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iGMDRD546

Canonical SMILES: CC1(CCCN1C2=NN3C=CC=C3C(=N2)NC4=NNC(=C4)C5CC5)C(=O)NC6=CN=C(C=C6)F

InChI: InChI=1S/C23H24FN9O/c1-23(21(34)26-15-7-8-18(24)25-13-15)9-3-10-32(23)22-28-20(17-4-2-11-33(17)31-22)27-19-12-16(29-30-19)14-5-6-14/h2,4,7-8,11-14H,3,5-6,9-10H2,1H3,(H,26,34)(H2,27,28,29,30,31)/t23-/m0/s1

InChI Key: LQVXSNNAFNGRAH-QHCPKHFHSA-N

Standard Name	CHEMBL	Pubchem CID	Drug Status	Drug Type
BMS-754807	CHEMBL2401777 CHEMBL575448	24785500	Alone	Small Molecule

Drug Targets:

IGF1R IR

Drug Pathways:

IGFR signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
8241	RBM10	1
8019	BRD3	2
10460	TACC3	1
6491	STIL	2
132	ADK	3
6774	STAT3	6
11183	MAP4K5	4
5546	PRCC	3
2956	MSH6	1
3708	ITPR1	1
1588	CYP19A1	3
1520	CTSS	3
3845	KRAS	2
3757	KCNH2	6
4750	NEK1	2
5295	PIK3R1	2
8289	ARID1A	4
80070	ADAMTS20	1
8573	CASK	1
25778	DSTYK	3
4928	NUP98	3
6597	SMARCA4	1
150209	AIFM3	3
3551	IKBKB	2
9869	SETDB1	2
4036	LRP2	2
8780	RIOK3	3
7764	ZNF217	2
353345	GPR141	5
5754	PTK7	2
4771	NF2	3
23235	SIK2	3
1136	CHRNA3	3
3320	HSP90AA1	2
3066	HDAC2	3
10142	AKAP9	3
7253	TSHR	3
5298	PI4KB	3
6318	SERPINB4	5
9816	URB2	6
51199	NIN	5
114783	LMTK3	4
1387	CREBBP	2
26039	SS18L1	2
1859	DYRK1A	6
23225	NUP210	3
2313	FLI1	1
5579	PRKCB	2
31	ACACA	2
10178	TENM1	4
5966	REL	2
29998	BICRA	1
2977	GUCY1A2	3
10438	C1D	2
11122	PTPRT	2
9024	BRSK2	4
4851	NOTCH1	1
2120	ETV6	3
5314	PKHD1	2
51512	GTSE1	6
89910	UBE3B	3
55294	FBXW7	1
974	CD79B	3
10295	BCKDK	3
8784	TNFRSF18	3
9578	CDC42BPB	1
440279	UNC13C	2
4610	MYCL	3
2115	ETV1	1
84033	OBSCN	2
25937	WWTR1	1
1880	GPR183	3
57787	MARK4	3
4478	MSN	3
5613	PRKX	2
9175	MAP3K13	2
2260	FGFR1	3
5330	PLCB2	3
114548	NLRP3	8
2210	FCGR1B	1
11169	WDHD1	3
695	BTK	2
2908	NR3C1	2
83990	BRIP1	6
51804	SIX4	2
269	AMHR2	2
7424	VEGFC	3
83931	STK40	2
207	AKT1	3
238	ALK	2
22858	ICK	4
2064	ERBB2	1
85443	DCLK3	2
6850	SYK	3
65217	PCDH15	3
4294	MAP3K10	3
9759	HDAC4	4
158056	MAMDC4	1
6464	SHC1	3
9472	AKAP6	2
3685	ITGAV	3
6917	TCEA1	3
3667	IRS1	1
4605	MYBL2	2
139285	AMER1	1
83903	HASPIN	3
53942	CNTN5	2
84433	CARD11	2
9096	TBX18	3
4058	LTK	2
6792	CDKL5	2
5450	POU2AF1	2
91461	PKDCC	6
2066	ERBB4	4
8798	DYRK4	3
5863	RGL2	4
10413	YAP1	1
7184	HSP90B1	2
157753	TMEM74	3
5336	PLCG2	3
27347	STK39	1
7157	TP53	7
2099	ESR1	3
3673	ITGA2	1
6794	STK11	1
4857	NOVA1	4
5910	RAP1GDS1	6
