MDM4


Summary: This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
MDM4, p53 regulatorMIM:602704Ensembl:ENSG00000198625HGNC:HGNC:6974PA307191q32.1

GO terms in MDM4


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
MFTASGO:0008270zinc ion binding
MFIPIGO:0019899enzyme binding
MFTASGO:0061630ubiquitin protein ligase activity
CCIDAGO:0005634nucleus
CCNASGO:0005634nucleus
CCTASGO:0005654nucleoplasm
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPTASGO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
BPIEPGO:0008283cell proliferation
BPTASGO:0008285negative regulation of cell proliferation
BPIEAGO:0016567protein ubiquitination
BPTASGO:0016579protein deubiquitination
BPIEPGO:0030330DNA damage response, signal transduction by p53 class mediator
BPIMPGO:0042177negative regulation of protein catabolic process
BPIEAGO:0043066negative regulation of apoptotic process
BPIEPGO:0045023G0 to G1 transition
BPIEPGO:0050821protein stabilization
BPIDAGO:0065003protein-containing complex assembly
BPIEAGO:0071157negative regulation of cell cycle arrest
BPIEPGO:0071456cellular response to hypoxia
BPTASGO:1901796regulation of signal transduction by p53 class mediator

Gene expression in normal tissue: MDM4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MDM4


DatabasePathway IDPathway Des.
pidp53regulationpathwayp53 pathway
kegghsa04115p53 signaling pathway - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
wikipathwaysWP2261Signaling Pathways in Glioblastoma
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559580Oxidative Stress Induced Senescence
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2559585Oncogene Induced Senescence
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-6804757Regulation of TP53 Degradation
reactomeR-HSA-6804760Regulation of TP53 Activity through Methylation
reactomeR-HSA-6806003Regulation of TP53 Expression and Degradation
reactomeR-HSA-69541Stabilization of p53
reactomeR-HSA-69563p53-Dependent G1 DNA Damage Response
reactomeR-HSA-69580p53-Dependent G1/S DNA damage checkpoint
reactomeR-HSA-69615G1/S DNA Damage Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953897Cellular responses to external stimuli

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD705Nakiterpiosin3
iGMDRD6AM-5802
iGMDRD77Itraconazole3
iGMDRD318PAC-13
iGMDRD138PX 122
iGMDRD137Indisulam4
iGMDRD255SB2250022
iGMDRD64Parbendazole3
iGMDRD399Selumetinib2
iGMDRD286Nsc 6328391
iGMDRD188Piperlongumine2
iGMDRD871BRD63682
iGMDRD398Sepantronium2
iGMDRD506Fedratinib3
iGMDRD329Merck603
iGMDRD781Sirolimus3
iGMDRD405PIK-752
iGMDRD307Manumycin A1
iGMDRD433Lexibulin2
iGMDRD940MDM2/MDMX inhibitor2
iGMDRD512nutlin 31
iGMDRD123Isoevodiamine3
iGMDRD901ELCPK3
iGMDRD341Triacsin c3
iGMDRD446LY 21832404
iGMDRD193Fqi13
iGMDRD61Kinetin riboside4
iGMDRD237ABT-7515
iGMDRD351GW843682X2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MDM4

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