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iGMDRD351

Canonical SMILES: COC1=C(C=C2C(=C1)N=CN2C3=CC(=C(S3)C(=O)N)OCC4=CC=CC=C4C(F)(F)F)OC

InChI: InChI=1S/C22H18F3N3O4S/c1-30-16-7-14-15(8-17(16)31-2)28(11-27-14)19-9-18(20(33-19)21(26)29)32-10-12-5-3-4-6-13(12)22(23,24)25/h3-9,11H,10H2,1-2H3,(H2,26,29)

InChI Key: JSKUWFIZUALZLX-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	Drug Status	Drug Type
GW843682X	CHEMBL514499	9826310	Alone	Small Molecule

Drug Targets:

PLK1 PLK3

Drug Pathways:

Cell cycle

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
3696	ITGB8	1
64901	RANBP17	2
27102	EIF2AK1	2
1105	CHD1	2
4854	NOTCH3	4
7514	XPO1	2
8999	CDKL2	2
5027	P2RX7	2
10903	MTMR11	3
7837	PXDN	4
10641	NPRL2	3
8444	DYRK3	3
21	ABCA3	6
132	ADK	2
5933	RBL1	2
7421	VDR	1
8915	BCL10	3
6319	SCD	1
8476	CDC42BPA	3
7750	ZMYM2	1
4926	NUMA1	4
11183	MAP4K5	6
79947	DHDDS	4
2956	MSH6	1
2200	FBN1	3
57679	ALS2	5
10783	NEK6	3
4477	MSMB	2
9706	ULK2	3
51347	TAOK3	1
23097	CDK19	3
6563	SLC14A1	5
2100	ESR2	6
6351	CCL4	3
80070	ADAMTS20	7
701	BUB1B	6
5934	RBL2	2
2335	FN1	2
4928	NUP98	1
79092	CARD14	2
53616	ADAM22	3
3431	SP110	6
2161	F12	3
6938	TCF12	3
2475	MTOR	3
83942	TSSK1B	4
150209	AIFM3	1
3551	IKBKB	2
81035	COLEC12	1
3326	HSP90AB1	3
4036	LRP2	2
2176	FANCC	1
10395	DLC1	1
353345	GPR141	5
7942	TFEB	3
56776	FMN2	1
64783	RBM15	6
51684	SUFU	3
6598	SMARCB1	2
4170	MCL1	3
10142	AKAP9	2
7253	TSHR	2
23310	NCAPD3	5
5298	PI4KB	3
2241	FER	2
6318	SERPINB4	1
1545	CYP1B1	3
7080	NKX2-1	2
51199	NIN	3
28231	SLCO4A1	2
1387	CREBBP	2
8106	PABPN1	3
5756	TWF1	8
10454	TAB1	1
2043	EPHA4	3
55023	PHIP	3
5579	PRKCB	3
31	ACACA	3
51755	CDK12	2
79858	NEK11	4
57472	CNOT6	3
10438	C1D	4
23617	TSSK2	2
5396	PRRX1	2
5159	PDGFRB	1
7173	TPO	6
4851	NOTCH1	6
139378	ADGRG4	2
89910	UBE3B	3
10295	BCKDK	4
2033	EP300	3
6927	HNF1A	5
8784	TNFRSF18	2
4001	LMNB1	6
9578	CDC42BPB	5
641	BLM	2
4361	MRE11	3
1454	CSNK1E	3
3227	HOXC11	3
1453	CSNK1D	1
6390	SDHB	6
54477	PLEKHA5	1
57670	KIAA1549	3
440279	UNC13C	2
4301	AFDN	1
342667	STAC2	3
342977	NANOS3	1
256646	NUTM1	3
1540	CYLD	2
1880	GPR183	4
122011	CSNK1A1L	1
