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iGMDRD483

Canonical SMILES: CN(C)CCCNC1=NC(=NC2=CC=CC=C21)CN3CCN(CC3)C(C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

InChI: InChI=1S/C31H36Cl2N6/c1-37(2)17-5-16-34-31-27-6-3-4-7-28(27)35-29(36-31)22-38-18-20-39(21-19-38)30(23-8-12-25(32)13-9-23)24-10-14-26(33)15-11-24/h3-4,6-15,30H,5,16-22H2,1-2H3,(H,34,35,36)

InChI Key: NCAJLQDPTZBGJV-UHFFFAOYSA-N

Standard Name	Pubchem CID	Drug Status	Drug Type
SCH-529074	12001900	Alone	Small Molecule

Drug Targets:

TP53

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
3696	ITGB8	3
64901	RANBP17	1
8999	CDKL2	3
8019	BRD3	1
471	ATIC	2
79848	CSPP1	2
7837	PXDN	1
132	ADK	1
2986	GUCY2F	1
5546	PRCC	2
150465	TTL	3
399	RHOH	3
3708	ITPR1	2
347365	ITIH6	3
3845	KRAS	2
4750	NEK1	6
5295	PIK3R1	2
6563	SLC14A1	2
8289	ARID1A	4
80070	ADAMTS20	1
701	BUB1B	2
51231	VRK3	3
25778	DSTYK	3
2335	FN1	3
2475	MTOR	2
1263	PLK3	3
7764	ZNF217	2
9530	BAG4	3
390502	SERPINA2	3
64783	RBM15	3
10863	ADAM28	4
6598	SMARCB1	3
7253	TSHR	3
5298	PI4KB	6
84299	MIEN1	1
114783	LMTK3	2
1387	CREBBP	2
8106	PABPN1	3
55023	PHIP	4
51755	CDK12	3
8295	TRRAP	5
11122	PTPRT	1
6722	SRF	3
27148	STK36	3
222484	LNX2	3
1591	CYP24A1	3
3714	JAG2	3
10188	TNK2	1
11169	WDHD1	9
4216	MAP3K4	3
2736	GLI2	1
83990	BRIP1	3
51804	SIX4	3
7037	TFRC	3
238	ALK	3
399979	SNX19	6
834	CASP1	3
29775	CARD10	3
338322	NLRP10	3
25989	ULK3	3
8859	STK19	3
6464	SHC1	4
6037	RNASE3	3
2778	GNAS	3
130497	OSR1	3
472	ATM	2
5165	PDK3	3
575	ADGRB1	3
8038	ADAM12	2
1123	CHN1	2
7867	MAPKAPK3	3
2201	FBN2	3
5129	CDK18	6
284656	EPHA10	1
83694	RPS6KL1	2
861	RUNX1	2
27347	STK39	2
4173	MCM4	3
4855	NOTCH4	2
25836	NIPBL	1
26281	FGF20	3
4086	SMAD1	1
9639	ARHGEF10	1
7249	TSC2	3
84075	FSCB	2
9088	PKMYT1	3
7038	TG	5
6197	RPS6KA3	3
65125	WNK1	5
136332	LRGUK	5
4436	MSH2	2
652	BMP4	3
676	BRDT	1
54106	TLR9	3
2000	ELF4	3
57578	UNC79	2
4026	LPP	1
3643	INSR	3
57551	TAOK1	1
54658	UGT1A1	1
2668	GDNF	3
9252	RPS6KA5	2
5606	MAP2K3	5
5578	PRKCA	2
440275	EIF2AK4	6
1198	CLK3	3
2187	FANCB	3
5290	PIK3CA	2
92335	STRADA	6
6046	BRD2	3
4293	MAP3K9	2
85366	MYLK2	6
2318	FLNC	3
607	BCL9	1
7075	TIE1	3
1017	CDK2	3
4609	MYC	1
1459	CSNK2A2	2
8013	NR4A3	3
4684	NCAM1	1
26278	SACS	2
3635	INPP5D	6
23604	DAPK2	3
6872	TAF1	9
203102	ADAM32	2
673	BRAF	6
6011	GRK1	2
23532	PRAME	1
6502	SKP2	1
89795	NAV3	1
6095	RORA	5
9321	TRIP11	3
8312	AXIN1	3
55521	TRIM36	2
5728	PTEN	1
5595	MAPK3	2
667	DST	1
115701	ALPK2	1
1950	EGF	2
177	AGER	3
1676	DFFA	6
9344	TAOK2	1
8522	GAS7	1
10257	ABCC4	3
387	RHOA	4
79012	CAMKV	3
8821	INPP4B	2
4297	KMT2A	1
558	AXL	1
7248	TSC1	2
2932	GSK3B	3
57680	CHD8	1
9021	SOCS3	2
10111	RAD50	2
5927	KDM5A	4
4215	MAP3K3	3
23139	MAST2	1
22982	DIP2C	2
2157	F8	1
53335	BCL11A	2
3709	ITPR2	4
8899	PRPF4B	2
84254	CAMKK1	3
8428	STK24	2
6300	MAPK12	3
3516	RBPJ	3
3977	LIFR	2
7112	TMPO	3
23512	SUZ12	6
2122	MECOM	2
2065	ERBB3	1
2074	ERCC6	2
7403	KDM6A	2
4439	MSH5	3
2534	FYN	1
30849	PIK3R4	2
4299	AFF1	2
11086	ADAM29	4
2261	FGFR3	1
84446	BRSK1	2
57697	FANCM	3
138474	TAF1L	3
55791	LRIF1	3
1840	DTX1	3
5288	PIK3C2G	2
5287	PIK3C2B	2
4193	MDM2	2
2444	FRK	2

Gene in drug-gene network: Network Plot

Models in SCH-529074

SITE

DATATYPES

CLASSFICATION

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