iGMDRD318
| Standard Name | CHEMBL | Pubchem CID | Drug Status | Drug Type |
|---|---|---|---|---|
| PAC-1 | CHEMBL591429 | 6753380 | Alone | Small Molecule |
Drug Pathways:
Apoptosis regulationDrug-model tissue-cancer distribution: Bubble Plot
Drug-gene pathway enrichments
Drug-gene GO enrichments
Drug-Gene: Aster Plot
| Gene ID | Gene Name | Model Num. |
|---|---|---|
| 331 | XIAP | 2 |
| 27125 | AFF4 | 1 |
| 4854 | NOTCH3 | 5 |
| 8999 | CDKL2 | 2 |
| 6664 | SOX11 | 6 |
| 7074 | TIAM1 | 2 |
| 997 | CDC34 | 3 |
| 79848 | CSPP1 | 2 |
| 7837 | PXDN | 7 |
| 10641 | NPRL2 | 1 |
| 21 | ABCA3 | 3 |
| 6581 | SLC22A3 | 2 |
| 132 | ADK | 8 |
| 3383 | ICAM1 | 5 |
| 6774 | STAT3 | 2 |
| 5933 | RBL1 | 2 |
| 6195 | RPS6KA1 | 1 |
| 7421 | VDR | 2 |
| 2986 | GUCY2F | 3 |
| 2048 | EPHB2 | 6 |
| 5546 | PRCC | 1 |
| 2956 | MSH6 | 3 |
| 2200 | FBN1 | 1 |
| 4303 | FOXO4 | 3 |
| 57679 | ALS2 | 3 |
| 150465 | TTL | 3 |
| 1520 | CTSS | 1 |
| 9149 | DYRK1B | 1 |
| 347365 | ITIH6 | 1 |
| 5295 | PIK3R1 | 1 |
| 55215 | FANCI | 6 |
| 8289 | ARID1A | 1 |
| 80070 | ADAMTS20 | 3 |
| 3939 | LDHA | 1 |
| 51231 | VRK3 | 3 |
| 11193 | WBP4 | 1 |
| 25778 | DSTYK | 3 |
| 2335 | FN1 | 9 |
| 4928 | NUP98 | 4 |
| 79092 | CARD14 | 3 |
| 53616 | ADAM22 | 3 |
| 9760 | TOX | 5 |
| 3431 | SP110 | 4 |
| 2161 | F12 | 3 |
| 9263 | STK17A | 1 |
| 81035 | COLEC12 | 3 |
| 3326 | HSP90AB1 | 1 |
| 7764 | ZNF217 | 2 |
| 10395 | DLC1 | 4 |
| 3069 | HDLBP | 3 |
| 3209 | HOXA13 | 1 |
| 6657 | SOX2 | 3 |
| 53944 | CSNK1G1 | 3 |
| 1786 | DNMT1 | 4 |
| 3320 | HSP90AA1 | 2 |
| 7253 | TSHR | 6 |
| 8749 | ADAM18 | 2 |
| 2241 | FER | 2 |
| 341676 | NEK5 | 1 |
| 5154 | PDGFA | 3 |
| 140469 | MYO3B | 2 |
| 604 | BCL6 | 1 |
| 7048 | TGFBR2 | 3 |
| 54822 | TRPM7 | 3 |
| 943 | TNFRSF8 | 1 |
| 577 | ADGRB3 | 4 |
| 1813 | DRD2 | 9 |
| 1387 | CREBBP | 2 |
| 10454 | TAB1 | 3 |
| 8844 | KSR1 | 2 |
| 2885 | GRB2 | 6 |
| 5788 | PTPRC | 3 |
| 23225 | NUP210 | 2 |
| 56164 | STK31 | 4 |
| 5579 | PRKCB | 6 |
| 11200 | CHEK2 | 6 |
| 31 | ACACA | 1 |
| 10178 | TENM1 | 3 |
| 8558 | CDK10 | 4 |
| 26576 | SRPK3 | 1 |
| 5396 | PRRX1 | 1 |
