AXIN1


Summary: This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameaxin 1
OMIM IDMIM:603816
PHARMGKB IDPA25195
Map Location16p13.3

GO terms in AXIN1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0001934 positive regulation of protein phosphorylation
BP IEA GO:0006915 apoptotic process
BP NAS GO:0010800 positive regulation of peptidyl-threonine phosphorylation
BP TAS GO:0016055 Wnt signaling pathway
BP TAS GO:0030111 regulation of Wnt signaling pathway
BP IDA GO:0030178 negative regulation of Wnt signaling pathway
Showing 1 to 6 of 46 rows rows per page

Gene expression in normal tissue: AXIN1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined46Apoptosis regulation3Cell cycle2One carbon pool by folate1p53 pathway1Biosynthesis of secondary metabolites1Mitosis1Chromatin other1Purine metabolism1Ferroptosis1

Pathways in AXIN1


Loading, please wait...
Database
Pathway ID
Pathway Des.
kegg hsa04310 Wnt signaling pathway - Homo sapiens (human)
kegg hsa04390 Hippo signaling pathway - Homo sapiens (human)
kegg hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegg hsa04934 Cushing,s syndrome - Homo sapiens (human)
kegg hsa05165 Human papillomavirus infection - Homo sapiens (human)
kegg hsa05200 Pathways in cancer - Homo sapiens (human)
Showing 1 to 6 of 78 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD84 Lovastatin acid 3
iGMDRD79 Gemcitabine 4
iGMDRD405 PIK-75 3
iGMDRD522 ML-030 1
Showing 1 to 4 of 61 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AXIN1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​