AXIN1


Summary: This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
axin 1MIM:603816Ensembl:ENSG00000103126HGNC:HGNC:903PA2519516p13.3

GO terms in AXIN1


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0001934positive regulation of protein phosphorylation
BPIEAGO:0006915apoptotic process
BPNASGO:0010800positive regulation of peptidyl-threonine phosphorylation
BPTASGO:0016055Wnt signaling pathway
BPTASGO:0030111regulation of Wnt signaling pathway
BPIDAGO:0030178negative regulation of Wnt signaling pathway
BPNASGO:0031398positive regulation of protein ubiquitination
BPIDAGO:0032147activation of protein kinase activity
BPNASGO:0033138positive regulation of peptidyl-serine phosphorylation
BPTASGO:0033146regulation of intracellular estrogen receptor signaling pathway
BPIDAGO:0034622cellular protein-containing complex assembly
BPIEAGO:0043547positive regulation of GTPase activity
BPICGO:0045732positive regulation of protein catabolic process
BPIDAGO:0045732positive regulation of protein catabolic process
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPISSGO:0046330positive regulation of JNK cascade
BPIMPGO:0051443positive regulation of ubiquitin-protein transferase activity
BPICGO:0060070canonical Wnt signaling pathway
BPIMPGO:0090090negative regulation of canonical Wnt signaling pathway
BPTASGO:0090263positive regulation of canonical Wnt signaling pathway
BPTASGO:1904885beta-catenin destruction complex assembly
BPTASGO:1904886beta-catenin destruction complex disassembly
BPISSGO:2000060positive regulation of ubiquitin-dependent protein catabolic process
CCIDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIDAGO:0016328lateral plasma membrane
CCIDAGO:0030877beta-catenin destruction complex
CCISSGO:0031410cytoplasmic vesicle
CCIDAGO:0048471perinuclear region of cytoplasm
CCIDAGO:0071944cell periphery
MFIPIGO:0005515protein binding
MFIDAGO:0008013beta-catenin binding
MFIPIGO:0019899enzyme binding
MFISSGO:0019901protein kinase binding
MFIEAGO:0030159receptor signaling complex scaffold activity
MFIPIGO:0031625ubiquitin protein ligase binding
MFIDAGO:0032947protein-containing complex scaffold activity
MFIMPGO:0032947protein-containing complex scaffold activity
MFTASGO:0035591signaling adaptor activity
MFIPIGO:0042802identical protein binding
MFISSGO:0042802identical protein binding
MFISSGO:0042803protein homodimerization activity
MFIPIGO:0046332SMAD binding
MFISSGO:0070016armadillo repeat domain binding
MFIPIGO:0070411I-SMAD binding

Gene expression in normal tissue: AXIN1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AXIN1