| 5159 | PDGFRB | 5 |
| 7373 | COL14A1 | 5 |
| 5314 | PKHD1 | 3 |
| 51512 | GTSE1 | 3 |
| 139378 | ADGRG4 | 2 |
| 89910 | UBE3B | 2 |
| 974 | CD79B | 7 |
| 6927 | HNF1A | 2 |
| 54567 | DLL4 | 1 |
| 8784 | TNFRSF18 | 1 |
| 10746 | MAP3K2 | 3 |
| 23522 | KAT6B | 5 |
| 55728 | N4BP2 | 6 |
| 1453 | CSNK1D | 1 |
| 7852 | CXCR4 | 6 |
| 57670 | KIAA1549 | 3 |
| 22861 | NLRP1 | 2 |
| 837 | CASP4 | 1 |
| 440279 | UNC13C | 2 |
| 4610 | MYCL | 6 |
| 2115 | ETV1 | 2 |
| 10272 | FSTL3 | 1 |
| 84033 | OBSCN | 1 |
| 25937 | WWTR1 | 1 |
| 342977 | NANOS3 | 1 |
| 152137 | CCDC50 | 1 |
| 131096 | KCNH8 | 3 |
| 1880 | GPR183 | 1 |
| 3621 | ING1 | 3 |
| 9693 | RAPGEF2 | 1 |
| 6418 | SET | 1 |
| 1586 | CYP17A1 | 3 |
| 3714 | JAG2 | 6 |
| 329 | BIRC2 | 2 |
| 4300 | MLLT3 | 1 |
| 8396 | PIP4K2B | 3 |
| 2242 | FES | 6 |
| 4005 | LMO2 | 1 |
| 22984 | PDCD11 | 5 |
| 8313 | AXIN2 | 2 |
| 6091 | ROBO1 | 2 |
| 2042 | EPHA3 | 3 |
| 1050 | CEBPA | 1 |
| 116986 | AGAP2 | 1 |
| 5330 | PLCB2 | 3 |
| 4216 | MAP3K4 | 3 |
| 6198 | RPS6KB1 | 1 |
| 1936 | EEF1D | 3 |
| 5601 | MAPK9 | 3 |
| 57761 | TRIB3 | 1 |
| 3303 | HSPA1A | 1 |
| 4194 | MDM4 | 3 |
| 27324 | TOX3 | 3 |
| 284217 | LAMA1 | 2 |
| 83931 | STK40 | 1 |
| 2045 | EPHA7 | 5 |
| 1992 | SERPINB1 | 6 |
| 1277 | COL1A1 | 2 |
| 375449 | MAST4 | 5 |
| 2064 | ERBB2 | 6 |
| 983 | CDK1 | 1 |
| 6850 | SYK | 6 |
| 57476 | GRAMD1B | 3 |
| 8643 | PTCH2 | 3 |
| 993 | CDC25A | 4 |
| 54899 | PXK | 2 |
| 29775 | CARD10 | 1 |
| 23387 | SIK3 | 3 |
| 4294 | MAP3K10 | 1 |
| 7525 | YES1 | 1 |
| 1452 | CSNK1A1 | 6 |
| 5286 | PIK3C2A | 1 |
| 6709 | SPTAN1 | 4 |
| 8215 | DVL1P1 | 3 |
| 50488 | MINK1 | 1 |
| 2068 | ERCC2 | 5 |
| 8859 | STK19 | 2 |
| 5568 | PRKACG | 3 |
| 6037 | RNASE3 | 1 |
| 9472 | AKAP6 | 3 |
| 3685 | ITGAV | 5 |
| 6917 | TCEA1 | 6 |
| 3667 | IRS1 | 8 |
| 80243 | PREX2 | 3 |
| 8945 | BTRC | 6 |
| 2580 | GAK | 2 |
| 139285 | AMER1 | 8 |
| 3418 | IDH2 | 3 |
| 8148 | TAF15 | 1 |
| 28996 | HIPK2 | 2 |
| 2521 | FUS | 3 |
| 3397 | ID1 | 1 |
| 4087 | SMAD2 | 1 |
| 9096 | TBX18 | 5 |
| 9564 | BCAR1 | 5 |
| 11344 | TWF2 | 6 |
| 8038 | ADAM12 | 2 |
| 6792 | CDKL5 | 2 |