3927	LASP1	6
6256	RXRA	4
8852	AKAP4	1
2242	FES	1
3091	HIF1A	5
3645	INSRR	3
8313	AXIN2	3
6091	ROBO1	2
51343	FZR1	1
5330	PLCB2	3
23255	MTCL1	1
730249	ACOD1	3
80129	CCDC170	3
10188	TNK2	4
10217	CTDSPL	2
2908	NR3C1	3
83990	BRIP1	4
51804	SIX4	1
5601	MAPK9	3
3688	ITGB1	1
6928	HNF1B	3
4194	MDM4	2
27324	TOX3	3
284217	LAMA1	2
269	AMHR2	1
207	AKT1	3
23405	DICER1	4
1277	COL1A1	4
85443	DCLK3	4
65266	WNK4	3
6850	SYK	1
57476	GRAMD1B	2
65217	PCDH15	6
3916	LAMP1	3
834	CASP1	3
9020	MAP3K14	1
7486	WRN	3
29775	CARD10	5
440730	TRIM67	3
6416	MAP2K4	1
9759	HDAC4	2
6709	SPTAN1	6
1973	EIF4A1	3
10087	COL4A3BP	5
50488	MINK1	5
5591	PRKDC	1
6464	SHC1	3
7166	TPH1	6
8515	ITGA10	2
2778	GNAS	6
3667	IRS1	1
80243	PREX2	1
472	ATM	6
1009	CDH11	3
28996	HIPK2	2
575	ADGRB1	2
2734	GLG1	3
84433	CARD11	6
6792	CDKL5	3
54986	ULK4	4
1123	CHN1	6
1496	CTNNA2	3
5450	POU2AF1	4
2066	ERBB4	4
7681	MKRN3	2
5863	RGL2	3
9319	TRIP13	3
2201	FBN2	7
1029	CDKN2A	2
7184	HSP90B1	2
10062	NR1H3	3
5108	PCM1	3
9794	MAML1	3
284656	EPHA10	3
57523	NYNRIN	8
9874	TLK1	3
28514	DLL1	2
5834	PYGB	1
58508	KMT2C	8
6092	ROBO2	3
4088	SMAD3	3
27086	FOXP1	4
79058	ASPSCR1	2
4855	NOTCH4	1
6794	STK11	1
57194	ATP10A	3
4857	NOVA1	9
25836	NIPBL	4
57410	SCYL1	2
4292	MLH1	1
54498	SMOX	2
2263	FGFR2	4
4086	SMAD1	1
2133	EXT3	5
9639	ARHGEF10	3
7249	TSC2	2
1019	CDK4	1
7409	VAV1	2
11213	IRAK3	2
9967	THRAP3	2
863	CBFA2T3	1
8874	ARHGEF7	1
1555	CYP2B6	4
55034	MOCOS	3
5600	MAPK11	2
3572	IL6ST	2
5077	PAX3	5
6197	RPS6KA3	3
55589	BMP2K	6
65125	WNK1	4
57591	MRTFA	1
136332	LRGUK	5
652	BMP4	3
5650	KLK7	2
7175	TPR	4
8997	KALRN	2
4437	MSH3	3
6795	AURKC	3
2071	ERCC3	3
3643	INSR	3
57551	TAOK1	2
5610	EIF2AK2	2
23469	PHF3	2
4089	SMAD4	4
170692	ADAMTS18	2
6654	SOS1	1
7204	TRIO	2
23373	CRTC1	2
5727	PTCH1	5
285220	EPHA6	3
51366	UBR5	6
3417	IDH1	3
23678	SGK3	3
10926	DBF4	1
5578	PRKCA	5
4214	MAP3K1	2
440275	EIF2AK4	2
9972	NUP153	2
3239	HOXD13	6
92335	STRADA	3
4293	MAP3K9	4
26524	LATS2	5
85366	MYLK2	3
2318	FLNC	3
10565	ARFGEF1	5
57154	SMURF1	2
675	BRCA2	7
7075	TIE1	2
640	BLK	1
157680	VPS13B	5
2735	GLI1	3
4609	MYC	3
8013	NR4A3	3
10461	MERTK	2
51321	AMZ2	5
