RCBTB2
Summary: This gene encodes a protein containing two C-terminal BTB/POZ domains that is related to regulator of chromosome condensation (RCC). The encoded protein may act as a guanine nucleotide exchange factor. This gene is observed to be lost or underexpressed in prostate cancers. There is a pseudogene of this gene on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RCC1 and BTB domain containing protein 2 | MIM:603524 | Ensembl:ENSG00000136161 | HGNC:HGNC:1914 | PA26450 | 13q14.2 |
GO terms in RCBTB2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0001669 | acrosomal vesicle |
| MF | TAS | GO:0005087 | Ran guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: RCBTB2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RCBTB2
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD152 | 179324-69-7 | 4 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 1 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD484 | Pluripotin | 2 |
| iGMDRD126 | Tipifarnib | 8 |
| iGMDRD772 | BRD4770 | 1 |
| iGMDRD579 | PF750 | 1 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD213 | SMR000068650 | 1 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD271 | Brefeldin A | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RCBTB2
CLASSFICATION
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