| 54986 | ULK4 | 2 |
| 1123 | CHN1 | 2 |
| 1496 | CTNNA2 | 4 |
| 7010 | TEK | 3 |
| 5450 | POU2AF1 | 1 |
| 898 | CCNE1 | 1 |
| 2272 | FHIT | 4 |
| 2066 | ERBB4 | 3 |
| 904 | CCNT1 | 2 |
| 5327 | PLAT | 5 |
| 51517 | NCKIPSD | 4 |
| 1029 | CDKN2A | 1 |
| 139728 | PNCK | 6 |
| 9361 | LONP1 | 1 |
| 27436 | EML4 | 2 |
| 284656 | EPHA10 | 3 |
| 57523 | NYNRIN | 12 |
| 5336 | PLCG2 | 5 |
| 10018 | BCL2L11 | 1 |
| 27347 | STK39 | 2 |
| 3932 | LCK | 1 |
| 648 | BMI1 | 6 |
| 6794 | STK11 | 8 |
| 2322 | FLT3 | 2 |
| 960 | CD44 | 1 |
| 2329 | FMO4 | 8 |
| 356 | FASLG | 3 |
| 4292 | MLH1 | 1 |
| 54498 | SMOX | 1 |
| 84513 | PLPP5 | 6 |
| 130399 | ACVR1C | 2 |
| 225689 | MAPK15 | 3 |
| 5585 | PKN1 | 3 |
| 1019 | CDK4 | 3 |
| 7409 | VAV1 | 2 |
| 65243 | ZFP69B | 5 |
| 124540 | MSI2 | 3 |
| 85481 | PSKH2 | 3 |
| 5604 | MAP2K1 | 3 |
| 8874 | ARHGEF7 | 6 |
| 10516 | FBLN5 | 1 |
| 9088 | PKMYT1 | 3 |
| 7422 | VEGFA | 3 |
| 5164 | PDK2 | 1 |
| 369 | ARAF | 1 |
| 57105 | CYSLTR2 | 1 |
| 57591 | MRTFA | 5 |
| 7495 | XBP1P1 | 1 |
| 6934 | TCF7L2 | 1 |
| 4436 | MSH2 | 1 |
| 50945 | TBX22 | 1 |
| 652 | BMP4 | 1 |
| 6035 | RNASE1 | 3 |
| 6535 | SLC6A8 | 1 |
| 162979 | ZNF296 | 1 |
| 5650 | KLK7 | 2 |
| 30012 | TLX3 | 1 |
| 5871 | MAP4K2 | 11 |
| 23365 | ARHGEF12 | 2 |
| 2081 | ERN1 | 3 |
| 84181 | CHD6 | 2 |
| 4026 | LPP | 1 |
| 8997 | KALRN | 6 |
| 4437 | MSH3 | 4 |
| 7994 | KAT6A | 6 |
| 3643 | INSR | 3 |
| 57111 | RAB25 | 1 |
| 23469 | PHF3 | 8 |
| 8288 | EPX | 3 |
| 6654 | SOS1 | 5 |
| 672 | BRCA1 | 5 |
| 11168 | PSIP1 | 3 |
| 835 | CASP2 | 1 |
| 5727 | PTCH1 | 8 |
| 285220 | EPHA6 | 5 |
| 546 | ATRX | 5 |
| 3426 | CFI | 3 |
| 2047 | EPHB1 | 2 |
| 7786 | MAP3K12 | 2 |
| 10926 | DBF4 | 6 |
| 64840 | PORCN | 1 |
| 57144 | PAK5 | 3 |
| 340533 | NEXMIF | 2 |
| 3702 | ITK | 2 |
| 440275 | EIF2AK4 | 2 |
| 9972 | NUP153 | 3 |
| 50615 | IL21R | 1 |
| 84823 | LMNB2 | 3 |
| 5290 | PIK3CA | 1 |
| 1514 | CTSL | 3 |
| 4145 | MATK | 3 |
| 4293 | MAP3K9 | 3 |
| 253260 | RICTOR | 4 |
| 5045 | FURIN | 2 |
| 2318 | FLNC | 3 |
| 10565 | ARFGEF1 | 1 |
| 57154 | SMURF1 | 3 |
| 3458 | IFNG | 4 |
