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iGMDRD434

Canonical SMILES: CC1=CC(=CC2=C1NC(=C3C(=CC=NC3=O)NCC(C4=CC(=CC=C4)Cl)O)N2)N5CCOCC5

InChI: InChI=1S/C25H26ClN5O3/c1-15-11-18(31-7-9-34-10-8-31)13-20-23(15)30-24(29-20)22-19(5-6-27-25(22)33)28-14-21(32)16-3-2-4-17(26)12-16/h2-6,11-13,21,28-30,32H,7-10,14H2,1H3/t21-/m1/s1

InChI Key: UGQMURPIMYALPH-OAQYLSRUSA-N

Standard Name	CHEMBL	Pubchem CID	Drug Status	Drug Type
BMS-536924	CHEMBL401930	68925400	Alone	Small Molecule

Drug Targets:

IGF1R INSR

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
64901	RANBP17	3
8999	CDKL2	1
6664	SOX11	3
10460	TACC3	3
81037	CLPTM1L	2
5027	P2RX7	5
997	CDC34	3
7837	PXDN	6
79054	TRPM8	4
1464	CSPG4	2
3490	IGFBP7	1
23085	ERC1	7
8444	DYRK3	1
10987	COPS5	1
9261	MAPKAPK2	2
21	ABCA3	5
132	ADK	2
4751	NEK2	4
6774	STAT3	2
5933	RBL1	3
6195	RPS6KA1	1
4926	NUMA1	5
11183	MAP4K5	2
4291	MLF1	2
79947	DHDDS	3
5546	PRCC	2
2956	MSH6	5
2200	FBN1	3
26286	ARFGAP3	1
55872	PBK	3
57679	ALS2	1
220064	LTO1	1
150465	TTL	3
3708	ITPR1	3
1588	CYP19A1	2
1969	EPHA2	3
9149	DYRK1B	3
7272	TTK	2
3845	KRAS	12
1138	CHRNA5	8
4750	NEK1	2
5295	PIK3R1	2
23097	CDK19	3
6351	CCL4	5
701	BUB1B	2
8573	CASK	3
51231	VRK3	3
11193	WBP4	2
51129	ANGPTL4	3
5593	PRKG2	2
53616	ADAM22	2
3431	SP110	3
6938	TCF12	3
2475	MTOR	2
9263	STK17A	2
6597	SMARCA4	4
81035	COLEC12	3
10395	DLC1	1
5133	PDCD1	2
10320	IKZF1	2
4094	MAF	3
7444	VRK2	3
6657	SOX2	2
390502	SERPINA2	1
53944	CSNK1G1	4
5754	PTK7	2
56776	FMN2	3
5079	PAX5	2
4172	MCM3	1
10863	ADAM28	5
4170	MCL1	3
1607	DGKB	4
1272	CNTN1	3
9641	IKBKE	3
10142	AKAP9	1
22853	LMTK2	2
7098	TLR3	6
6732	SRPK1	5
27	ABL2	2
8749	ADAM18	2
2241	FER	6
8737	RIPK1	3
22821	RASA3	2
6318	SERPINB4	1
9816	URB2	7
4092	SMAD7	2
84299	MIEN1	5
4149	MAX	2
604	BCL6	1
114908	TMEM123	1
7048	TGFBR2	2
54822	TRPM7	3
51199	NIN	3
577	ADGRB3	5
80122	MAP3K19	2
28231	SLCO4A1	2
114783	LMTK3	2
112858	TP53RK	2
11329	STK38	3
26039	SS18L1	2
10454	TAB1	3
127933	UHMK1	3
5788	PTPRC	4
2313	FLI1	7
56164	STK31	3
4283	CXCL9	3
10013	HDAC6	1
2984	GUCY2C	3
11200	CHEK2	2
7133	TNFRSF1B	2
10178	TENM1	3
51755	CDK12	1
5533	PPP3CC	4
3055	HCK	3
5074	PAWR	4
29998	BICRA	5
8295	TRRAP	3
2977	GUCY1A2	7
10438	C1D	2
11122	PTPRT	1
23617	TSSK2	1
9024	BRSK2	2
5396	PRRX1	4
5465	PPARA	3
5314	PKHD1	4
5605	MAP2K2	3
