ITGA2
Summary: This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| integrin subunit alpha 2 | MIM:192974 | Ensembl:ENSG00000164171 | HGNC:HGNC:6137 | PA204 | 5q11.2 |
GO terms in ITGA2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0001540 | amyloid-beta binding |
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IEA | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IMP | GO:0005518 | collagen binding |
| MF | IMP | GO:0038064 | collagen receptor activity |
| MF | IEA | GO:0043236 | laminin binding |
| MF | TAS | GO:0043395 | heparan sulfate proteoglycan binding |
| MF | IPI | GO:0044877 | protein-containing complex binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| MF | IMP | GO:0098639 | collagen binding involved in cell-matrix adhesion |
| CC | IEA | GO:0005634 | nucleus |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | TAS | GO:0008305 | integrin complex |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | HDA | GO:0009986 | cell surface |
| CC | IDA | GO:0009986 | cell surface |
| CC | IDA | GO:0034666 | integrin alpha2-beta1 complex |
| CC | IEA | GO:0043679 | axon terminus |
| CC | IEA | GO:0045178 | basal part of cell |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | IEA | GO:0002687 | positive regulation of leukocyte migration |
| BP | IMP | GO:0006929 | substrate-dependent cell migration |
| BP | IEA | GO:0006971 | hypotonic response |
| BP | TAS | GO:0007155 | cell adhesion |
| BP | IMP | GO:0007160 | cell-matrix adhesion |
| BP | IMP | GO:0007229 | integrin-mediated signaling pathway |
| BP | IEA | GO:0007565 | female pregnancy |
| BP | TAS | GO:0007596 | blood coagulation |
| BP | IEA | GO:0008283 | cell proliferation |
| BP | TAS | GO:0009887 | animal organ morphogenesis |
| BP | IEA | GO:0010634 | positive regulation of epithelial cell migration |
| BP | IEA | GO:0010694 | positive regulation of alkaline phosphatase activity |
| BP | IEA | GO:0014075 | response to amine |
| BP | IEA | GO:0014850 | response to muscle activity |
| BP | IEA | GO:0014911 | positive regulation of smooth muscle cell migration |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | IEA | GO:0030879 | mammary gland development |
| BP | IEA | GO:0031346 | positive regulation of cell projection organization |
| BP | IMP | GO:0031589 | cell-substrate adhesion |
| BP | IEA | GO:0032967 | positive regulation of collagen biosynthetic process |
| BP | IEA | GO:0033343 | positive regulation of collagen binding |
| BP | IEA | GO:0033591 | response to L-ascorbic acid |
| BP | IMP | GO:0033627 | cell adhesion mediated by integrin |
| BP | IMP | GO:0038065 | collagen-activated signaling pathway |
| BP | IEA | GO:0042493 | response to drug |
| BP | IEA | GO:0043388 | positive regulation of DNA binding |
| BP | IEA | GO:0043589 | skin morphogenesis |
| BP | IEA | GO:0045184 | establishment of protein localization |
| BP | IEA | GO:0045727 | positive regulation of translation |
| BP | IEA | GO:0045785 | positive regulation of cell adhesion |
| BP | IEA | GO:0045987 | positive regulation of smooth muscle contraction |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | IEA | GO:0048041 | focal adhesion assembly |
| BP | IEP | GO:0048333 | mesodermal cell differentiation |
| BP | IEA | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| BP | IEA | GO:0050729 | positive regulation of inflammatory response |
| BP | IEA | GO:0050927 | positive regulation of positive chemotaxis |
| BP | IEA | GO:0050966 | detection of mechanical stimulus involved in sensory perception of pain |
| BP | IEA | GO:0051971 | positive regulation of transmission of nerve impulse |
| BP | IEA | GO:0060100 | positive regulation of phagocytosis, engulfment |
| BP | IEA | GO:0070365 | hepatocyte differentiation |
| BP | IEA | GO:0071107 | response to parathyroid hormone |
| BP | IEA | GO:0071260 | cellular response to mechanical stimulus |
| BP | IEA | GO:0071392 | cellular response to estradiol stimulus |
Gene expression in normal tissue: ITGA2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ITGA2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-3000157 | Laminin interactions |
| reactome | R-HSA-3000157 | Laminin interactions |
| reactome | R-HSA-3000170 | Syndecan interactions |
| reactome | R-HSA-3000171 | Non-integrin membrane-ECM interactions |
| reactome | R-HSA-3000178 | ECM proteoglycans |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-447041 | CHL1 interactions |
| reactome | R-HSA-6806834 | Signaling by MET |
| reactome | R-HSA-75892 | Platelet Adhesion to exposed collagen |
| reactome | R-HSA-8874081 | MET activates PTK2 signaling |
| reactome | R-HSA-8875878 | MET promotes cell motility |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2118 | Arrhythmogenic Right Ventricular Cardiomyopathy |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP2806 | Human Complement System |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| pid | arf6_traffickingpathway | Arf6 trafficking events |
| pid | integrin1_pathway | Beta1 integrin cell surface interactions |
| pid | lymphangiogenesis_pathway | VEGFR3 signaling in lymphatic endothelium |
| pid | plexind1_pathway | Plexin-D1 Signaling |
| pid | syndecan_2_pathway | Syndecan-2-mediated signaling events |
| pharmgkb | PA154444041 | Platelet Aggregation Inhibitor Pathway, Pharmacodynamics |
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04512 | ECM-receptor interaction - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05410 | Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) |
| kegg | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) |
| kegg | hsa05414 | Dilated cardiomyopathy (DCM) - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD1 | Nicotin-Amide | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD232 | FTI-277 | 1 |
| iGMDRD1036 | X17AAG | 2 |
| iGMDRD112 | Methotrexate | 1 |
| iGMDRD12 | Bicalutamide | 1 |
| iGMDRD659 | Avagacestat (BMS-708163) | 1 |
| iGMDRD324 | CI-1040 | 1 |
| iGMDRD470 | Trametinib | 1 |
| iGMDRD401 | Afatinib | 1 |
| iGMDRD548 | Marinopyrrole A | 1 |
| iGMDRD608 | Refametinib | 2 |
| iGMDRD604 | 4449-51-8 | 1 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD284 | Palbociclib | 1 |
| iGMDRD117 | Docetaxel | 1 |
| iGMDRD468 | AZ628 | 1 |
| iGMDRD478 | ABT-888 | 1 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD244 | ML311 | 1 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD33 | Entinostat | 1 |
| iGMDRD472 | PF-562271 | 1 |
| iGMDRD225 | AC1MD3YP | 1 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD399 | Selumetinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ITGA2
CLASSFICATION
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