| 26166 | RGS22 | 5 |
| 607 | BCL9 | 2 |
| 10155 | TRIM28 | 3 |
| 1956 | EGFR | 1 |
| 8445 | DYRK2 | 5 |
| 640 | BLK | 2 |
| 157680 | VPS13B | 4 |
| 2735 | GLI1 | 3 |
| 3065 | HDAC1 | 4 |
| 64750 | SMURF2 | 2 |
| 3308 | HSPA4 | 6 |
| 5789 | PTPRD | 2 |
| 1326 | MAP3K8 | 6 |
| 5753 | PTK6 | 3 |
| 7297 | TYK2 | 5 |
| 896 | CCND3 | 2 |
| 29951 | PDZRN4 | 5 |
| 6776 | STAT5A | 1 |
| 5663 | PSEN1 | 3 |
| 5747 | PTK2 | 2 |
| 3635 | INPP5D | 1 |
| 8900 | CCNA1 | 4 |
| 23604 | DAPK2 | 1 |
| 7917 | BAG6 | 1 |
| 1544 | CYP1A2 | 9 |
| 93627 | TBCK | 7 |
| 56924 | PAK6 | 1 |
| 673 | BRAF | 1 |
| 1981 | EIF4G1 | 1 |
| 23532 | PRAME | 3 |
| 780 | DDR1 | 3 |
| 83452 | RAB33B | 2 |
| 57538 | ALPK3 | 3 |
| 6469 | SHH | 3 |
| 339345 | NANOS2 | 3 |
| 89795 | NAV3 | 2 |
| 79184 | BRCC3 | 2 |
| 6095 | RORA | 7 |
| 7301 | TYRO3 | 3 |
| 2113 | ETS1 | 2 |
| 5205 | ATP8B1 | 3 |
| 8029 | CUBN | 2 |
| 9113 | LATS1 | 2 |
| 8178 | ELL | 1 |
| 5979 | RET | 3 |
| 9321 | TRIP11 | 1 |
| 9451 | EIF2AK3 | 6 |
| 6615 | SNAI1 | 1 |
| 9509 | ADAMTS2 | 2 |
| 8621 | CDK13 | 6 |
| 23396 | PIP5K1C | 1 |
| 3654 | IRAK1 | 1 |
| 10010 | TANK | 4 |
| 8312 | AXIN1 | 5 |
| 10752 | CHL1 | 3 |
| 7030 | TFE3 | 4 |
| 100187828 | HBD | 6 |
| 22883 | CLSTN1 | 2 |
| 23281 | MTUS2 | 2 |
| 4004 | LMO1 | 1 |
| 3554 | IL1R1 | 2 |
| 23542 | MAPK8IP2 | 3 |
| 4317 | MMP8 | 1 |
| 6770 | STAR | 6 |
| 2188 | FANCF | 3 |
| 6146 | RPL22 | 3 |
| 6009 | RHEB | 3 |
| 2870 | GRK6 | 3 |
| 8301 | PICALM | 3 |
| 28954 | REM1 | 2 |
| 1445 | CSK | 4 |
| 8522 | GAS7 | 1 |
| 171023 | ASXL1 | 1 |
| 79834 | PEAK1 | 6 |
| 5582 | PRKCG | 2 |
| 995 | CDC25C | 4 |
| 6789 | STK4 | 2 |
| 2119 | ETV5 | 6 |
| 7454 | WAS | 2 |
| 7036 | TFR2 | 6 |
| 55356 | SLC22A15 | 3 |
| 2277 | VEGFD | 2 |
| 8667 | EIF3H | 2 |
| 54904 | NSD3 | 4 |
| 9372 | ZFYVE9 | 3 |
| 10249 | GLYAT | 4 |
| 3207 | HOXA11 | 1 |
| 10595 | ERN2 | 3 |
| 344905 | ATP13A5 | 2 |
| 5588 | PRKCQ | 3 |
| 4297 | KMT2A | 8 |
| 51151 | SLC45A2 | 2 |
| 5291 | PIK3CB | 5 |
| 1493 | CTLA4 | 3 |
| 10076 | PTPRU | 3 |
| 3985 | LIMK2 | 3 |
| 332 | BIRC5 | 2 |
| 317 | APAF1 | 1 |
| 2041 | EPHA1 | 1 |
