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iGMDRD105

Canonical SMILES: CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2O)O7)COC6=O)C

InChI: InChI=1S/C20H24O6/c1-8(2)18-13(25-18)14-20(26-14)17(3)5-4-9-10(7-23-15(9)21)11(17)6-12-19(20,24-12)16(18)22/h8,11-14,16,22H,4-7H2,1-3H3/t11-,12-,13-,14-,16+,17-,18-,19+,20+/m0/s1

InChI Key: DFBIRQPKNDILPW-CIVMWXNOSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Triptolide	CHEMBL463763	107985	DB12025	Alone	Small Molecule

Drug Class:

Alkylating Agents Antineoplastic Agents Antineoplastic Agents, Alkylating Antispermatogenic Agents Contraceptive Agents Contraceptive Agents, Male Ethers Ethers, Cyclic Hydrocarbons Hydrocarbons, Aromatic Hydrocarbons, Cyclic Immunologic Factors Immunosuppressive Agents Macrocyclic Compounds Noxae Polycyclic Compounds Polycyclic Hydrocarbons, Aromatic Reproductive Control Agents Terpenes Toxic Actions Tripterygium

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
331	XIAP	3
1147	CHUK	3
1105	CHD1	4
27125	AFF4	2
4854	NOTCH3	5
7514	XPO1	1
8999	CDKL2	3
5296	PIK3R2	2
79848	CSPP1	1
7837	PXDN	5
79054	TRPM8	3
1464	CSPG4	1
10641	NPRL2	1
23085	ERC1	3
6491	STIL	1
21	ABCA3	2
6581	SLC22A3	2
7750	ZMYM2	6
2048	EPHB2	3
2956	MSH6	2
2200	FBN1	3
57679	ALS2	2
57554	LRRC7	1
347365	ITIH6	2
8573	CASK	1
53616	ADAM22	1
9263	STK17A	3
5916	RARG	2
3069	HDLBP	2
11116	FGFR1OP	3
10320	IKZF1	2
3209	HOXA13	2
83481	EPPK1	1
390502	SERPINA2	2
5754	PTK7	1
6598	SMARCB1	4
9891	NUAK1	5
3694	ITGB6	2
3066	HDAC2	3
55781	RIOK2	3
8749	ADAM18	2
55534	MAML3	3
341676	NEK5	2
1545	CYP1B1	3
140469	MYO3B	1
943	TNFRSF8	3
577	ADGRB3	1
4283	CXCL9	3
10178	TENM1	1
9070	ASH2L	3
5533	PPP3CC	3
9411	ARHGAP29	2
8558	CDK10	3
3604	TNFRSF9	3
8295	TRRAP	2
2977	GUCY1A2	5
10438	C1D	5
7373	COL14A1	5
7158	TP53BP1	1
145264	SERPINA12	3
10295	BCKDK	4
2033	EP300	3
6927	HNF1A	2
54567	DLL4	1
8784	TNFRSF18	3
4001	LMNB1	6
9578	CDC42BPB	3
55728	N4BP2	2
3227	HOXC11	3
1453	CSNK1D	3
6390	SDHB	3
440279	UNC13C	1
2115	ETV1	1
5743	PTGS2	3
10272	FSTL3	3
342977	NANOS3	1
256646	NUTM1	1
23012	STK38L	3
57787	MARK4	6
6418	SET	3
4478	MSN	2
3927	LASP1	6
1586	CYP17A1	2
8396	PIP4K2B	6
2242	FES	2
3091	HIF1A	3
80351	TNKS2	2
6091	ROBO1	3
2260	FGFR1	6
5330	PLCB2	4
10188	TNK2	2
2736	GLI2	2
6198	RPS6KB1	2
83990	BRIP1	8
3303	HSPA1A	3
6928	HNF1B	1
27324	TOX3	6
207	AKT1	2
5898	RALA	3
4982	TNFRSF11B	3
23405	DICER1	2
1277	COL1A1	3
94103	ORMDL3	2
8395	PIP5K1B	4
993	CDC25A	2
54899	PXK	3
23191	CYFIP1	6
4294	MAP3K10	1
9131	AIFM1	3
57510	XPO5	2
1973	EIF4A1	3
1909	EDNRA	2
7166	TPH1	4
9472	AKAP6	2
3685	ITGAV	3
80243	PREX2	1
139285	AMER1	2
83903	HASPIN	4
575	ADGRB1	3
6792	CDKL5	2
1123	CHN1	1
1496	CTNNA2	2
7010	TEK	2
5450	POU2AF1	5
