JAZF1


Summary: This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
JAZF zinc finger 1MIM:606246Ensembl:ENSG00000153814HGNC:HGNC:28917PA1623924847p15.2-p15.1

GO terms in JAZF1


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006629lipid metabolic process
CCIDAGO:0001650fibrillar center
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005829cytosol
CCIDAGO:0017053transcriptional repressor complex
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0003676nucleic acid binding
MFIDAGO:0003714transcription corepressor activity
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: JAZF1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in JAZF1


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD314Tanespimycin3
iGMDRD193Fqi12
iGMDRD123Isoevodiamine2
iGMDRD512nutlin 32
iGMDRD248BRD43542
iGMDRD1008SR-II-138A2
iGMDRD532Olaparib3
iGMDRD546BMS-7548072
iGMDRD398Sepantronium2
iGMDRD367Ro 28-16752
iGMDRD871BRD63686
iGMDRD100Zebularine5
iGMDRD74Idarubicin3
iGMDRD872BRD71375
iGMDRD887Compound 23 citrate2
iGMDRD356PNU-746542
iGMDRD451Serdemetan3
iGMDRD300Tozasertib3
iGMDRD64Parbendazole2
iGMDRD158NSC1415402
iGMDRD137Indisulam2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in JAZF1

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