NFKB1


Summary: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
nuclear factor kappa B subunit 1MIM:164011Ensembl:ENSG00000109320HGNC:HGNC:7794PA2484q24

GO terms in NFKB1


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0000976transcription regulatory region sequence-specific DNA binding
MFIDAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFIDAGO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0001205transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
MFIDAGO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIDAGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIDAGO:0008134transcription factor binding
MFIPIGO:0042802identical protein binding
MFIEAGO:0042803protein homodimerization activity
MFIPIGO:0042805actinin binding
MFIDAGO:0044212transcription regulatory region DNA binding
MFIDAGO:0046982protein heterodimerization activity
BPICGO:0000122negative regulation of transcription by RNA polymerase II
BPIGIGO:0000122negative regulation of transcription by RNA polymerase II
BPIMPGO:0000122negative regulation of transcription by RNA polymerase II
BPTASGO:0002223stimulatory C-type lectin receptor signaling pathway
BPTASGO:0006366transcription by RNA polymerase II
BPIEAGO:0006915apoptotic process
BPTASGO:0006954inflammatory response
BPIDAGO:0010629negative regulation of gene expression
BPICGO:0010744positive regulation of macrophage derived foam cell differentiation
BPICGO:0010884positive regulation of lipid storage
BPIDAGO:0010956negative regulation of calcidiol 1-monooxygenase activity
BPICGO:0010957negative regulation of vitamin D biosynthetic process
BPTASGO:0031293membrane protein intracellular domain proteolysis
BPICGO:0032269negative regulation of cellular protein metabolic process
BPICGO:0032375negative regulation of cholesterol transport
BPTASGO:0032481positive regulation of type I interferon production
BPIEAGO:0035994response to muscle stretch
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPTASGO:0043066negative regulation of apoptotic process
BPTASGO:0043312neutrophil degranulation
BPIEAGO:0045083negative regulation of interleukin-12 biosynthetic process
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPNASGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0050728negative regulation of inflammatory response
BPTASGO:0050852T cell receptor signaling pathway
BPTASGO:0051092positive regulation of NF-kappaB transcription factor activity
BPTASGO:0051403stress-activated MAPK cascade
BPTASGO:0070498interleukin-1-mediated signaling pathway
BPIMPGO:0071222cellular response to lipopolysaccharide
BPIEPGO:0071260cellular response to mechanical stimulus
BPIMPGO:0071316cellular response to nicotine
BPIEPGO:0071347cellular response to interleukin-1
BPIMPGO:0071354cellular response to interleukin-6
BPIEAGO:0071356cellular response to tumor necrosis factor
BPIEAGO:0071359cellular response to dsRNA
BPIMPGO:0090263positive regulation of canonical Wnt signaling pathway
BPIDAGO:1900127positive regulation of hyaluronan biosynthetic process
BPIMPGO:1904385cellular response to angiotensin
BPIMPGO:2000630positive regulation of miRNA metabolic process
CCTASGO:0005576extracellular region
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005739mitochondrion
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCTASGO:0033256I-kappaB/NF-kappaB complex
CCTASGO:0034774secretory granule lumen
CCTASGO:0035580specific granule lumen

Gene expression in normal tissue: NFKB1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NFKB1