898	CCNE1	5
2050	EPHB4	1
2272	FHIT	1
10413	YAP1	3
2201	FBN2	1
9361	LONP1	3
57523	NYNRIN	2
83694	RPS6KL1	3
2868	GRK4	1
5336	PLCG2	2
10018	BCL2L11	1
28514	DLL1	3
27347	STK39	2
58508	KMT2C	4
7157	TP53	1
27086	FOXP1	5
4602	MYB	2
79058	ASPSCR1	2
6794	STK11	6
7869	SEMA3B	1
4292	MLH1	2
2263	FGFR2	2
9639	ARHGEF10	5
7249	TSC2	4
8874	ARHGEF7	6
1555	CYP2B6	8
1102	RCBTB2	3
23043	TNIK	2
5164	PDK2	3
5600	MAPK11	2
8893	EIF2B5	3
4921	DDR2	5
8660	IRS2	3
5077	PAX3	2
65125	WNK1	3
136332	LRGUK	2
50945	TBX22	5
30012	TLX3	3
5871	MAP4K2	4
80205	CHD9	5
23365	ARHGEF12	3
84181	CHD6	2
57578	UNC79	3
8997	KALRN	2
23269	MGA	2
7994	KAT6A	2
3643	INSR	2
54658	UGT1A1	1
10733	PLK4	1
835	CASP2	2
5727	PTCH1	1
51366	UBR5	2
3426	CFI	5
3417	IDH1	3
5297	PI4KA	2
3702	ITK	2
3239	HOXD13	5
5290	PIK3CA	7
3720	JARID2	4
5034	P4HB	4
1000	CDH2	3
2318	FLNC	2
10565	ARFGEF1	1
64919	BCL11B	1
675	BRCA2	1
607	BCL9	2
8445	DYRK2	5
640	BLK	5
64333	ARHGAP9	3
91	ACVR1B	5
5789	PTPRD	1
10461	MERTK	6
5753	PTK6	6
7297	TYK2	5
4684	NCAM1	2
6885	MAP3K7	3
894	CCND2	1
5462	POU5F1B	1
29951	PDZRN4	1
51265	CDKL3	3
51701	NLK	2
5156	PDGFRA	1
93627	TBCK	4
137872	ADHFE1	3
6872	TAF1	1
4790	NFKB1	3
84879	MFSD2A	1
1769	DNAH8	2
988	CDC5L	2
3315	HSPB1	5
23532	PRAME	1
4863	NPAT	5
5598	MAPK7	2
339345	NANOS2	2
120892	LRRK2	3
65268	WNK2	6
57507	ZNF608	2
7468	NSD2	1
8029	CUBN	2
23118	TAB2	3
8626	TP63	2
9113	LATS1	2
460	ASTN1	2
8178	ELL	2
7849	PAX8	5
9451	EIF2AK3	2
1977	EIF4E	3
51555	PEX5L	1
8491	MAP4K3	2
3654	IRAK1	3
23049	SMG1	2
8312	AXIN1	2
5728	PTEN	1
57521	RPTOR	1
140609	NEK7	3
1869	E2F1	2
115701	ALPK2	5
4004	LMO1	3
284086	NEK8	2
1613	DAPK3	3
2188	FANCF	3
658	BMPR1B	3
1676	DFFA	3
8301	PICALM	2
3899	AFF3	2
4055	LTBR	2
91807	MYLK3	2
7059	THBS3	2
8648	NCOA1	3
79012	CAMKV	1
9372	ZFYVE9	3
54861	SNRK	3
2046	EPHA8	5
7150	TOP1	2
8821	INPP4B	2
84930	MASTL	1
3207	HOXA11	3
23305	ACSL6	3
10595	ERN2	2
2317	FLNB	3
8031	NCOA4	2
100124696	TEC	2
7094	TLN1	2
1281	COL3A1	1
9659	PDE4DIP	5
2185	PTK2B	5
4628	MYH10	3
5170	PDPK1	5
7227	TRPS1	5
6778	STAT6	5
3516	RBPJ	2
6777	STAT5B	2
3552	IL1A	2
5932	RBBP8	2
330	BIRC3	3
1455	CSNK1G2	2
23512	SUZ12	6
11076	TPPP	2
7046	TGFBR1	5
7913	DEK	6
2122	MECOM	3
3662	IRF4	2
51167	CYB5R4	5
5087	PBX1	2
2903	GRIN2A	4
4217	MAP3K5	2
7113	TMPRSS2	4
7069	THRSP	1
7403	KDM6A	3
4638	MYLK	5
5586	PKN2	2
4205	MEF2A	3
7040	TGFB1	3
30849	PIK3R4	2
3488	IGFBP5	5
79728	PALB2	2
4915	NTRK2	2
4299	AFF1	2
84446	BRSK1	1
156	GRK2	6
57697	FANCM	2
9625	AATK	5
63893	UBE2O	2
5288	PIK3C2G	2
2044	EPHA5	3
3679	ITGA7	3
81788	NUAK2	5
3265	HRAS	3
2178	FANCE	4
1499	CTNNB1	4
5602	MAPK10	10
2892	GRIA3	3
5624	PROC	3

Gene in drug-gene network: Network Plot

Models in Triptolide

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.