51512	GTSE1	2
139378	ADGRG4	5
7158	TP53BP1	2
89910	UBE3B	4
6927	HNF1A	2
54567	DLL4	5
641	BLM	2
5914	RARA	5
7307	U2AF1	2
1454	CSNK1E	3
55728	N4BP2	1
25865	PRKD2	3
25925	ZNF521	3
7852	CXCR4	3
54477	PLEKHA5	2
57670	KIAA1549	2
837	CASP4	3
440279	UNC13C	2
340156	MYLK4	2
2115	ETV1	3
4301	AFDN	1
5081	PAX7	3
55819	RNF130	3
5743	PTGS2	4
11011	TLK2	3
342667	STAC2	5
57396	CLK4	2
256646	NUTM1	2
2118	ETV4	3
7025	NR2F1	1
1880	GPR183	2
122011	CSNK1A1L	2
646643	SBK2	3
169436	STKLD1	2
4478	MSN	5
1586	CYP17A1	2
3714	JAG2	3
32	ACACB	2
8852	AKAP4	3
3556	IL1RAP	1
329	BIRC2	1
4300	MLLT3	2
22806	IKZF3	8
2242	FES	5
4005	LMO2	2
3645	INSRR	2
22984	PDCD11	2
6041	RNASEL	3
80351	TNKS2	2
6091	ROBO1	4
5330	PLCB2	1
23255	MTCL1	2
80129	CCDC170	3
5984	RFC4	3
4216	MAP3K4	2
6198	RPS6KB1	3
597	BCL2A1	6
2908	NR3C1	3
51804	SIX4	3
3688	ITGB1	6
9098	USP6	3
7088	TLE1	6
284217	LAMA1	6
7424	VEGFC	1
4982	TNFRSF11B	2
23405	DICER1	2
238	ALK	1
399979	SNX19	3
1277	COL1A1	3
375449	MAST4	1
4752	NEK3	3
22858	ICK	2
2064	ERBB2	3
94103	ORMDL3	5
983	CDK1	3
85443	DCLK3	1
6850	SYK	7
57476	GRAMD1B	2
83983	TSSK6	2
65217	PCDH15	3
8395	PIP5K1B	2
6663	SOX10	4
993	CDC25A	3
55361	PI4K2A	2
7486	WRN	7
1456	CSNK1G3	3
5580	PRKCD	3
4140	MARK3	1
5127	CDK16	2
9759	HDAC4	2
92	ACVR2A	3
10400	PEMT	2
57510	XPO5	1
8215	DVL1P1	4
50488	MINK1	5
8859	STK19	3
80312	TET1	6
6464	SHC1	6
7166	TPH1	3
6037	RNASE3	2
6098	ROS1	1
54437	SEMA5B	1
8515	ITGA10	3
124923	SGK494	2
2778	GNAS	4
9590	AKAP12	1
3685	ITGAV	3
3667	IRS1	3
80243	PREX2	3
472	ATM	6
139285	AMER1	2
3397	ID1	2
2734	GLG1	3
84433	CARD11	6
9096	TBX18	2
8038	ADAM12	1
1123	CHN1	3
7010	TEK	9
7533	YWHAH	2
23152	CIC	4
8798	DYRK4	2
5863	RGL2	4
51517	NCKIPSD	3
9319	TRIP13	6
1029	CDKN2A	3
5108	PCM1	1
23048	FNBP1	2
57523	NYNRIN	2
5336	PLCG2	3
11143	KAT7	5
28514	DLL1	2
11197	WIF1	2
8743	TNFSF10	2
55190	NUDT11	1
3932	LCK	1
58508	KMT2C	2
7157	TP53	3
2099	ESR1	3
6092	ROBO2	3
7704	ZBTB16	3
4088	SMAD3	3
3170	FOXA2	1
4855	NOTCH4	2
2322	FLT3	2
25836	NIPBL	2
57410	SCYL1	3
3791	KDR	4
10114	HIPK3	3
7170	TPM3	2
6772	STAT1	2
93210	PGAP3	5
3000	GUCY2D	2
2263	FGFR2	4
106480993	RN7SL263P	3
8408	ULK1	2
5585	PKN1	3
9639	ARHGEF10	1
7249	TSC2	5
11213	IRAK3	2
8833	GMPS	3
4869	NPM1	4
344387	CDKL4	3
863	CBFA2T3	4
8874	ARHGEF7	3
1102	RCBTB2	1
7422	VEGFA	1
8893	EIF2B5	3
7038	TG	3