DatabasePathway IDPathway Des.
biocartanfkbpathwaynf-kb signaling pathway
reactomeR-HSA-1168372Downstream signaling events of B Cell Receptor (BCR)
reactomeR-HSA-1169091Activation of NF-kappaB in B cells
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1606322ZBP1(DAI) mediated induction of type I IFNs
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/beta
reactomeR-HSA-1810476RIP-mediated NFkB activation via ZBP1
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-1834949Cytosolic sensors of pathogen-associated DNA
reactomeR-HSA-193639p75NTR signals via NF-kB
reactomeR-HSA-193692Regulated proteolysis of p75NTR
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202424Downstream TCR signaling
reactomeR-HSA-209560NF-kB is activated and signals survival
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-2871837FCERI mediated NF-kB activation
reactomeR-HSA-3134963DEx/H-box helicases activate type I IFN and inflammatory cytokines production
reactomeR-HSA-3214841PKMTs methylate histone lysines
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-445989TAK1 activates NFkB by phosphorylation and activation of IKKs complex
reactomeR-HSA-446652Interleukin-1 family signaling
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-448706Interleukin-1 processing
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-5260271Diseases of Immune System
reactomeR-HSA-5602358Diseases associated with the TLR signaling cascade
reactomeR-HSA-5603029IkBA variant leads to EDA-ID
reactomeR-HSA-5607764CLEC7A (Dectin-1) signaling
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-5621575CD209 (DC-SIGN) signaling
reactomeR-HSA-5660668CLEC7A/inflammasome pathway
reactomeR-HSA-5684264MAP3K8 (TPL2)-dependent MAPK1/3 activation
reactomeR-HSA-622312Inflammasomes
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-844456The NLRP3 inflammasome
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-9020702Interleukin-1 signaling
reactomeR-HSA-933542TRAF6 mediated NF-kB activation
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane
reactomeR-HSA-983705Signaling by the B Cell Receptor (BCR)
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
kegghsa04623Cytosolic DNA-sensing pathway - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05030Cocaine addiction - Homo sapiens (human)
kegghsa05120Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
kegghsa05131Shigellosis - Homo sapiens (human)
kegghsa05132Salmonella infection - Homo sapiens (human)
kegghsa05133Pertussis - Homo sapiens (human)
kegghsa05134Legionellosis - Homo sapiens (human)
kegghsa05140Leishmaniasis - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05168Herpes simplex infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05321Inflammatory bowel disease (IBD) - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
netpathPathway_BDNFBDNF
netpathPathway_CRHCRH
netpathPathway_EGFR1EGFR1
netpathPathway_Fibroblast__growth__factor-1Fibroblast growth factor-1
netpathPathway_GastrinGastrin
netpathPathway_IL1IL1
netpathPathway_IL2IL2
netpathPathway_IL3IL3
netpathPathway_IL4IL4
netpathPathway_IL5IL5
netpathPathway_IL6IL6
netpathPathway_NotchNotch
netpathPathway_Oncostatin_MOncostatin_M
netpathPathway_ProlactinProlactin
netpathPathway_RAGERAGE
netpathPathway_RANKLRANKL
netpathPathway_TCRTCR
netpathPathway_TNFalphaTNFalpha
netpathPathway_TSLPTSLP
netpathPathway_TWEAKTWEAK
smpdbSMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdbSMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
wikipathwaysWP1434Osteopontin Signaling
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP15Selenium Micronutrient Network
wikipathwaysWP1533Vitamin B12 Metabolism
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP1559TFs Regulate miRNAs related to cardiac hypertrophy
wikipathwaysWP176Folate Metabolism
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP195IL-1 signaling pathway
wikipathwaysWP2018RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2036TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP2064Neural Crest Differentiation
wikipathwaysWP2112IL17 signaling pathway
wikipathwaysWP2203Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2435Quercetin and Nf-kB- AP-1 Induced Cell Apoptosis
wikipathwaysWP254Apoptosis
wikipathwaysWP2583T-Cell Receptor and Co-stimulatory Signaling
wikipathwaysWP2586Aryl Hydrocarbon Receptor
wikipathwaysWP2593JAK-STAT
wikipathwaysWP262EBV LMP1 signaling
wikipathwaysWP2795Cardiac Hypertrophic Response
wikipathwaysWP28Selenium Metabolism and Selenoproteins
