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iGMDRD512

Canonical SMILES: CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

InChI: InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m1/s1

InChI Key: BDUHCSBCVGXTJM-IZLXSDGUSA-N

Standard Name	CHEMBL	Pubchem CID	Drug Status	Drug Type
nutlin 3	CHEMBL191334	16755600	Alone	Small Molecule

Drug Targets:

MDM2

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
1105	CHD1	2
27125	AFF4	3
4854	NOTCH3	2
3725	JUN	1
10460	TACC3	3
81037	CLPTM1L	3
5027	P2RX7	2
10903	MTMR11	4
7837	PXDN	9
10221	TRIB1	3
1464	CSPG4	1
7128	TNFAIP3	2
21	ABCA3	3
132	ADK	2
7161	TP73	3
7750	ZMYM2	1
11183	MAP4K5	4
2048	EPHB2	3
79947	DHDDS	1
4627	MYH9	2
5546	PRCC	2
8929	PHOX2B	3
23513	SCRIB	5
2956	MSH6	3
4303	FOXO4	2
57679	ALS2	3
150465	TTL	4
3708	ITPR1	3
1588	CYP19A1	2
1969	EPHA2	2
9706	ULK2	4
7272	TTK	2
93	ACVR2B	3
3757	KCNH2	1
4750	NEK1	1
6351	CCL4	1
80070	ADAMTS20	3
701	BUB1B	2
3939	LDHA	1
25778	DSTYK	3
9760	TOX	2
9475	ROCK2	4
83942	TSSK1B	3
6597	SMARCA4	5
3551	IKBKB	3
81035	COLEC12	3
3326	HSP90AB1	3
9869	SETDB1	1
4036	LRP2	2
11160	ERLIN2	4
5133	PDCD1	1
3069	HDLBP	3
10320	IKZF1	2
29888	STRN4	3
390502	SERPINA2	3
5754	PTK7	3
5079	PAX5	5
51684	SUFU	4
4313	MMP2	1
10863	ADAM28	2
23213	SULF1	4
1272	CNTN1	3
9641	IKBKE	3
5218	CDK14	3
10142	AKAP9	2
22853	LMTK2	5
7253	TSHR	1
23310	NCAPD3	1
5298	PI4KB	3
2241	FER	1
341676	NEK5	4
57172	CAMK1G	1
4092	SMAD7	3
6455	SH3GL1	3
6887	TAL2	3
23612	PHLDA3	1
7048	TGFBR2	1
28231	SLCO4A1	1
114783	LMTK3	1
202374	STK32A	1
5756	TWF1	3
23225	NUP210	1
10013	HDAC6	3
5579	PRKCB	5
31	ACACA	3
1602	DACH1	5
10178	TENM1	4
51755	CDK12	2
57472	CNOT6	3
5966	REL	5
9411	ARHGAP29	3
8295	TRRAP	2
1111	CHEK1	1
26576	SRPK3	3
2977	GUCY1A2	4
10438	C1D	2
11122	PTPRT	3
23617	TSSK2	5
27148	STK36	4
55300	PI4K2B	3
2120	ETV6	3
139378	ADGRG4	3
10295	BCKDK	1
2033	EP300	3
8784	TNFRSF18	3
4001	LMNB1	1
641	BLM	6
4361	MRE11	2
5914	RARA	6
64324	NSD1	1
83439	TCF7L1	2
1454	CSNK1E	2
23522	KAT6B	3
54477	PLEKHA5	3
22861	NLRP1	4
440279	UNC13C	3
4610	MYCL	1
27065	NSG1	1
2115	ETV1	3
5081	PAX7	3
55819	RNF130	3
5607	MAP2K5	3
256646	NUTM1	4
1880	GPR183	6
122011	CSNK1A1L	1
3621	ING1	1
9693	RAPGEF2	1
222484	LNX2	6
8549	LGR5	2
6256	RXRA	4
32	ACACB	1
8852	AKAP4	6
26353	HSPB8	1
22806	IKZF3	1
2242	FES	3
166614	DCLK2	1
3645	INSRR	2
200576	PIKFYVE	1
80351	TNKS2	3
8313	AXIN2	7
6733	SRPK2	2
1050	CEBPA	4
2260	FGFR1	3
116986	AGAP2	2
51343	FZR1	4
23255	MTCL1	3
114548	NLRP3	2
10188	TNK2	2
2736	GLI2	3
29904	EEF2K	3
1936	EEF1D	3
83990	BRIP1	2
51804	SIX4	3
3688	ITGB1	6
6928	HNF1B	3
