
54904	NSD3	3
387	RHOA	2
9372	ZFYVE9	3
10249	GLYAT	2
8821	INPP4B	3
221895	JAZF1	5
8805	TRIM24	5
5532	PPP3CB	2
22843	PPM1E	1
286151	FBXO43	4
1662	DDX10	2
23305	ACSL6	1
1643	DDB2	2
54738	FEV	3
558	AXL	4
7248	TSC1	2
332	BIRC5	4
57680	CHD8	2
64764	CREB3L2	3
10111	RAD50	2
100124696	TEC	1
5395	PMS2	2
55289	ACOXL	6
9659	PDE4DIP	2
4000	LMNA	3
6093	ROCK1	1
5335	PLCG1	2
2776	GNAQ	2
5927	KDM5A	3
5587	PRKD1	1
55007	FAM118A	2
1719	DHFR	1
5583	PRKCH	6
900	CCNG1	6
57448	BIRC6	1
2131	EXT1	3
7099	TLR4	3
7227	TRPS1	2
79837	PIP4K2C	2
3709	ITPR2	2
6778	STAT6	2
4067	LYN	4
65267	WNK3	5
3552	IL1A	5
5932	RBBP8	5
3977	LIFR	7
84072	HORMAD1	2
170685	NUDT10	4
11076	TPPP	1
182	JAG1	1
2122	MECOM	3
3662	IRF4	3
1760	DMPK	4
5087	PBX1	3
3815	KIT	1
4974	OMG	5
4217	MAP3K5	2
1209	CLPTM1	5
63923	TNN	3
862	RUNX1T1	4
7403	KDM6A	2
54790	TET2	1
7508	XPC	4
2258	FGF13	3
4302	MLLT6	4
5586	PKN2	2
4205	MEF2A	2
55959	SULF2	1
9878	TOX4	6
3716	JAK1	2
57120	GOPC	3
3480	IGF1R	4
79728	PALB2	2
2651	GCNT2	3
11086	ADAM29	3
374	AREG	1
2261	FGFR3	2
2073	ERCC5	4
84446	BRSK1	2
581	BAX	1
55746	NUP133	4
8321	FZD1	6
4763	NF1	1
55791	LRIF1	4
494551	WEE2	3
65975	STK33	3
440270	GOLGA8B	2
5288	PIK3C2G	2
4286	MITF	3
57096	RPGRIP1	2
94	ACVRL1	2
4593	MUSK	4
2280	FKBP1A	3
4629	MYH11	6
23683	PRKD3	4
10048	RANBP9	5
699	BUB1	2
4193	MDM2	7
6868	ADAM17	3
23112	TNRC6B	2
83732	RIOK1	2
3895	KTN1	2
1499	CTNNB1	1
56155	TEX14	2
167359	NIM1K	4
2904	GRIN2B	6
5970	RELA	3
1488	CTBP2	3
5590	PRKCZ	2

Gene in drug-gene network: Network Plot

Models in Zebularine

SITE

DATATYPES

CLASSFICATION

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