iGMDRD399
Standard Name | CHEMBL | Pubchem CID | DRUGBANK ID | Drug Status | Drug Type |
---|---|---|---|---|---|
Selumetinib | CHEMBL2105684 CHEMBL1614701 | 10127600 | DB11689 | Alone | Small Molecule |
Drug Pathways:
ERK MAPK signalingDrug-model tissue-cancer distribution: Bubble Plot
Drug-gene pathway enrichments
Drug-gene GO enrichments
Drug-Gene: Aster Plot
Gene ID | Gene Name | Model Num. |
---|---|---|
3294 | HSD17B2 | 1 |
331 | XIAP | 2 |
8618 | CADPS | 1 |
3696 | ITGB8 | 3 |
1147 | CHUK | 2 |
1105 | CHD1 | 1 |
4854 | NOTCH3 | 2 |
7514 | XPO1 | 1 |
8241 | RBM10 | 1 |
8999 | CDKL2 | 3 |
10903 | MTMR11 | 1 |
471 | ATIC | 3 |
55510 | DDX43 | 1 |
10641 | NPRL2 | 3 |
7128 | TNFAIP3 | 3 |
8444 | DYRK3 | 3 |
8476 | CDC42BPA | 3 |
11183 | MAP4K5 | 2 |
114801 | TMEM200A | 3 |
64061 | TSPYL2 | 1 |
5546 | PRCC | 5 |
2956 | MSH6 | 1 |
2200 | FBN1 | 3 |
79767 | ELMO3 | 1 |
54602 | NDFIP2 | 2 |
3708 | ITPR1 | 4 |
103 | ADAR | 1 |
1588 | CYP19A1 | 2 |
1520 | CTSS | 2 |
80237 | ELL3 | 1 |
9149 | DYRK1B | 3 |
7272 | TTK | 2 |
347365 | ITIH6 | 7 |
3845 | KRAS | 21 |
3757 | KCNH2 | 3 |
100289092 | ATP2A1-AS1 | 2 |
4750 | NEK1 | 2 |
5295 | PIK3R1 | 2 |
100505865 | LINC00920 | 2 |
8289 | ARID1A | 1 |
80070 | ADAMTS20 | 6 |
26511 | CHIC2 | 2 |
2335 | FN1 | 2 |
4928 | NUP98 | 3 |
5593 | PRKG2 | 3 |
53616 | ADAM22 | 2 |
57709 | SLC7A14 | 1 |
2475 | MTOR | 3 |
9475 | ROCK2 | 3 |
27094 | KCNMB3 | 1 |
83942 | TSSK1B | 2 |
6597 | SMARCA4 | 1 |
644353 | ZCCHC18 | 2 |
3326 | HSP90AB1 | 3 |
9869 | SETDB1 | 4 |
4036 | LRP2 | 3 |
7764 | ZNF217 | 3 |
353345 | GPR141 | 4 |
89866 | SEC16B | 1 |
5133 | PDCD1 | 2 |
3069 | HDLBP | 2 |
10320 | IKZF1 | 1 |
7444 | VRK2 | 3 |
390502 | SERPINA2 | 2 |
56776 | FMN2 | 2 |
23732 | FRRS1L | 1 |
64783 | RBM15 | 3 |
57580 | PREX1 | 1 |
10892 | MALT1 | 2 |
4771 | NF2 | 6 |
23235 | SIK2 | 3 |
6598 | SMARCB1 | 2 |
4170 | MCL1 | 4 |
9651 | PLCH2 | 1 |
1607 | DGKB | 1 |
55203 | LGI2 | 1 |
23213 | SULF1 | 2 |
5218 | CDK14 | 3 |
3066 | HDAC2 | 3 |
10142 | AKAP9 | 2 |
5298 | PI4KB | 3 |
8749 | ADAM18 | 3 |
56936 | CCDC177 | 1 |
55534 | MAML3 | 1 |
341676 | NEK5 | 3 |
1404 | HAPLN1 | 2 |
6318 | SERPINB4 | 2 |
9816 | URB2 | 3 |
140469 | MYO3B | 2 |
604 | BCL6 | 3 |
27147 | DENND2A | 1 |
79934 | COQ8B | 2 |
80122 | MAP3K19 | 3 |
1879 | EBF1 | 1 |
1387 | CREBBP | 6 |
1893 | ECM1 | 3 |
127933 | UHMK1 | 3 |
5788 | PTPRC | 1 |
