JAZF1
Summary: This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| JAZF zinc finger 1 | MIM:606246 | Ensembl:ENSG00000153814 | HGNC:HGNC:28917 | PA162392484 | 7p15.2-p15.1 |
GO terms in JAZF1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006629 | lipid metabolic process |
| CC | IDA | GO:0001650 | fibrillar center |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0017053 | transcriptional repressor complex |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0003676 | nucleic acid binding |
| MF | IDA | GO:0003714 | transcription corepressor activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: JAZF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in JAZF1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD248 | BRD4354 | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD100 | Zebularine | 5 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD872 | BRD7137 | 5 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD137 | Indisulam | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in JAZF1
CLASSFICATION
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