wikipathwaysWP2804Hair Follicle Development- Induction (Part 1 of 3)
wikipathwaysWP2864Apoptosis-related network due to altered Notch3 in ovarian cancer
wikipathwaysWP2865IL1 and megakaryocytes in obesity
wikipathwaysWP289Myometrial Relaxation and Contraction Pathways
wikipathwaysWP3298Melatonin metabolism and effects
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP3414Initiation of transcription and translation elongation at the HIV-1 LTR
wikipathwaysWP3617Photodynamic therapy-induced NF-kB survival signaling
wikipathwaysWP3630NAD metabolism, sirtuins and aging
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP3646Hepatitis C and Hepatocellular Carcinoma
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP384Apoptosis Modulation by HSP70
wikipathwaysWP3849MAPK and NFkB Signalling Pathways Inhibited by Yersinia YopJ
wikipathwaysWP3850Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling
wikipathwaysWP3851TLR4 Signaling and Tolerance
wikipathwaysWP3858Toll-like Receptor Signaling
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP3865RIG-I-like Receptor Signaling
wikipathwaysWP3877Simplified Depiction of MYD88 Distinct Input-Output Pathway
wikipathwaysWP3878ATM Signaling Network in Development and Disease
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3890Nanomaterial induced inflammasome activation
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3941Oxidative Damage
wikipathwaysWP395IL-4 Signaling Pathway
wikipathwaysWP3980Protein alkylation leading to liver fibrosis
wikipathwaysWP3981miRNA regulation of prostate cancer signaling pathways
wikipathwaysWP3995Prion disease pathway
wikipathwaysWP4008NO-cGMP-PKG mediated Neuroprotection
wikipathwaysWP408Oxidative Stress
wikipathwaysWP4136Fibrin Complement Receptor 3 Signaling Pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4180Ebola Virus Pathway on Host
wikipathwaysWP4217Ebola Virus Pathway on Host
wikipathwaysWP4223Ras Signaling
wikipathwaysWP560TGF-beta Receptor Signaling
wikipathwaysWP61Notch Signaling Pathway
wikipathwaysWP69T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
wikipathwaysWP710DNA Damage Response (only ATM dependent)
wikipathwaysWP712Estrogen signaling pathway
wikipathwaysWP75Toll-like Receptor Signaling Pathway
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkbPA165292163Doxorubicin Pathway (Cancer Cell), Pharmacodynamics
pharmgkbPA165985892Tacrolimus/Cyclosporine Pathway, Pharmacodynamics
pidamb2_neutrophils_pathwayamb2 Integrin signaling
pidangiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
pidavb3_opn_pathwayOsteopontin-mediated events
pidbcr_5pathwayBCR signaling pathway
pidcd40_pathwayCD40/CD40L signaling
pidceramide_pathwayCeramide signaling pathway
pidepopathwayEPO signaling pathway
pidfcer1pathwayFc-epsilon receptor I signaling in mast cells
pidhdac_classi_pathwaySignaling events mediated by HDAC Class I
pidhivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
pidil12_2pathwayIL12-mediated signaling events
pidil1pathwayIL1-mediated signaling events
pidil23pathwayIL23-mediated signaling events
pidil2_pi3kpathwayIL2 signaling events mediated by PI3K
pidlysophospholipid_pathwayLPA receptor mediated events
pidnfkappabalternativepathwayAlternative NF-kappaB pathway
pidnfkappabatypicalpathwayAtypical NF-kappaB pathway
pidnfkappabcanonicalpathwayCanonical NF-kappaB pathway
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pidtelomerasepathwayRegulation of Telomerase
pidtnfpathwayTNF receptor signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD192CIL563
iGMDRD434BMS-5369243
iGMDRD105Triptolide3
iGMDRD289Parthenolide3
iGMDRD263AACOCF33
iGMDRD246NPC269
iGMDRD147Prima-13
iGMDRD872BRD71373
iGMDRD286Nsc 6328393
iGMDRD871BRD63683
iGMDRD269Purmorphamine1
iGMDRD329Merck603
iGMDRD662JQ-13
iGMDRD424Tamatinib6
iGMDRD701NVP-AUY9223
iGMDRD84Lovastatin acid3
iGMDRD148Pifithrin-mu1
iGMDRD512nutlin 33
iGMDRD945ML2143
iGMDRD132(-)-gallocatechin-3-O-gallate4
iGMDRD30917AAG1
iGMDRD138PX 123
iGMDRD474Avrainvillamide5
iGMDRD513BML-2591
iGMDRD255SB2250023
iGMDRD64Parbendazole3
iGMDRD690PRIMA-1MET3
iGMDRD451Serdemetan3
iGMDRD444Tivantinib2
iGMDRD23Gossypol2
iGMDRD188Piperlongumine3
iGMDRD398Sepantronium3
iGMDRD506Fedratinib3
iGMDRD427ABT7373
iGMDRD144NSC953973
iGMDRD781Sirolimus3
iGMDRD420Leucascandrolide A3
iGMDRD889Compound 7d-cis1
iGMDRD280CYTOCHALASIN B4
iGMDRD394BX-7953
iGMDRD466Chaetocin3
iGMDRD193Fqi13

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NFKB1

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