5579 | PRKCB | 1 |
79858 | NEK11 | 2 |
9048 | ARTN | 2 |
8295 | TRRAP | 7 |
2625 | GATA3 | 1 |
221823 | PRPS1L1 | 2 |
2977 | GUCY1A2 | 1 |
8242 | KDM5C | 1 |
10438 | C1D | 3 |
11122 | PTPRT | 2 |
57156 | TMEM63C | 2 |
6187 | RPS2 | 1 |
4851 | NOTCH1 | 1 |
51512 | GTSE1 | 6 |
139378 | ADGRG4 | 5 |
89910 | UBE3B | 3 |
55294 | FBXW7 | 5 |
974 | CD79B | 3 |
10295 | BCKDK | 3 |
2033 | EP300 | 4 |
8030 | CCDC6 | 3 |
201633 | TIGIT | 1 |
4361 | MRE11 | 2 |
1021 | CDK6 | 1 |
55728 | N4BP2 | 3 |
54477 | PLEKHA5 | 1 |
57670 | KIAA1549 | 3 |
6282 | S100A11 | 2 |
22861 | NLRP1 | 7 |
284521 | OR2L13 | 3 |
440279 | UNC13C | 4 |
4610 | MYCL | 1 |
4301 | AFDN | 3 |
407013 | MIR24-2 | 1 |
57396 | CLK4 | 3 |
342977 | NANOS3 | 1 |
200879 | LIPH | 1 |
2118 | ETV4 | 1 |
11073 | TOPBP1 | 2 |
115703 | ARHGAP33 | 1 |
9079 | LDB2 | 1 |
169436 | STKLD1 | 3 |
11046 | SLC35D2 | 1 |
728264 | CARMN | 1 |
32 | ACACB | 2 |
3556 | IL1RAP | 1 |
534 | ATP6V1G2 | 3 |
4300 | MLLT3 | 2 |
8396 | PIP4K2B | 3 |
64083 | GOLPH3 | 2 |
2830 | GPR6 | 1 |
3091 | HIF1A | 1 |
166614 | DCLK2 | 2 |
6041 | RNASEL | 3 |
80351 | TNKS2 | 4 |
8313 | AXIN2 | 2 |
6091 | ROBO1 | 2 |
30001 | ERO1A | 2 |
2260 | FGFR1 | 3 |
116986 | AGAP2 | 1 |
51343 | FZR1 | 3 |
5330 | PLCB2 | 3 |
80129 | CCDC170 | 2 |
10188 | TNK2 | 3 |
64084 | CLSTN2 | 1 |
103352539 | LINC01410 | 1 |
11169 | WDHD1 | 3 |
1936 | EEF1D | 3 |
83990 | BRIP1 | 1 |
5601 | MAPK9 | 3 |
199745 | THAP8 | 1 |
3688 | ITGB1 | 3 |
9098 | USP6 | 2 |
4194 | MDM4 | 2 |
269 | AMHR2 | 2 |
7424 | VEGFC | 3 |
55681 | SCYL2 | 2 |
171019 | ADAMTS19 | 3 |
4752 | NEK3 | 3 |
7428 | VHL | 1 |
22858 | ICK | 2 |
2064 | ERBB2 | 2 |
282553 | AUTS8 | 1 |
6850 | SYK | 1 |
8643 | PTCH2 | 2 |
65217 | PCDH15 | 6 |
340543 | TCEAL5 | 1 |
7486 | WRN | 2 |
23387 | SIK3 | 2 |
1456 | CSNK1G3 | 3 |
783 | CACNB2 | 2 |
4140 | MARK3 | 3 |
11255 | HRH3 | 1 |
6416 | MAP2K4 | 2 |
9759 | HDAC4 | 2 |
3800 | KIF5C | 1 |
273 | AMPH | 1 |
5286 | PIK3C2A | 3 |
6709 | SPTAN1 | 3 |
1909 | EDNRA | 2 |
158056 | MAMDC4 | 2 |
84985 | FAM83A | 1 |
5591 | PRKDC | 3 |
79705 | LRRK1 | 3 |
5568 | PRKACG | 3 |
8091 | HMGA2 | 3 |
6098 | ROS1 | 2 |
57535 | KIAA1324 | 1 |
2778 | GNAS | 4 |
472 | ATM | 5 |
1009 | CDH11 | 4 |
55760 | DHX32 | 1 |
83903 | HASPIN | 2 |
53942 | CNTN5 | 3 |
5924 | RASGRF2 | 3 |
2734 | GLG1 | 3 |
11344 | TWF2 | 3 |
54986 | ULK4 | 4 |
7533 | YWHAH | 1 |
