CHD8
Summary: This gene encodes a member of the chromodomain-helicase-DNA binding protein family, which is characterized by a SNF2-like domain and two chromatin organization modifier domains. The encoded protein also contains brahma and kismet domains, which are common to the subfamily of chromodomain-helicase-DNA binding proteins to which this protein belongs. This gene has been shown to function in several processes that include transcriptional regulation, epigenetic remodeling, promotion of cell proliferation, and regulation of RNA synthesis. Allelic variants of this gene are associated with autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| chromodomain helicase DNA binding protein 8 | MIM:610528 | Ensembl:ENSG00000100888 | HGNC:HGNC:20153 | PA134957052 | 14q11.2 |
GO terms in CHD8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0002039 | p53 binding |
| MF | IMP | GO:0003677 | DNA binding |
| MF | IMP | GO:0003678 | DNA helicase activity |
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IDA | GO:0008013 | beta-catenin binding |
| MF | IDA | GO:0008094 | DNA-dependent ATPase activity |
| MF | IDA | GO:0035064 | methylated histone binding |
| MF | ISS | GO:0042393 | histone binding |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IMP | GO:0007420 | brain development |
| BP | IDA | GO:0030178 | negative regulation of Wnt signaling pathway |
| BP | IEA | GO:0032508 | DNA duplex unwinding |
| BP | IMP | GO:0043044 | ATP-dependent chromatin remodeling |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045945 | positive regulation of transcription by RNA polymerase III |
| BP | IMP | GO:0048565 | digestive tract development |
| BP | IDA | GO:0060070 | canonical Wnt signaling pathway |
| BP | IDA | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0071339 | MLL1 complex |
Gene expression in normal tissue: CHD8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CHD8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex |
| wikipathways | WP428 | Wnt Signaling Pathway |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD121 | GMX1778 | 5 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD103 | SN-38 | 5 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD505 | Pevonedistat | 11 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD330 | BRD4132 | 1 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD171 | Pemetrexed | 4 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD562 | Navitoclax | 5 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD427 | ABT737 | 5 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD446 | LY 2183240 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CHD8
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