BMF
Summary: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606266 Ensembl IDEnsembl:ENSG00000104081 HGNC IDHGNC:HGNC:24132 PHARMGKB IDPA134893658 Map Location15q15.1 | |||||
GO terms in BMF
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0001669 | acrosomal vesicle |
| CC | TAS | GO:0005741 | mitochondrial outer membrane |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0016459 | myosin complex |
| BP | TAS | GO:0001844 | protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
Gene expression in normal tissue: BMF
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BMF
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members |
| reactome | R-HSA-114452 | Activation of BH3-only proteins |
| reactome | R-HSA-139910 | Activation of BMF and translocation to mitochondria |
| reactome | R-HSA-5357801 | Programmed Cell Death |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BMF
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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