898 | CCNE1 | 5 |
23152 | CIC | 3 |
2050 | EPHB4 | 3 |
8798 | DYRK4 | 3 |
79442 | LRRC2 | 3 |
10413 | YAP1 | 1 |
2201 | FBN2 | 1 |
1029 | CDKN2A | 11 |
5108 | PCM1 | 3 |
100506775 | LINC01353 | 1 |
285203 | EOGT | 1 |
158798 | AKAP14 | 1 |
861 | RUNX1 | 1 |
11143 | KAT7 | 2 |
11197 | WIF1 | 3 |
5834 | PYGB | 1 |
27445 | PCLO | 1 |
58508 | KMT2C | 4 |
7157 | TP53 | 4 |
2099 | ESR1 | 3 |
6092 | ROBO2 | 2 |
3673 | ITGA2 | 1 |
775 | CACNA1C | 1 |
4855 | NOTCH4 | 5 |
6794 | STK11 | 2 |
2322 | FLT3 | 4 |
25836 | NIPBL | 5 |
8218 | CLTCL1 | 1 |
84678 | KDM2B | 1 |
3791 | KDR | 4 |
2912 | GRM2 | 1 |
8061 | FOSL1 | 1 |
220965 | FAM13C | 1 |
4292 | MLH1 | 4 |
6323 | SCN1A | 1 |
54498 | SMOX | 3 |
225689 | MAPK15 | 3 |
5585 | PKN1 | 3 |
9639 | ARHGEF10 | 1 |
1019 | CDK4 | 1 |
28706 | TRAJ49 | 1 |
84075 | FSCB | 1 |
1045 | CDX2 | 9 |
891 | CCNB1 | 3 |
85481 | PSKH2 | 1 |
5604 | MAP2K1 | 29 |
91683 | SYT12 | 1 |
4917 | NTN3 | 1 |
5597 | MAPK6 | 2 |
7422 | VEGFA | 2 |
7038 | TG | 3 |
369 | ARAF | 2 |
4921 | DDR2 | 1 |
4807 | NHLH1 | 1 |
57105 | CYSLTR2 | 3 |
9312 | KCNB2 | 1 |
55589 | BMP2K | 2 |
65125 | WNK1 | 3 |
6934 | TCF7L2 | 2 |
8601 | RGS20 | 1 |
9108 | MTMR7 | 1 |
653316 | FAM153C | 1 |
7175 | TPR | 2 |
9254 | CACNA2D2 | 1 |
80205 | CHD9 | 4 |
124925 | SEZ6 | 1 |
2081 | ERN1 | 3 |
10499 | NCOA2 | 1 |
4437 | MSH3 | 3 |
8923202 | COX2 | 1 |
6795 | AURKC | 3 |
2071 | ERCC3 | 3 |
2175 | FANCA | 2 |
23469 | PHF3 | 3 |
4089 | SMAD4 | 7 |
51284 | TLR7 | 3 |
6654 | SOS1 | 3 |
4139 | MARK1 | 2 |
7204 | TRIO | 3 |
835 | CASP2 | 3 |
9448 | MAP4K4 | 2 |
285220 | EPHA6 | 2 |
546 | ATRX | 4 |
51366 | UBR5 | 3 |
3417 | IDH1 | 4 |
5297 | PI4KA | 2 |
5069 | PAPPA | 3 |
26579 | MYEOV | 2 |
4214 | MAP3K1 | 2 |
440275 | EIF2AK4 | 2 |
8731 | RNMT | 1 |
9972 | NUP153 | 3 |
50615 | IL21R | 1 |
5290 | PIK3CA | 2 |
1000 | CDH2 | 2 |
1687 | GSDME | 5 |
26524 | LATS2 | 3 |
253260 | RICTOR | 3 |
5045 | FURIN | 2 |
64919 | BCL11B | 1 |
2030 | SLC29A1 | 3 |
675 | BRCA2 | 2 |
151126 | ZNF385B | 1 |
54894 | RNF43 | 1 |
7075 | TIE1 | 3 |
1956 | EGFR | 4 |
6853 | SYN1 | 1 |
3065 | HDAC1 | 3 |
4609 | MYC | 3 |
64333 | ARHGAP9 | 2 |
11064 | CNTRL | 4 |
54206 | ERRFI1 | 1 |
2624 | GATA2 | 3 |
1459 | CSNK2A2 | 2 |
85300 | ATCAY | 1 |
1031 | CDKN2C | 1 |
102465463 | MIR6772 | 1 |
5462 | POU5F1B | 1 |
6776 | STAT5A | 1 |
51265 | CDKL3 | 2 |
3553 | IL1B | 2 |
