iGMDRD399


Canonical SMILES: CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)Cl)C(=O)NOCCO

InChI: InChI=1S/C17H15BrClFN4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

InChI Key: CYOHGALHFOKKQC-UHFFFAOYSA-N

Standard NameCHEMBLPubchem CIDDRUGBANK IDDrug StatusDrug Type
SelumetinibCHEMBL2105684 CHEMBL1614701 10127600DB11689AloneSmall Molecule



Drug Pathways:

ERK MAPK signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
3294HSD17B21
331XIAP2
8618CADPS1
3696ITGB83
1147CHUK2
1105CHD11
4854NOTCH32
7514XPO11
8241RBM101
8999CDKL23
10903MTMR111
471ATIC3
55510DDX431
10641NPRL23
7128TNFAIP33
8444DYRK33
8476CDC42BPA3
11183MAP4K52
114801TMEM200A3
64061TSPYL21
5546PRCC5
2956MSH61
2200FBN13
79767ELMO31
54602NDFIP22
3708ITPR14
103ADAR1
1588CYP19A12
1520CTSS2
80237ELL31
9149DYRK1B3
7272TTK2
347365ITIH67
3845KRAS21
3757KCNH23
100289092ATP2A1-AS12
4750NEK12
5295PIK3R12
100505865LINC009202
8289ARID1A1
80070ADAMTS206
26511CHIC22
2335FN12
4928NUP983
5593PRKG23
53616ADAM222
57709SLC7A141
2475MTOR3
9475ROCK23
27094KCNMB31
83942TSSK1B2
6597SMARCA41
644353ZCCHC182
3326HSP90AB13
9869SETDB14
4036LRP23
7764ZNF2173
353345GPR1414
89866SEC16B1
5133PDCD12
3069HDLBP2
10320IKZF11
7444VRK23
390502SERPINA22
56776FMN22
23732FRRS1L1
64783RBM153
57580PREX11
10892MALT12
4771NF26
23235SIK23
6598SMARCB12
4170MCL14
9651PLCH21
1607DGKB1
55203LGI21
23213SULF12
5218CDK143
3066HDAC23
10142AKAP92
5298PI4KB3
8749ADAM183
56936CCDC1771
55534MAML31
341676NEK53
1404HAPLN12
6318SERPINB42
9816URB23
140469MYO3B2
604BCL63
27147DENND2A1
79934COQ8B2
80122MAP3K193
1879EBF11
1387CREBBP6
1893ECM13
127933UHMK13
5788PTPRC1
5579PRKCB1
79858NEK112
9048ARTN2
8295TRRAP7
2625GATA31
221823PRPS1L12
2977GUCY1A21
8242KDM5C1
10438C1D3
11122PTPRT2
57156TMEM63C2
6187RPS21
4851NOTCH11
51512GTSE16
139378ADGRG45
89910UBE3B3
55294FBXW75
974CD79B3
10295BCKDK3
2033EP3004
8030CCDC63
201633TIGIT1
4361MRE112
1021CDK61
55728N4BP23
54477PLEKHA51
57670KIAA15493
6282S100A112
22861NLRP17
284521OR2L133
440279UNC13C4
4610MYCL1
4301AFDN3
407013MIR24-21
57396CLK43
342977NANOS31
200879LIPH1
2118ETV41
11073TOPBP12
115703ARHGAP331
9079LDB21
169436STKLD13
11046SLC35D21
728264CARMN1
32ACACB2
3556IL1RAP1
534ATP6V1G23
4300MLLT32
8396PIP4K2B3
64083GOLPH32
2830GPR61
3091HIF1A1
166614DCLK22
6041RNASEL3
80351TNKS24
8313AXIN22
6091ROBO12
30001ERO1A2
2260FGFR13
116986AGAP21
51343FZR13
5330PLCB23
80129CCDC1702
10188TNK23
64084CLSTN21
103352539LINC014101
11169WDHD13
1936EEF1D3