7297	TYK2	4
26278	SACS	2
894	CCND2	1
283629	TSSK4	3
5462	POU5F1B	1
1440	CSF3	2
29951	PDZRN4	2
51701	NLK	4
6446	SGK1	3
79759	ZNF668	2
833	CARS	3
3635	INPP5D	1
7917	BAG6	4
375056	MIA3	3
93627	TBCK	1
3949	LDLR	1
7015	TERT	3
7153	TOP2A	1
57082	KNL1	4
1981	EIF4G1	3
1213	CLTC	3
84879	MFSD2A	3
1769	DNAH8	2
22976	PAXIP1	3
3315	HSPB1	3
83452	RAB33B	2
5598	MAPK7	4
8924	HERC2	6
120892	LRRK2	8
6095	RORA	11
29844	TFPT	2
84441	MAML2	3
7301	TYRO3	3
5205	ATP8B1	2
8178	ELL	3
1024	CDK8	2
7849	PAX8	6
9321	TRIP11	3
9451	EIF2AK3	2
4853	NOTCH2	6
9509	ADAMTS2	1
23396	PIP5K1C	6
8312	AXIN1	2
23476	BRD4	3
5728	PTEN	2
5595	MAPK3	2
7155	TOP2B	2
1869	E2F1	3
22883	CLSTN1	2
115701	ALPK2	4
284086	NEK8	1
5305	PIP4K2A	1
23542	MAPK8IP2	2
352909	DNAAF3	2
6770	STAR	3
2188	FANCF	3
2324	FLT4	3
2648	KAT2A	2
3678	ITGA5	3
7273	TTN	2
91807	MYLK3	2
79834	PEAK1	3
6789	STK4	1
23332	CLASP1	4
7059	THBS3	2
79012	CAMKV	5
3161	HMMR	2
55561	CDC42BPG	5
2046	EPHA8	3
8821	INPP4B	2
10243	GPHN	2
1662	DDX10	2
23305	ACSL6	3
344905	ATP13A5	6
5588	PRKCQ	3
10076	PTPRU	7
7248	TSC1	3
5923	RASGRF1	3
2690	GHR	1
100124696	TEC	3
7094	TLN1	1
5609	MAP2K7	5
9659	PDE4DIP	2
3624	INHBA	3
5927	KDM5A	4
5587	PRKD1	3
5583	PRKCH	3
2321	FLT1	2
23139	MAST2	2
22982	DIP2C	3
2157	F8	1
5506	PPP1R3A	2
1627	DBN1	3
6778	STAT6	3
51562	MBIP	2
5932	RBBP8	2
23512	SUZ12	5
8536	CAMK1	3
2122	MECOM	3
5925	RB1	6
4217	MAP3K5	3
1209	CLPTM1	2
2065	ERBB3	3
5324	PLAG1	3
10420	TESK2	4
2534	FYN	3
7508	XPC	3
55959	SULF2	1
3716	JAK1	2
79728	PALB2	3
23092	ARHGAP26	5
51135	IRAK4	8
10494	STK25	3
4915	NTRK2	5
11086	ADAM29	3
142	PARP1	4
9262	STK17B	3
2261	FGFR3	5
23072	HECW1	2
2073	ERCC5	3
55422	ZNF331	3
1013	CDH15	2
3092	HIP1	4
8321	FZD1	3
4763	NF1	3
57697	FANCM	2
63893	UBE2O	2
6886	TAL1	2
94	ACVRL1	2
2044	EPHA5	2
4593	MUSK	1
4629	MYH11	3
10048	RANBP9	5
6868	ADAM17	3
55193	PBRM1	1
2178	FANCE	1
27255	CNTN6	5
57699	CPNE5	3
1499	CTNNB1	4
2444	FRK	4
5602	MAPK10	5
2892	GRIA3	2
1436	CSF1R	3
1795	DOCK3	2
2904	GRIN2B	4
5624	PROC	4
5970	RELA	4

Gene in drug-gene network: Network Plot

Models in GW843682X

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.