4194	MDM4	1
83931	STK40	2
207	AKT1	6
4982	TNFRSF11B	3
1992	SERPINB1	1
238	ALK	2
7078	TIMP3	3
171019	ADAMTS19	1
375449	MAST4	2
83983	TSSK6	3
6663	SOX10	3
834	CASP1	3
993	CDC25A	2
29775	CARD10	3
23191	CYFIP1	1
23387	SIK3	5
338322	NLRP10	3
783	CACNB2	3
9131	AIFM1	3
5127	CDK16	3
9759	HDAC4	3
25989	ULK3	3
8215	DVL1P1	1
1973	EIF4A1	6
50488	MINK1	1
5591	PRKDC	1
79705	LRRK1	3
5568	PRKACG	2
2778	GNAS	1
3667	IRS1	4
80243	PREX2	4
5165	PDK3	6
1009	CDH11	3
139285	AMER1	2
28996	HIPK2	6
575	ADGRB1	2
5924	RASGRF2	1
6792	CDKL5	2
1496	CTNNA2	3
898	CCNE1	2
23152	CIC	1
7867	MAPKAPK3	1
7681	MKRN3	2
839	CASP6	3
5863	RGL2	3
9319	TRIP13	4
2201	FBN2	2
7184	HSP90B1	1
10062	NR1H3	4
9794	MAML1	2
57523	NYNRIN	3
8576	STK16	3
861	RUNX1	2
9874	TLK1	3
28514	DLL1	1
64393	ZMAT3	1
3932	LCK	3
58508	KMT2C	5
7157	TP53	1
6092	ROBO2	1
79058	ASPSCR1	2
6794	STK11	3
57194	ATP10A	5
25836	NIPBL	2
7869	SEMA3B	5
5910	RAP1GDS1	3
3791	KDR	1
10114	HIPK3	4
836	CASP3	3
4292	MLH1	2
6772	STAT1	3
114788	CSMD3	1
2263	FGFR2	3
7249	TSC2	2
1019	CDK4	3
7409	VAV1	3
84075	FSCB	3
1045	CDX2	2
105	ADARB2	3
4869	NPM1	1
344387	CDKL4	3
51086	TNNI3K	2
55034	MOCOS	3
64847	SPATA20	1
10516	FBLN5	3
9088	PKMYT1	3
5600	MAPK11	2
55437	STRADB	3
369	ARAF	2
4921	DDR2	3
9965	FGF19	3
3187	HNRNPH1	4
65125	WNK1	4
136332	LRGUK	1
50945	TBX22	1
652	BMP4	6
1656	DDX6	1
1441	CSF3R	1
54106	TLR9	3
80205	CHD9	4
8115	TCL1A	3
2081	ERN1	3
4026	LPP	3
8997	KALRN	3
2071	ERCC3	3
57551	TAOK1	1
3559	IL2RA	3
6654	SOS1	4
672	BRCA1	2
2737	GLI3	1
7204	TRIO	2
9252	RPS6KA5	3
10733	PLK4	3
78989	COLEC11	5
23373	CRTC1	4
5727	PTCH1	1
9448	MAP4K4	6
285220	EPHA6	4
546	ATRX	3
51366	UBR5	3
3426	CFI	2
3417	IDH1	2
23678	SGK3	2
6134	RPL10	3
7786	MAP3K12	1
56997	COQ8A	3
57144	PAK5	2
340533	NEXMIF	6
5578	PRKCA	4
440275	EIF2AK4	3
1198	CLK3	1
9972	NUP153	2
5290	PIK3CA	6
3720	JARID2	3
2931	GSK3A	4
4293	MAP3K9	5
90	ACVR1	1
5366	PMAIP1	3
5045	FURIN	4
7043	TGFB3	4
85366	MYLK2	3
2318	FLNC	2
64919	BCL11B	2
5530	PPP3CA	2
2030	SLC29A1	3
675	BRCA2	3
607	BCL9	6
28958	COA3	3
7075	TIE1	2
1956	EGFR	12
841	CASP8	2
4609	MYC	1
64750	SMURF2	2
2624	GATA2	6
8021	NUP214	2
1459	CSNK2A2	2
4684	NCAM1	5
6885	MAP3K7	3
26278	SACS	2
5462	POU5F1B	3
1440	CSF3	3
29951	PDZRN4	3
6776	STAT5A	6
51701	NLK	2
2189	FANCG	3
5156	PDGFRA	3
3635	INPP5D	3
1653	DDX1	3
8900	CCNA1	4
375056	MIA3	4
137872	ADHFE1	3
27330	RPS6KA6	3
3949	LDLR	1
7015	TERT	3
10186	LHFPL6	2
673	BRAF	5
7153	TOP2A	5
57082	KNL1	4
1213	CLTC	4
4790	NFKB1	3
6011	GRK1	1
22976	PAXIP1	3
23532	PRAME	4
83452	RAB33B	3
57538	ALPK3	5
5598	MAPK7	2
8924	HERC2	4
2078	ERG	3
