iGMDRD270

Canonical SMILES: CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C

InChI: InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1

InChI Key: PMATZTZNYRCHOR-CGLBZJNRSA-N

Standard NameCHEMBLPubchem CIDKEGG Drug IDDRUGBANK IDDrug StatusDrug targets (TTD)Drug Type
CiclosporinCHEMBL160 5284370D00184DB00091AloneDNC001177Small Molecule

Drug Class:

Amino Acids, Peptides, and ProteinsAnti-Infective AgentsAnti-Inflammatory AgentsAnti-inflammatory Agents, MiscellaneousAntifungal AgentsAntineoplastic and Immunomodulating AgentsAntirheumatic AgentsBCRP/ABCG2 InhibitorsBSEP/ABCB11 InhibitorsCalcineurin Inhibitor ImmunosuppressantCalcineurin InhibitorsCombined Inhibitors of CYP3A4 and P-glycoproteinCombined Inhibitors of CYP3A4 and P-glycoprotein (Moderate)CyclosporinsCytochrome P-450 CYP3A InhibitorsCytochrome P-450 CYP3A SubstratesCytochrome P-450 CYP3A4 InhibitorsCytochrome P-450 CYP3A4 Inhibitors (moderate)Cytochrome P-450 CYP3A4 SubstratesCytochrome P-450 CYP3A5 SubstratesCytochrome P-450 CYP3A7 SubstratesCytochrome P-450 Enzyme InducersCytochrome P-450 Enzyme InhibitorsDermatologicalsEnzyme InhibitorsImmunologic FactorsImmunosuppressive AgentsMacrocyclic CompoundsOphthalmologicalsP-glycoprotein/ABCB1 InducersP-glycoprotein/ABCB1 InhibitorsP-glycoprotein/ABCB1 SubstratesPeptidesPeptides, CyclicPolycyclic CompoundsSensory Organs



Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
331XIAP3
1147CHUK2
7837PXDN5
21ABCA33
6774STAT32
29101SSU723
2956MSH62
2339FNTA3
9706ULK21
5295PIK3R11
8289ARID1A2
4928NUP982
79092CARD142
10395DLC11
5133PDCD11
10863ADAM282
3320HSP90AA12
3066HDAC22
7253TSHR3
3841KPNA53
55534MAML31
604BCL62
202374STK32A2
29998BICRA1
5159PDGFRB2
55351STK32B2
55294FBXW74
641BLM2
7852CXCR43
54477PLEKHA51
55819RNF1301
2051EPHB62
8549LGR51
3714JAG22
7416VDAC11
200576PIKFYVE3
6091ROBO12
2736GLI22
269AMHR23
22858ICK2
2064ERBB23
85443DCLK32
83983TSSK63
4294MAP3K102
1456CSNK1G32
92ACVR2A2
4605MYBL23
5924RASGRF23
4058LTK2
898CCNE11
23152CIC3
2050EPHB43
2272FHIT5
2066ERBB41
1647GADD45A3
9874TLK13
6794STK111
25836NIPBL3
2329FMO44
5585PKN13
105ADARB22
85481PSKH23
8874ARHGEF72
51086TNNI3K2
9088PKMYT13
2309FOXO32
7038TG2
984CDK11B2
6795AURKC3
23269MGA2
5727PTCH12
5606MAP2K31
50615IL21R2
2318FLNC3
10565ARFGEF13
57154SMURF12
2030SLC29A13
607BCL91
157680VPS13B3
4609MYC5
8021NUP2141
90427BMF3
5156PDGFRA3
375056MIA32
93627TBCK2
3949LDLR2
203102ADAM322
83452RAB33B1
8924HERC22
9113LATS14
5979RET1
1977EIF4E2
23049SMG13
10010TANK2
5728PTEN2
115701ALPK21
79834PEAK12
8667EIF3H2
53904MYO3A1
54861SNRK1
5532PPP3CB1
10595ERN23
1643DDB22
54738FEV3
5291PIK3CB3
57680CHD83
2690GHR3
55289ACOXL2
283455KSR25
5335PLCG12
2130EWSR13
3579CXCR23
55007FAM118A2
79837PIP4K2C2
1906EDN12
5915RARB2
23512SUZ123
8536CAMK13
5087PBX12
3815KIT3
7403KDM6A3
3716JAK11
79728PALB22
23092ARHGAP263
5287PIK3C2B2
3679ITGA71
10048RANBP93
23112TNRC6B1
27255CNTN62
5602MAPK102
2904GRIN2B3
5590PRKCZ2

Gene in drug-gene network: Network Plot

Models in Ciclosporin

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