NFKB1

Summary: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namenuclear factor kappa B subunit 1
OMIM IDMIM:164011
Ensembl IDEnsembl:ENSG00000109320
HGNC IDHGNC:HGNC:7794
PHARMGKB IDPA248
Map Location4q24

GO terms in NFKB1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000976 transcription regulatory region sequence-specific DNA binding
MF IDA GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
MF IDA GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
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Gene expression in normal tissue: NFKB1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 101LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 11BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 13BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 2

Gene-drug pathway distribution

undefined32Protein stability and degradation2Apoptosis regulation1Other, kinases1Longevity regulating pathway1Biosynthesis of secondary metabolites1p53 pathway1Chromatin histone acetylation1Chromatin other1RTK signaling1

Pathways in NFKB1


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Database
Pathway ID
Pathway Des.
biocarta nfkbpathway nf-kb signaling pathway
reactome R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR)
reactome R-HSA-1169091 Activation of NF-kappaB in B cells
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-1280218 Adaptive Immune System
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD192 CIL56 3
iGMDRD434 BMS-536924 3
iGMDRD105 Triptolide 3
iGMDRD289 Parthenolide 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NFKB1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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