TLX3
Summary: The protein encoded by this gene is an orphan homeobox protein that encodes a DNA-binding nuclear transcription factor. A translocation [t(5;14)(q35;q32)] involving this gene is associated with T-cell acute lymphoblastic leukemia (T-ALL) in children and young adults. [provided by RefSeq, Nov 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| T cell leukemia homeobox 3 | MIM:604640 | Ensembl:ENSG00000164438 | HGNC:HGNC:13532 | PA37797 | 5q35.1 |
GO terms in TLX3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0043565 | sequence-specific DNA binding |
| BP | IEA | GO:0001764 | neuron migration |
| BP | IEA | GO:0002087 | regulation of respiratory gaseous exchange by neurological system process |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0007417 | central nervous system development |
| BP | IEA | GO:0007585 | respiratory gaseous exchange |
| BP | IEA | GO:0045665 | negative regulation of neuron differentiation |
| BP | IEA | GO:0048665 | neuron fate specification |
| CC | IDA | GO:0005654 | nucleoplasm |
Gene expression in normal tissue: TLX3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TLX3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| wikipathways | WP2023 | Cell Differentiation - Index expanded |
| wikipathways | WP2029 | Cell Differentiation - Index |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD105 | Triptolide | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD210 | AC55649 | 3 |
| iGMDRD577 | BIX01294 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TLX3
CLASSFICATION
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