83990BRIP11
5601MAPK93
199745THAP81
3688ITGB13
9098USP62
4194MDM42
269AMHR22
7424VEGFC3
55681SCYL22
171019ADAMTS193
4752NEK33
7428VHL1
22858ICK2
2064ERBB22
282553AUTS81
6850SYK1
8643PTCH22
65217PCDH156
340543TCEAL51
7486WRN2
23387SIK32
1456CSNK1G33
783CACNB22
4140MARK33
11255HRH31
6416MAP2K42
9759HDAC42
3800KIF5C1
273AMPH1
5286PIK3C2A3
6709SPTAN13
1909EDNRA2
158056MAMDC42
84985FAM83A1
5591PRKDC3
79705LRRK13
5568PRKACG3
8091HMGA23
6098ROS12
57535KIAA13241
2778GNAS4
472ATM5
1009CDH114
55760DHX321
83903HASPIN2
53942CNTN53
5924RASGRF23
2734GLG13
11344TWF23
54986ULK44
7533YWHAH1
898CCNE15
23152CIC3
2050EPHB43
8798DYRK43
79442LRRC23
10413YAP11
2201FBN21
1029CDKN2A11
5108PCM13
100506775LINC013531
285203EOGT1
158798AKAP141
861RUNX11
11143KAT72
11197WIF13
5834PYGB1
27445PCLO1
58508KMT2C4
7157TP534
2099ESR13
6092ROBO22
3673ITGA21
775CACNA1C1
4855NOTCH45
6794STK112
2322FLT34
25836NIPBL5
8218CLTCL11
84678KDM2B1
3791KDR4
2912GRM21
8061FOSL11
220965FAM13C1
4292MLH14
6323SCN1A1
54498SMOX3
225689MAPK153
5585PKN13
9639ARHGEF101
1019CDK41
28706TRAJ491
84075FSCB1
1045CDX29
891CCNB13
85481PSKH21
5604MAP2K129
91683SYT121
4917NTN31
5597MAPK62
7422VEGFA2
7038TG3
369ARAF2
4921DDR21
4807NHLH11
57105CYSLTR23
9312KCNB21
55589BMP2K2
65125WNK13
6934TCF7L22
8601RGS201
9108MTMR71
653316FAM153C1
7175TPR2
9254CACNA2D21
80205CHD94
124925SEZ61
2081ERN13
10499NCOA21
4437MSH33
8923202COX21
6795AURKC3
2071ERCC33
2175FANCA2
23469PHF33
4089SMAD47
51284TLR73
6654SOS13
4139MARK12
7204TRIO3
835CASP23
9448MAP4K42
285220EPHA62
546ATRX4
51366UBR53
3417IDH14
5297PI4KA2
5069PAPPA3
26579MYEOV2
4214MAP3K12
440275EIF2AK42
8731RNMT1
9972NUP1533
50615IL21R1
5290PIK3CA2
1000CDH22
1687GSDME5
26524LATS23
253260RICTOR3
5045FURIN2
64919BCL11B1
2030SLC29A13
675BRCA22
151126ZNF385B1
54894RNF431
7075TIE13
1956EGFR4
6853SYN11
3065HDAC13
4609MYC3
64333ARHGAP92
11064CNTRL4
54206ERRFI11
2624GATA23
1459CSNK2A22
85300ATCAY1
1031CDKN2C1
102465463MIR67721
5462POU5F1B1
6776STAT5A1
51265CDKL32
3553IL1B2
833CARS3
3914LAMB31
2189FANCG1
5156PDGFRA1
3635INPP5D3
375056MIA32
10971YWHAQ5
1501CTNND21
144203OVOS21
7132TNFRSF1A1
3949LDLR3
8819SAP302
10266RAMP21
6872TAF13
79026AHNAK1
673BRAF13
7153TOP2A3
57082KNL12
6752SSTR21
1981EIF4G12
1769DNAH83
57150SMIM81
81849ST6GALNAC51
780DDR13
83452RAB33B2
57538ALPK32
8924HERC22
2078ERG2
6502SKP23
120892LRRK21
79953SYNDIG11
6095RORA3
29844TFPT2
84441MAML23
78997GDAP1L11
5205ATP8B13
8029CUBN1
79856SNX221
11184MAP4K11
9113LATS12