833 | CARS | 3 |
3914 | LAMB3 | 1 |
2189 | FANCG | 1 |
5156 | PDGFRA | 1 |
3635 | INPP5D | 3 |
375056 | MIA3 | 2 |
10971 | YWHAQ | 5 |
1501 | CTNND2 | 1 |
144203 | OVOS2 | 1 |
7132 | TNFRSF1A | 1 |
3949 | LDLR | 3 |
8819 | SAP30 | 2 |
10266 | RAMP2 | 1 |
6872 | TAF1 | 3 |
79026 | AHNAK | 1 |
673 | BRAF | 13 |
7153 | TOP2A | 3 |
57082 | KNL1 | 2 |
6752 | SSTR2 | 1 |
1981 | EIF4G1 | 2 |
1769 | DNAH8 | 3 |
57150 | SMIM8 | 1 |
81849 | ST6GALNAC5 | 1 |
780 | DDR1 | 3 |
83452 | RAB33B | 2 |
57538 | ALPK3 | 2 |
8924 | HERC2 | 2 |
2078 | ERG | 2 |
6502 | SKP2 | 3 |
120892 | LRRK2 | 1 |
79953 | SYNDIG1 | 1 |
6095 | RORA | 3 |
29844 | TFPT | 2 |
84441 | MAML2 | 3 |
78997 | GDAP1L1 | 1 |
5205 | ATP8B1 | 3 |
8029 | CUBN | 1 |
79856 | SNX22 | 1 |
11184 | MAP4K1 | 1 |
9113 | LATS1 | 2 |
9064 | MAP3K6 | 2 |
2767 | GNA11 | 5 |
100505678 | STARD4-AS1 | 1 |
5294 | PIK3CG | 3 |
56896 | DPYSL5 | 1 |
256309 | CCDC110 | 1 |
106480770 | RNA5SP498 | 1 |
642968 | FAM163B | 2 |
340152 | ZC3H12D | 1 |
23049 | SMG1 | 4 |
1806 | DPYD | 5 |
55521 | TRIM36 | 3 |
1995 | ELAVL3 | 1 |
10752 | CHL1 | 6 |
5728 | PTEN | 3 |
208 | AKT2 | 1 |
5649 | RELN | 1 |
5595 | MAPK3 | 4 |
304 | ANXA2P2 | 2 |
1869 | E2F1 | 1 |
774 | CACNA1B | 1 |
388531 | RGS9BP | 1 |
667 | DST | 1 |
284086 | NEK8 | 2 |
79570 | NKAIN1 | 1 |
53836 | GPR87 | 3 |
23542 | MAPK8IP2 | 3 |
352909 | DNAAF3 | 4 |
8453 | CUL2 | 1 |
6770 | STAR | 3 |
7712 | ZNF157 | 1 |
84219 | WDR24 | 1 |
2324 | FLT4 | 3 |
340547 | VSIG1 | 1 |
177 | AGER | 3 |
658 | BMPR1B | 3 |
1445 | CSK | 6 |
91807 | MYLK3 | 1 |
171023 | ASXL1 | 1 |
5582 | PRKCG | 2 |
3655 | ITGA6 | 1 |
7454 | WAS | 6 |
389206 | BEND4 | 1 |
85415 | RHPN2 | 3 |
64114 | TMBIM1 | 2 |
8028 | MLLT10 | 3 |
2277 | VEGFD | 5 |
23411 | SIRT1 | 3 |
53904 | MYO3A | 1 |
84059 | ADGRV1 | 1 |
125242 | KRT18P8 | 2 |
167838 | TXLNB | 2 |
1027 | CDKN1B | 1 |
9139 | CBFA2T2 | 1 |
8821 | INPP4B | 1 |
57705 | WDFY4 | 1 |
8805 | TRIM24 | 2 |
112885 | PHF21B | 1 |
9943 | OXSR1 | 2 |
6878 | TAF6 | 1 |
286151 | FBXO43 | 2 |
26686 | OR4E2 | 3 |
10595 | ERN2 | 2 |
344905 | ATP13A5 | 2 |
51151 | SLC45A2 | 3 |
5291 | PIK3CB | 7 |
162494 | RHBDL3 | 1 |
10076 | PTPRU | 2 |
7248 | TSC1 | 3 |
84465 | MEGF11 | 1 |
4619 | MYH1 | 1 |
26290 | GALNT8 | 1 |
5581 | PRKCE | 3 |
2690 | GHR | 3 |
860 | RUNX2 | 3 |
1789 | DNMT3B | 2 |
53353 | LRP1B | 3 |
55289 | ACOXL | 2 |
