MDM4


Summary: This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:602704
PHARMGKB IDPA30719
Map Location1q32.1

GO terms in MDM4


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF TAS GO:0008270 zinc ion binding
MF IPI GO:0019899 enzyme binding
MF TAS GO:0061630 ubiquitin protein ligase activity
CC IDA GO:0005634 nucleus
CC NAS GO:0005634 nucleus
Showing 1 to 6 of 22 rows rows per page

Gene expression in normal tissue: MDM4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MDM4


Loading, please wait...
Database
Pathway ID
Pathway Des.
pid p53regulationpathway p53 pathway
kegg hsa04115 p53 signaling pathway - Homo sapiens (human)
kegg hsa05206 MicroRNAs in cancer - Homo sapiens (human)
wikipathways WP2261 Signaling Pathways in Glioblastoma
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-212436 Generic Transcription Pathway
Showing 1 to 6 of 28 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD705 Nakiterpiosin 3
iGMDRD6 AM-580 2
iGMDRD77 Itraconazole 3
iGMDRD318 PAC-1 3
Showing 1 to 4 of 29 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MDM4

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​