9064MAP3K62
2767GNA115
100505678STARD4-AS11
5294PIK3CG3
56896DPYSL51
256309CCDC1101
106480770RNA5SP4981
642968FAM163B2
340152ZC3H12D1
23049SMG14
1806DPYD5
55521TRIM363
1995ELAVL31
10752CHL16
5728PTEN3
208AKT21
5649RELN1
5595MAPK34
304ANXA2P22
1869E2F11
774CACNA1B1
388531RGS9BP1
667DST1
284086NEK82
79570NKAIN11
53836GPR873
23542MAPK8IP23
352909DNAAF34
8453CUL21
6770STAR3
7712ZNF1571
84219WDR241
2324FLT43
340547VSIG11
177AGER3
658BMPR1B3
1445CSK6
91807MYLK31
171023ASXL11
5582PRKCG2
3655ITGA61
7454WAS6
389206BEND41
85415RHPN23
64114TMBIM12
8028MLLT103
2277VEGFD5
23411SIRT13
53904MYO3A1
84059ADGRV11
125242KRT18P82
167838TXLNB2
1027CDKN1B1
9139CBFA2T21
8821INPP4B1
57705WDFY41
8805TRIM242
112885PHF21B1
9943OXSR12
6878TAF61
286151FBXO432
26686OR4E23
10595ERN22
344905ATP13A52
51151SLC45A23
5291PIK3CB7
162494RHBDL31
10076PTPRU2
7248TSC13
84465MEGF111
4619MYH11
26290GALNT81
5581PRKCE3
2690GHR3
860RUNX23
1789DNMT3B2
53353LRP1B3
55289ACOXL2
5609MAP2K72
1281COL3A12
9659PDE4DIP1
9201DCLK11
4000LMNA4
283455KSR21
6760SS183
2776GNAQ5
286530P2RY81
220164DOK61
79628SH3TC22
5587PRKD12
56144PCDHA41
100421428RNGTTP11
285962WEE2-AS11
23133PHF81
3782KCNN31
2321FLT12
2131EXT13
3717JAK21
23139MAST21
5506PPP1R3A2
1627DBN12
134728IRAK1BP11
3709ITPR21
8899PRPF4B3
54626HES21
4067LYN2
1030CDKN2B6
65267WNK33
100862685ERVK-191
3984LIMK12
4772NFATC16
80216ALPK11
5932RBBP82
3977LIFR3
330BIRC33
4261CIITA4
4330MN13
84072HORMAD14
4033LRMP1
444ASPH1
153020RASGEF1B1
2122MECOM1
51167CYB5R44
3815KIT1
5054SERPINE11
6653SORL14
5452POU2F21
79140CCDC28B1
5925RB13
4893NRAS20
1209CLPTM11
2065ERBB32
3691ITGB41
60529ALX41
7403KDM6A3
4439MSH53
2534FYN2
1432MAPK141
10644IGF2BP24
144453BEST31
7040TGFB11
9878TOX43
57120GOPC3
3480IGF1R3
79728PALB22
11086ADAM291
142PARP11
9262STK17B3
374AREG1
2261FGFR31
5567PRKACB3
114792KLHL321
55422ZNF3313
581BAX3
157381LINC009641
3092HIP13
55746NUP1333
8321FZD11
595CCND12
100271584RPS27P251
4763NF18
1612DAPK12
4613MYCN2
6886TAL13
10891PPARGC1A2
5288PIK3C2G3
94ACVRL13
2044EPHA53
5287PIK3C2B2
23031MAST33
30811HUNK6
388419BTBD171
106479490RN7SL734P4
9076CLDN12
1608DGKG3
3265HRAS3
699BUB12
4193MDM21
7294TXK2
6868ADAM172
55193PBRM11
29110TBK11
1499CTNNB12
64328XPO43
80128TRIM462
56155TEX141
5602MAPK101
9315NREP1
2533FYB12
5268SERPINB51
441151TMEM151B1
1795DOCK35
2904GRIN2B3
5624PROC6
54014BRWD11

Gene in drug-gene network: Network Plot

Models in Selumetinib

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