3791	KDR	4
3000	GUCY2D	2
225689	MAPK15	3
9639	ARHGEF10	3
1019	CDK4	3
8874	ARHGEF7	2
1102	RCBTB2	2
57105	CYSLTR2	3
65125	WNK1	3
6934	TCF7L2	1
4436	MSH2	2
652	BMP4	2
1656	DDX6	2
984	CDK11B	3
2081	ERN1	6
84181	CHD6	1
4026	LPP	1
8923202	COX2	1
7994	KAT6A	3
54658	UGT1A1	1
6654	SOS1	3
672	BRCA1	1
10948	STARD3	2
256536	TCERG1L	4
5727	PTCH1	4
285220	EPHA6	2
546	ATRX	1
5069	PAPPA	3
10769	PLK2	2
7270	TTF1	1
9972	NUP153	2
26524	LATS2	1
64919	BCL11B	2
7075	TIE1	3
1956	EGFR	2
4609	MYC	6
54206	ERRFI1	1
91	ACVR1B	1
5599	MAPK8	3
8021	NUP214	5
5753	PTK6	3
4684	NCAM1	2
6885	MAP3K7	1
26278	SACS	2
5462	POU5F1B	2
6776	STAT5A	2
3553	IL1B	1
8900	CCNA1	3
375056	MIA3	2
7189	TRAF6	3
203102	ADAM32	2
84879	MFSD2A	2
3315	HSPB1	2
4863	NPAT	3
89795	NAV3	3
29844	TFPT	2
5205	ATP8B1	1
9113	LATS1	3
7849	PAX8	2
9509	ADAMTS2	2
23598	PATZ1	1
23049	SMG1	2
10010	TANK	2
5728	PTEN	4
51592	TRIM33	2
5595	MAPK3	3
1869	E2F1	4
80124	VCPIP1	2
100187828	HBD	3
23281	MTUS2	3
115701	ALPK2	4
284086	NEK8	1
53836	GPR87	2
5347	PLK1	3
140803	TRPM6	2
890	CCNA2	3
177	AGER	3
5896	RAG1	3
28954	REM1	1
1445	CSK	3
2277	VEGFD	3
23411	SIRT1	3
53904	MYO3A	2
387	RHOA	2
79012	CAMKV	2
3161	HMMR	2
54861	SNRK	1
2046	EPHA8	1
8821	INPP4B	2
221895	JAZF1	2
23305	ACSL6	2
344905	ATP13A5	2
4297	KMT2A	1
7385	UQCRC2	1
558	AXL	2
9748	SLK	2
2690	GHR	4
2317	FLNB	2
171389	NLRP6	3
53353	LRP1B	2
55289	ACOXL	2
1281	COL3A1	2
2185	PTK2B	3
63976	PRDM16	2
283455	KSR2	1
3557	IL1RN	3
3624	INHBA	3
5587	PRKD1	1
4215	MAP3K3	3
5583	PRKCH	4
5170	PDPK1	1
6196	RPS6KA2	4
57448	BIRC6	2
23139	MAST2	3
1627	DBN1	4
79837	PIP4K2C	3
3709	ITPR2	2
8899	PRPF4B	2
100862685	ERVK-19	1
84254	CAMKK1	3
5603	MAPK13	3
8428	STK24	2
5932	RBBP8	2
5915	RARB	2
7112	TMPO	3
4261	CIITA	6
3656	IRAK2	1
170685	NUDT10	3
5925	RB1	5
4217	MAP3K5	2
4893	NRAS	5
1209	CLPTM1	2
63923	TNN	3
2074	ERCC6	2
54790	TET2	3
112268437	LOC112268437	2
4638	MYLK	2
7040	TGFB1	1
55959	SULF2	2
9878	TOX4	4
3480	IGF1R	2
51135	IRAK4	1
11086	ADAM29	3
142	PARP1	4
2261	FGFR3	6
3237	HOXD11	3
4040	LRP6	3
9625	AATK	2
63893	UBE2O	3
94	ACVRL1	7
5287	PIK3C2B	4
4593	MUSK	1
30811	HUNK	6
1608	DGKG	5
4193	MDM2	2
4780	NFE2L2	1
23112	TNRC6B	4
2178	FANCE	2
27255	CNTN6	2
29110	TBK1	2
56155	TEX14	5
2886	GRB7	3
1795	DOCK3	3
5624	PROC	3
5970	RELA	2

Gene in drug-gene network: Network Plot

Models in BMS-754807

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.