BMF
Summary: The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Bcl2 modifying factor | MIM:606266 | Ensembl:ENSG00000104081 | HGNC:HGNC:24132 | PA134893658 | 15q15.1 |
GO terms in BMF
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0001669 | acrosomal vesicle |
| CC | TAS | GO:0005741 | mitochondrial outer membrane |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0016459 | myosin complex |
| BP | TAS | GO:0001844 | protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| BP | IDA | GO:0010507 | negative regulation of autophagy |
| BP | ISS | GO:0032464 | positive regulation of protein homooligomerization |
| BP | IDA | GO:0034644 | cellular response to UV |
| BP | IMP | GO:0043065 | positive regulation of apoptotic process |
| BP | IDA | GO:0043276 | anoikis |
| BP | ISS | GO:0090200 | positive regulation of release of cytochrome c from mitochondria |
| BP | TAS | GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: BMF
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BMF
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-111453 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members |
| reactome | R-HSA-114452 | Activation of BH3-only proteins |
| reactome | R-HSA-139910 | Activation of BMF and translocation to mitochondria |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| netpath | Pathway_TCR | TCR |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD887 | Compound 23 citrate | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BMF
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