FGFR3
Summary: This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| fibroblast growth factor receptor 3 | MIM:134934 | Ensembl:ENSG00000068078 | HGNC:HGNC:3690 | PA28129 | 4p16.3 |
GO terms in FGFR3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IDA | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IMP | GO:0005007 | fibroblast growth factor-activated receptor activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | IDA | GO:0017134 | fibroblast growth factor binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0001501 | skeletal system development |
| BP | TAS | GO:0001958 | endochondral ossification |
| BP | TAS | GO:0002062 | chondrocyte differentiation |
| BP | TAS | GO:0003416 | endochondral bone growth |
| BP | IEA | GO:0007267 | cell-cell signaling |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IBA | GO:0008284 | positive regulation of cell proliferation |
| BP | IGI | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | IGI | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | TAS | GO:0008543 | fibroblast growth factor receptor signaling pathway |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IMP | GO:0010518 | positive regulation of phospholipase activity |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | ISS | GO:0030282 | bone mineralization |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | TAS | GO:0035988 | chondrocyte proliferation |
| BP | IEA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | IMP | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IMP | GO:0043410 | positive regulation of MAPK cascade |
| BP | IMP | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity |
| BP | TAS | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | ISS | GO:0048640 | negative regulation of developmental growth |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | ISS | GO:0060349 | bone morphogenesis |
| BP | TAS | GO:0060349 | bone morphogenesis |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | ISS | GO:0070977 | bone maturation |
| BP | IMP | GO:1902178 | fibroblast growth factor receptor apoptotic signaling pathway |
| CC | IEA | GO:0005576 | extracellular region |
| CC | IEA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | TAS | GO:0005925 | focal adhesion |
| CC | IEA | GO:0009986 | cell surface |
| CC | IDA | GO:0030133 | transport vesicle |
| CC | IBA | GO:0043235 | receptor complex |
Gene expression in normal tissue: FGFR3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FGFR3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | fgf_pathway | FGF signaling pathway |
| pid | syndecan_1_pathway | Syndecan-1-mediated signaling events |
| pid | syndecan_2_pathway | Syndecan-2-mediated signaling events |
| pid | syndecan_3_pathway | Syndecan-3-mediated signaling events |
| pharmgkb | PA165980050 | Vemurafenib Pathway, Pharmacodynamics |
| pharmgkb | PA165980050 | update your name in edit mode |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05219 | Bladder cancer - Homo sapiens (human) |
| kegg | hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP2828 | Bladder Cancer |
| wikipathways | WP3413 | NOTCH1 regulation of human endothelial cell calcification |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP474 | Endochondral Ossification |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| reactome | R-HSA-109704 | PI3K Cascade |
| reactome | R-HSA-112399 | IRS-mediated signalling |
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1839130 | Signaling by activated point mutants of FGFR3 |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-190239 | FGFR3 ligand binding and activation |
| reactome | R-HSA-190371 | FGFR3b ligand binding and activation |
| reactome | R-HSA-190372 | FGFR3c ligand binding and activation |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-2033514 | FGFR3 mutant receptor activation |
| reactome | R-HSA-2033515 | t(4;14) translocations of FGFR3 |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428928 | IRS-related events triggered by IGF1R |
| reactome | R-HSA-5654227 | Phospholipase C-mediated cascade; FGFR3 |
| reactome | R-HSA-5654704 | SHC-mediated cascade:FGFR3 |
| reactome | R-HSA-5654706 | FRS-mediated FGFR3 signaling |
| reactome | R-HSA-5654708 | Downstream signaling of activated FGFR3 |
| reactome | R-HSA-5654710 | PI-3K cascade:FGFR3 |
| reactome | R-HSA-5654732 | Negative regulation of FGFR3 signaling |
| reactome | R-HSA-5654741 | Signaling by FGFR3 |
| reactome | R-HSA-5655332 | Signaling by FGFR3 in disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-8853334 | Signaling by FGFR3 fusions in cancer |
| reactome | R-HSA-8853338 | Signaling by FGFR3 point mutants in cancer |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD255 | SB225002 | 6 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD277 | SU-5402 | 1 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD911 | FGFR inhibitor | 13 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD297 | Austocystin D | 5 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD498 | GW441756X | 1 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD300 | Tozasertib | 4 |
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD3 | PD-173074 | 1 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD652 | UNC0638 | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD499 | PDMP | 1 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 1 |
| iGMDRD351 | GW843682X | 5 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD190 | Nilotinib | 1 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD188 | Piperlongumine | 8 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD397 | Pazopanib | 1 |
| iGMDRD546 | BMS-754807 | 6 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD126 | Tipifarnib | 7 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD433 | Lexibulin | 5 |
| iGMDRD152 | 179324-69-7 | 4 |
| iGMDRD705 | Nakiterpiosin | 4 |
| iGMDRD674 | Dovitinib | 1 |
| iGMDRD103 | SN-38 | 6 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD48 | Dexamethasone | 2 |
| iGMDRD184 | IPA-3 | 1 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD314 | Tanespimycin | 4 |
| iGMDRD237 | ABT-751 | 4 |
| iGMDRD341 | Triacsin c | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FGFR3
CLASSFICATION
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