3572	IL6ST	3
6197	RPS6KA3	2
65125	WNK1	2
57591	MRTFA	3
7495	XBP1P1	1
4436	MSH2	1
1656	DDX6	2
7175	TPR	3
5871	MAP4K2	5
9401	RECQL4	3
54106	TLR9	3
80205	CHD9	2
84181	CHD6	3
57578	UNC79	1
4026	LPP	2
8997	KALRN	2
2071	ERCC3	3
3643	INSR	3
4904	YBX1	1
5888	RAD51	3
57551	TAOK1	2
6280	S100A9	2
2175	FANCA	2
5371	PML	5
23469	PHF3	1
4089	SMAD4	1
170692	ADAMTS18	6
672	BRCA1	7
2060	EPS15	3
1616	DAXX	4
11168	PSIP1	3
10948	STARD3	5
1848	DUSP6	5
256536	TCERG1L	3
139760	GPR119	2
78989	COLEC11	1
51366	UBR5	3
3426	CFI	1
5297	PI4KA	3
5069	PAPPA	6
501	ALDH7A1	2
3558	IL2	3
10535	RNASEH2A	2
64840	PORCN	2
30827	CXXC1	3
340533	NEXMIF	2
5578	PRKCA	3
4214	MAP3K1	2
8731	RNMT	1
9972	NUP153	6
5290	PIK3CA	2
92335	STRADA	3
3720	JARID2	4
1514	CTSL	4
26524	LATS2	1
6391	SDHC	3
2318	FLNC	3
64919	BCL11B	2
5530	PPP3CA	3
675	BRCA2	8
26166	RGS22	1
607	BCL9	2
54894	RNF43	2
7075	TIE1	2
744	MPPED2	1
1956	EGFR	1
157680	VPS13B	3
841	CASP8	5
2735	GLI1	5
3065	HDAC1	3
4609	MYC	2
64333	ARHGAP9	5
11064	CNTRL	2
64750	SMURF2	2
91	ACVR1B	2
3308	HSPA4	3
842	CASP9	3
8021	NUP214	2
1459	CSNK2A2	2
10461	MERTK	3
8795	TNFRSF10B	2
26278	SACS	1
894	CCND2	2
896	CCND3	1
1440	CSF3	5
29951	PDZRN4	2
6776	STAT5A	2
6446	SGK1	2
5592	PRKG1	6
1594	CYP27B1	3
2189	FANCG	4
5156	PDGFRA	2
7443	VRK1	3
204851	HIPK1	3
3635	INPP5D	3
1653	DDX1	3
5187	PER1	1
7917	BAG6	4
375056	MIA3	6
10971	YWHAQ	3
10000	AKT3	3
91754	NEK9	2
93627	TBCK	8
27330	RPS6KA6	1
7132	TNFRSF1A	3
7189	TRAF6	2
3949	LDLR	2
56924	PAK6	2
203102	ADAM32	1
673	BRAF	2
7153	TOP2A	5
4790	NFKB1	3
6011	GRK1	5
1769	DNAH8	7
22976	PAXIP1	1
4863	NPAT	3
780	DDR1	3
57538	ALPK3	4
8924	HERC2	2
120892	LRRK2	7
998	CDC42	6
79184	BRCC3	2
146057	TTBK2	2
57507	ZNF608	4
84441	MAML2	6
5205	ATP8B1	3
7468	NSD2	2
8029	CUBN	4
23118	TAB2	1
8626	TP63	3
5294	PIK3CG	2
5979	RET	2
9321	TRIP11	3
9843	HEPH	6
8491	MAP4K3	2
157	GRK3	3
3229	HOXC13	3
23742	NPAP1	2
23049	SMG1	5
10010	TANK	5
8312	AXIN1	3
1806	DPYD	1
55521	TRIM36	2
5728	PTEN	8
57521	RPTOR	3
51592	TRIM33	1
2316	FLNA	3
5595	MAPK3	2
140609	NEK7	2
7155	TOP2B	3
80124	VCPIP1	3
4914	NTRK1	4
22883	CLSTN1	2
667	DST	4
23281	MTUS2	3
4004	LMO1	3
284086	NEK8	4
1613	DAPK3	2
5305	PIP4K2A	3
4317	MMP8	5
2188	FANCF	3
6146	RPL22	1
9135	RABEP1	2
57139	RGL3	3
10962	MLLT11	1
1950	EGF	6
658	BMPR1B	3
8301	PICALM	1
23090	ZNF423	3
1018	CDK3	1