| 2317 | FLNB | 3 |
| 9021 | SOCS3 | 3 |
| 778 | CACNA1F | 1 |
| 53353 | LRP1B | 5 |
| 3181 | HNRNPA2B1 | 3 |
| 152110 | NEK10 | 3 |
| 9659 | PDE4DIP | 1 |
| 9201 | DCLK1 | 1 |
| 4000 | LMNA | 1 |
| 2049 | EPHB3 | 3 |
| 283455 | KSR2 | 4 |
| 6093 | ROCK1 | 3 |
| 2130 | EWSR1 | 3 |
| 2776 | GNAQ | 2 |
| 131890 | GRK7 | 1 |
| 4628 | MYH10 | 5 |
| 55007 | FAM118A | 3 |
| 5589 | PRKCSH | 5 |
| 1975 | EIF4B | 3 |
| 57448 | BIRC6 | 6 |
| 57007 | ACKR3 | 3 |
| 5681 | PSKH1 | 1 |
| 3717 | JAK2 | 3 |
| 22982 | DIP2C | 5 |
| 7227 | TRPS1 | 3 |
| 5506 | PPP1R3A | 6 |
| 1627 | DBN1 | 2 |
| 6778 | STAT6 | 3 |
| 8899 | PRPF4B | 4 |
| 4067 | LYN | 2 |
| 8550 | MAPKAPK5 | 3 |
| 1030 | CDKN2B | 1 |
| 3984 | LIMK1 | 2 |
| 3516 | RBPJ | 2 |
| 80216 | ALPK1 | 1 |
| 5932 | RBBP8 | 2 |
| 3977 | LIFR | 1 |
| 330 | BIRC3 | 7 |
| 4261 | CIITA | 6 |
| 4330 | MN1 | 4 |
| 84072 | HORMAD1 | 1 |
| 1455 | CSNK1G2 | 1 |
| 444 | ASPH | 5 |
| 7046 | TGFBR1 | 2 |
| 2122 | MECOM | 2 |
| 3662 | IRF4 | 2 |
| 51167 | CYB5R4 | 10 |
| 1760 | DMPK | 1 |
| 5925 | RB1 | 4 |
| 7113 | TMPRSS2 | 1 |
| 1515 | CTSV | 3 |
| 4893 | NRAS | 1 |
| 7069 | THRSP | 1 |
| 63923 | TNN | 1 |
| 3691 | ITGB4 | 2 |
| 7508 | XPC | 2 |
| 2258 | FGF13 | 3 |
| 4302 | MLLT6 | 3 |
| 7040 | TGFB1 | 3 |
| 3488 | IGFBP5 | 1 |
| 2011 | MARK2 | 2 |
| 51135 | IRAK4 | 2 |
| 55869 | HDAC8 | 8 |
| 4299 | AFF1 | 2 |
| 9935 | MAFB | 1 |
| 142 | PARP1 | 8 |
| 374 | AREG | 3 |
| 2261 | FGFR3 | 1 |
| 8711 | TNK1 | 4 |
| 4040 | LRP6 | 4 |
| 1013 | CDH15 | 3 |
| 3092 | HIP1 | 2 |
| 4763 | NF1 | 3 |
| 8814 | CDKL1 | 1 |
| 1994 | ELAVL1 | 6 |
| 4613 | MYCN | 1 |
| 5288 | PIK3C2G | 4 |
| 2044 | EPHA5 | 5 |
| 5287 | PIK3C2B | 3 |
| 23031 | MAST3 | 6 |
| 30811 | HUNK | 1 |
| 3265 | HRAS | 1 |
| 4193 | MDM2 | 1 |
| 2178 | FANCE | 3 |
| 29110 | TBK1 | 1 |
| 5885 | RAD21 | 9 |
| 3895 | KTN1 | 1 |
| 27151 | CPAMD8 | 2 |
| 5602 | MAPK10 | 6 |
| 1436 | CSF1R | 3 |
| 167359 | NIM1K | 2 |
| 11035 | RIPK3 | 6 |
| 5970 | RELA | 1 |
Gene in drug-gene network: Network Plot
Models in PAC-1
CLASSFICATION
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