5609 | MAP2K7 | 2 |
1281 | COL3A1 | 2 |
9659 | PDE4DIP | 1 |
9201 | DCLK1 | 1 |
4000 | LMNA | 4 |
283455 | KSR2 | 1 |
6760 | SS18 | 3 |
2776 | GNAQ | 5 |
286530 | P2RY8 | 1 |
220164 | DOK6 | 1 |
79628 | SH3TC2 | 2 |
5587 | PRKD1 | 2 |
56144 | PCDHA4 | 1 |
100421428 | RNGTTP1 | 1 |
285962 | WEE2-AS1 | 1 |
23133 | PHF8 | 1 |
3782 | KCNN3 | 1 |
2321 | FLT1 | 2 |
2131 | EXT1 | 3 |
3717 | JAK2 | 1 |
23139 | MAST2 | 1 |
5506 | PPP1R3A | 2 |
1627 | DBN1 | 2 |
134728 | IRAK1BP1 | 1 |
3709 | ITPR2 | 1 |
8899 | PRPF4B | 3 |
54626 | HES2 | 1 |
4067 | LYN | 2 |
1030 | CDKN2B | 6 |
65267 | WNK3 | 3 |
100862685 | ERVK-19 | 1 |
3984 | LIMK1 | 2 |
4772 | NFATC1 | 6 |
80216 | ALPK1 | 1 |
5932 | RBBP8 | 2 |
3977 | LIFR | 3 |
330 | BIRC3 | 3 |
4261 | CIITA | 4 |
4330 | MN1 | 3 |
84072 | HORMAD1 | 4 |
4033 | LRMP | 1 |
444 | ASPH | 1 |
153020 | RASGEF1B | 1 |
2122 | MECOM | 1 |
51167 | CYB5R4 | 4 |
3815 | KIT | 1 |
5054 | SERPINE1 | 1 |
6653 | SORL1 | 4 |
5452 | POU2F2 | 1 |
79140 | CCDC28B | 1 |
5925 | RB1 | 3 |
4893 | NRAS | 20 |
1209 | CLPTM1 | 1 |
2065 | ERBB3 | 2 |
3691 | ITGB4 | 1 |
60529 | ALX4 | 1 |
7403 | KDM6A | 3 |
4439 | MSH5 | 3 |
2534 | FYN | 2 |
1432 | MAPK14 | 1 |
10644 | IGF2BP2 | 4 |
144453 | BEST3 | 1 |
7040 | TGFB1 | 1 |
9878 | TOX4 | 3 |
57120 | GOPC | 3 |
3480 | IGF1R | 3 |
79728 | PALB2 | 2 |
11086 | ADAM29 | 1 |
142 | PARP1 | 1 |
9262 | STK17B | 3 |
374 | AREG | 1 |
2261 | FGFR3 | 1 |
5567 | PRKACB | 3 |
114792 | KLHL32 | 1 |
55422 | ZNF331 | 3 |
581 | BAX | 3 |
157381 | LINC00964 | 1 |
3092 | HIP1 | 3 |
55746 | NUP133 | 3 |
8321 | FZD1 | 1 |
595 | CCND1 | 2 |
100271584 | RPS27P25 | 1 |
4763 | NF1 | 8 |
1612 | DAPK1 | 2 |
4613 | MYCN | 2 |
6886 | TAL1 | 3 |
10891 | PPARGC1A | 2 |
5288 | PIK3C2G | 3 |
94 | ACVRL1 | 3 |
2044 | EPHA5 | 3 |
5287 | PIK3C2B | 2 |
23031 | MAST3 | 3 |
30811 | HUNK | 6 |
388419 | BTBD17 | 1 |
106479490 | RN7SL734P | 4 |
9076 | CLDN1 | 2 |
1608 | DGKG | 3 |
3265 | HRAS | 3 |
699 | BUB1 | 2 |
4193 | MDM2 | 1 |
7294 | TXK | 2 |
6868 | ADAM17 | 2 |
55193 | PBRM1 | 1 |
29110 | TBK1 | 1 |
1499 | CTNNB1 | 2 |
64328 | XPO4 | 3 |
80128 | TRIM46 | 2 |
56155 | TEX14 | 1 |
5602 | MAPK10 | 1 |
9315 | NREP | 1 |
2533 | FYB1 | 2 |
5268 | SERPINB5 | 1 |
441151 | TMEM151B | 1 |
1795 | DOCK3 | 5 |
2904 | GRIN2B | 3 |
5624 | PROC | 6 |
54014 | BRWD1 | 1 |
Gene in drug-gene network: Network Plot
Models in Selumetinib