8522	GAS7	2
91807	MYLK3	7
171023	ASXL1	1
6789	STK4	3
348378	SHISAL2A	3
23332	CLASP1	6
7059	THBS3	3
23389	MED13L	2
203447	NRK	3
6787	NEK4	2
54904	NSD3	2
23411	SIRT1	6
53904	MYO3A	2
3161	HMMR	2
9372	ZFYVE9	1
55561	CDC42BPG	6
10249	GLYAT	4
1027	CDKN1B	3
128869	PIGU	2
10243	GPHN	3
115650	TNFRSF13C	3
9943	OXSR1	3
286151	FBXO43	4
1662	DDX10	2
344905	ATP13A5	4
29994	BAZ2B	1
4297	KMT2A	4
7385	UQCRC2	1
5291	PIK3CB	2
3611	ILK	1
558	AXL	6
126792	B3GALT6	2
9748	SLK	6
4619	MYH1	4
332	BIRC5	1
2932	GSK3B	3
2869	GRK5	1
5581	PRKCE	2
4774	NFIA	2
64764	CREB3L2	2
317	APAF1	3
2690	GHR	4
2317	FLNB	4
10111	RAD50	3
9223	MAGI1	5
860	RUNX2	3
171389	NLRP6	2
53353	LRP1B	4
7094	TLN1	2
3181	HNRNPA2B1	5
1281	COL3A1	2
2185	PTK2B	3
7293	TNFRSF4	1
3557	IL1RN	3
5335	PLCG1	4
2130	EWSR1	3
2194	FASN	5
4628	MYH10	2
598	BCL2L1	4
5583	PRKCH	3
5170	PDPK1	6
2321	FLT1	2
6196	RPS6KA2	3
3717	JAK2	1
22982	DIP2C	1
7099	TLR4	4
2157	F8	1
5506	PPP1R3A	3
1627	DBN1	1
79837	PIP4K2C	1
3709	ITPR2	5
57147	SCYL3	3
11040	PIM2	2
4221	MEN1	6
8899	PRPF4B	9
4067	LYN	2
65267	WNK3	4
3984	LIMK1	3
8428	STK24	2
4772	NFATC1	5
3516	RBPJ	3
3552	IL1A	1
5932	RBBP8	6
5915	RARB	3
7112	TMPO	3
4261	CIITA	6
3656	IRAK2	1
4330	MN1	6
84072	HORMAD1	3
23250	ATP11A	3
7046	TGFBR1	2
7913	DEK	2
3662	IRF4	3
5054	SERPINE1	1
2903	GRIN2A	6
5925	RB1	2
1515	CTSV	2
1026	CDKN1A	6
25	ABL1	3
8661	EIF3A	3
1576	CYP3A4	2
7403	KDM6A	1
1234	CCR5	2
2308	FOXO1	3
4615	MYD88	3
4302	MLLT6	5
4638	MYLK	2
5586	PKN2	3
57120	GOPC	1
3480	IGF1R	2
2011	MARK2	4
23092	ARHGAP26	3
51135	IRAK4	1
4915	NTRK2	2
2651	GCNT2	2
142	PARP1	3
2261	FGFR3	1
23072	HECW1	8
139604	MAGEB16	2
3237	HOXD11	3
2073	ERCC5	2
79577	CDC73	6
5567	PRKACB	6
8711	TNK1	2
581	BAX	3
4763	NF1	3
57697	FANCM	2
1612	DAPK1	4
138474	TAF1L	2
1994	ELAVL1	5
4613	MYCN	1
63893	UBE2O	3
1840	DTX1	3
4591	TRIM37	3
440270	GOLGA8B	4
5288	PIK3C2G	3
973	CD79A	3
94	ACVRL1	4
5287	PIK3C2B	2
4593	MUSK	3
10048	RANBP9	2
6943	TCF21	1
29110	TBK1	1
5885	RAD21	2
1499	CTNNB1	1
2444	FRK	2
27151	CPAMD8	2
3440	IFNA2	1
5602	MAPK10	2
2892	GRIA3	5
1436	CSF1R	3
2886	GRB7	11
1795	DOCK3	2
4486	MST1R	3
578	BAK1	3

Gene in drug-gene network: Network Plot

Models in BMS-536924

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DATATYPES

CLASSFICATION

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