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iGMDRD271

Canonical SMILES: CC1CCCC=CC2CC(CC2C(C=CC(=O)O1)O)O

InChI: InChI=1S/C16H24O4/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3/b6-4+,8-7+/t11-,12+,13-,14+,15+/m0/s1

InChI Key: KQNZDYYTLMIZCT-KQPMLPITSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Brefeldin A	CHEMBL19980	5287620	DB07348	Alone	Small Molecule

Drug Class:

Anti-Bacterial Agents Anti-Infective Agents Antiviral Agents Enzyme Inhibitors Lactones Macrocyclic Compounds Macrolides P-glycoprotein/ABCB1 Inhibitors Polycyclic Compounds Polyketides Protein Synthesis Inhibitors

Drug Targets:

CYTH2 (Q99418)ARF1 (P84077)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
331	XIAP	3
3696	ITGB8	3
64901	RANBP17	3
4854	NOTCH3	2
8999	CDKL2	2
8019	BRD3	2
7750	ZMYM2	2
29101	SSU72	4
2986	GUCY2F	2
2956	MSH6	1
150465	TTL	3
1588	CYP19A1	3
1520	CTSS	1
9706	ULK2	3
347365	ITIH6	3
2100	ESR2	3
137994	LETM2	1
3939	LDHA	3
79092	CARD14	1
3431	SP110	1
8780	RIOK3	3
11116	FGFR1OP	3
1786	DNMT1	2
23213	SULF1	3
341676	NEK5	2
6318	SERPINB4	2
80122	MAP3K19	3
114783	LMTK3	2
1813	DRD2	3
4881	NPR1	3
31	ACACA	1
2977	GUCY1A2	3
10438	C1D	2
5396	PRRX1	3
8030	CCDC6	1
83439	TCF7L1	2
4595	MUTYH	3
23522	KAT6B	3
342977	NANOS3	1
152137	CCDC50	2
11073	TOPBP1	3
8767	RIPK2	3
5613	PRKX	3
329	BIRC2	3
4300	MLLT3	1
8313	AXIN2	3
51343	FZR1	1
114548	NLRP3	2
9636	ISG15	3
6928	HNF1B	1
269	AMHR2	2
5898	RALA	3
7016	TESK1	3
6850	SYK	1
54899	PXK	2
1456	CSNK1G3	3
6416	MAP2K4	5
92	ACVR2A	2
1452	CSNK1A1	2
5286	PIK3C2A	3
6709	SPTAN1	3
8215	DVL1P1	3
3685	ITGAV	2
1496	CTNNA2	1
7533	YWHAH	2
51517	NCKIPSD	3
79442	LRRC2	3
23048	FNBP1	3
959	CD40LG	3
5834	PYGB	1
4602	MYB	2
6794	STK11	3
25836	NIPBL	2
1019	CDK4	3
85481	PSKH2	3
8874	ARHGEF7	2
1102	RCBTB2	2
7038	TG	4
369	ARAF	2
9965	FGF19	1
6197	RPS6KA3	1
57188	ADAMTSL3	6
50945	TBX22	3
84181	CHD6	4
4026	LPP	5
4089	SMAD4	1
256536	TCERG1L	6
546	ATRX	4
64840	PORCN	2
30827	CXXC1	6
3702	ITK	3
3239	HOXD13	3
50615	IL21R	2
5290	PIK3CA	1
1000	CDH2	3
4145	MATK	3
7043	TGFB3	3
1956	EGFR	3
841	CASP8	1
64333	ARHGAP9	6
8021	NUP214	2
5315	PKM	1
1326	MAP3K8	3
29951	PDZRN4	2
51265	CDKL3	3
5663	PSEN1	3
2189	FANCG	3
93627	TBCK	2
3949	LDLR	2
673	BRAF	4
4863	NPAT	2
57538	ALPK3	3
5598	MAPK7	5
7301	TYRO3	1
5205	ATP8B1	2
5979	RET	3
8491	MAP4K3	3
9509	ADAMTS2	1
23396	PIP5K1C	3
55521	TRIM36	2
140803	TRPM6	1
6770	STAR	2
5582	PRKCG	2
995	CDC25C	2
7465	WEE1	3
85415	RHPN2	3
5291	PIK3CB	2
7248	TSC1	2
3985	LIMK2	3
2869	GRK5	2
5923	RASGRF1	3
5562	PRKAA1	3
317	APAF1	2
2317	FLNB	5
10111	RAD50	2
860	RUNX2	3
55289	ACOXL	2
3181	HNRNPA2B1	3
5609	MAP2K7	2
9201	DCLK1	3
1385	CREB1	3
6196	RPS6KA2	3
57007	ACKR3	3
1627	DBN1	2
1030	CDKN2B	2
84254	CAMKK1	1
7112	TMPO	3
170685	NUDT10	3
2903	GRIN2A	1
5925	RB1	4
25	ABL1	2
862	RUNX1T1	2
4205	MEF2A	3
55959	SULF2	1
3488	IGFBP5	4
2651	GCNT2	2
142	PARP1	2
374	AREG	3
2261	FGFR3	2
3092	HIP1	2
156	GRK2	1
1840	DTX1	2
94	ACVRL1	1
23031	MAST3	2
3679	ITGA7	1
1608	DGKG	4
4193	MDM2	2
2178	FANCE	2
5885	RAD21	3
2444	FRK	2
1795	DOCK3	4
167359	NIM1K	2
5624	PROC	3
5970	RELA	5

Gene in drug-gene network: Network Plot

Models in Brefeldin A

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DATATYPES

CLASSFICATION

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