DatabasePathway IDPathway Des.
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05217Basal cell carcinoma - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
pidbetacatenin_deg_pathwayDegradation of beta catenin
pidmyc_pathwayC-MYC pathway
pidncadherinpathwayN-cadherin signaling events
pidps1pathwayPresenilin action in Notch and Wnt signaling
pidtgfbrpathwayTGF-beta receptor signaling
pidwnt_canonical_pathwayCanonical Wnt signaling pathway
netpathPathway_WntWnt
wikipathwaysWP2064Neural Crest Differentiation
wikipathwaysWP2773Degradation of beta-catenin by the destruction complex
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP2864Apoptosis-related network due to altered Notch3 in ovarian cancer
wikipathwaysWP2870Extracellular vesicle-mediated signaling in recipient cells
wikipathwaysWP363Wnt Signaling Pathway
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP3664Regulation of Wnt-B-catenin Signaling by Small Molecule Compounds
wikipathwaysWP3680Association Between Physico-Chemical Features and Toxicity Associated Pathways
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4105Transcriptional regulation by RUNX1
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer
wikipathwaysWP428Wnt Signaling Pathway
wikipathwaysWP710DNA Damage Response (only ATM dependent)
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-195253Degradation of beta-catenin by the destruction complex
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-196299Beta-catenin phosphorylation cascade
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-4641257Degradation of AXIN
reactomeR-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membrane
reactomeR-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membrane
reactomeR-HSA-4791275Signaling by WNT in cancer
reactomeR-HSA-4839735AXIN mutants destabilize the destruction complex, activating WNT signaling
reactomeR-HSA-4839743phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
reactomeR-HSA-4839744truncated APC mutants destabilize the destruction complex
reactomeR-HSA-4839748AMER1 mutants destabilize the destruction complex
reactomeR-HSA-5339716Misspliced GSK3beta mutants stabilize beta-catenin
reactomeR-HSA-5358747S33 mutants of beta-catenin aren't phosphorylated
reactomeR-HSA-5358749S37 mutants of beta-catenin aren't phosphorylated
reactomeR-HSA-5358751S45 mutants of beta-catenin aren't phosphorylated
reactomeR-HSA-5358752T41 mutants of beta-catenin aren't phosphorylated
reactomeR-HSA-5467337APC truncation mutants have impaired AXIN binding
reactomeR-HSA-5467340AXIN missense mutants destabilize the destruction complex
reactomeR-HSA-5467348Truncations of AMER1 destabilize the destruction complex
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8931987RUNX1 regulates estrogen receptor mediated transcription
reactomeR-HSA-8939211ESR-mediated signaling
reactomeR-HSA-8939256RUNX1 regulates transcription of genes involved in WNT signaling
reactomeR-HSA-9006931Signaling by Nuclear Receptors
reactomeR-HSA-9018519Estrogen-dependent gene expression
biocartagsk3pathwayinactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
biocartahespathwaysegmentation clock
biocartapitx2pathwaymulti-step regulation of transcription by pitx2
biocartawntpathwaywnt signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD84Lovastatin acid3
iGMDRD79Gemcitabine4
iGMDRD405PIK-753
iGMDRD522ML-0301
iGMDRD424Tamatinib2
iGMDRD116CD4372
iGMDRD150RITA3
iGMDRD351GW843682X2
iGMDRD499PDMP3
iGMDRD57Chloropentafluorobenzene3
iGMDRD85Ursolic acid4
iGMDRD435BI-25363
iGMDRD883CIL55A1
iGMDRD945ML2145
iGMDRD123Isoevodiamine2
iGMDRD211(1S,3R)-RSL31
iGMDRD121GMX17786
iGMDRD137Indisulam6
iGMDRD103SN-382
iGMDRD434BMS-5369243
iGMDRD289Parthenolide8
iGMDRD105Triptolide2
iGMDRD662JQ-12
iGMDRD872BRD71375
iGMDRD871BRD63685
iGMDRD322FK 8665
iGMDRD263AACOCF32
iGMDRD246NPC265
iGMDRD505Pevonedistat3
iGMDRD886Compound 1541A1
iGMDRD300Tozasertib2
iGMDRD772BRD47702
iGMDRD889Compound 7d-cis2
iGMDRD599Salermide5
iGMDRD126Tipifarnib5
iGMDRD483SCH-5290743
iGMDRD427ABT7375
iGMDRD61Kinetin riboside4
iGMDRD446LY 21832401
iGMDRD634SCHEMBL26080413
iGMDRD466Chaetocin4
iGMDRD394BX-7953
iGMDRD679Bistramide A3
iGMDRD8024-methylfasudil2
iGMDRD138PX 125
iGMDRD474Avrainvillamide2
iGMDRD187BRD98764
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD318PAC-15
iGMDRD171Pemetrexed3
iGMDRD562Navitoclax6
iGMDRD398Sepantronium2
iGMDRD74Idarubicin1
iGMDRD887Compound 23 citrate2
iGMDRD188Piperlongumine5
iGMDRD100Zebularine3
iGMDRD451Serdemetan2
iGMDRD23Gossypol4
iGMDRD356PNU-746543
iGMDRD64Parbendazole2
iGMDRD60Quinoclamine2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AXIN1

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