6469	SHH	3
339345	NANOS2	2
120892	LRRK2	2
89795	NAV3	3
65268	WNK2	2
11126	CD160	4
2867	FFAR2	3
867	CBL	4
60401	EDA2R	1
6095	RORA	2
29844	TFPT	5
146057	TTBK2	3
57507	ZNF608	5
5205	ATP8B1	2
7468	NSD2	4
8626	TP63	5
8178	ELL	3
9064	MAP3K6	4
4298	MLLT1	4
5979	RET	4
9321	TRIP11	3
654780	LOC654780	3
664	BNIP3	3
4853	NOTCH2	3
162968	ZNF497	3
266747	RGL4	1
3229	HOXC13	3
23598	PATZ1	3
5563	PRKAA2	1
23049	SMG1	5
10010	TANK	3
55521	TRIM36	3
10752	CHL1	2
5728	PTEN	3
57521	RPTOR	2
208	AKT2	3
1487	CTBP1	3
164668	APOBEC3H	2
5595	MAPK3	3
8888	MCM3AP	5
55120	FANCL	3
80124	VCPIP1	1
22883	CLSTN1	3
667	DST	4
23281	MTUS2	3
115701	ALPK2	1
5594	MAPK1	6
5347	PLK1	4
352909	DNAAF3	6
2324	FLT4	3
1950	EGF	1
2264	FGFR4	7
177	AGER	3
9344	TAOK2	2
6498	SKIL	1
7273	TTN	2
79834	PEAK1	3
5582	PRKCG	3
6789	STK4	5
23332	CLASP1	6
7059	THBS3	3
10257	ABCC4	3
85415	RHPN2	3
23389	MED13L	2
8028	MLLT10	6
55359	STYK1	3
8648	NCOA1	1
29941	PKN3	3
128869	PIGU	1
10243	GPHN	3
221895	JAZF1	2
84930	MASTL	4
8805	TRIM24	4
22843	PPM1E	2
8394	PIP5K1A	4
65018	PINK1	1
2353	FOS	4
1662	DDX10	4
10595	ERN2	3
1643	DDB2	1
2072	ERCC4	1
5588	PRKCQ	1
4297	KMT2A	3
7385	UQCRC2	1
51151	SLC45A2	5
7248	TSC1	3
4619	MYH1	2
332	BIRC5	1
57680	CHD8	2
2067	ERCC1	1
2041	EPHA1	5
8031	NCOA4	6
10111	RAD50	2
9223	MAGI1	3
1789	DNMT3B	1
140913	PPIAP10	3
53353	LRP1B	7
3181	HNRNPA2B1	3
9659	PDE4DIP	5
4000	LMNA	3
54101	RIPK4	3
283455	KSR2	2
3557	IL1RN	3
2130	EWSR1	2
131890	GRK7	4
1385	CREB1	3
5587	PRKD1	1
5583	PRKCH	2
10734	STAG3	7
2321	FLT1	4
57448	BIRC6	2
8317	CDC7	2
23139	MAST2	4
22982	DIP2C	4
2157	F8	3
7227	TRPS1	4
53335	BCL11A	3
5506	PPP1R3A	5
3709	ITPR2	2
57147	SCYL3	5
6778	STAT6	6
8899	PRPF4B	5
23301	EHBP1	2
5603	MAPK13	6
3984	LIMK1	2
8428	STK24	1
4772	NFATC1	1
6777	STAT5B	1
3552	IL1A	1
80216	ALPK1	2
201163	FLCN	6
4261	CIITA	3
84072	HORMAD1	2
170685	NUDT10	1
444	ASPH	3
11076	TPPP	4
80781	COL18A1	3
7913	DEK	3
2122	MECOM	3
51167	CYB5R4	1
1760	DMPK	2
5087	PBX1	3
3815	KIT	3
9894	TELO2	3
2903	GRIN2A	2
5925	RB1	2
4217	MAP3K5	5
1209	CLPTM1	2
2074	ERCC6	3
3131	HLF	6
862	RUNX1T1	2
3691	ITGB4	2
10420	TESK2	1
7403	KDM6A	3
2308	FOXO1	3
7508	XPC	5
112268437	LOC112268437	3
8841	HDAC3	1
4302	MLLT6	3
4638	MYLK	2
51364	ZMYND10	3
197259	MLKL	6
55959	SULF2	1
9878	TOX4	5
3716	JAK1	3
171017	ZNF384	6
3488	IGFBP5	1
23092	ARHGAP26	1
4299	AFF1	3
142	PARP1	4
139604	MAGEB16	3
2073	ERCC5	2
84197	POMK	5
4040	LRP6	1
84446	BRSK1	3
55422	ZNF331	4
581	BAX	4
3092	HIP1	1
79966	SCD5	3
8321	FZD1	3
156	GRK2	3
4763	NF1	1
1612	DAPK1	3
5260	PHKG1	4
55791	LRIF1	5
9625	AATK	2
4613	MYCN	6
4591	TRIM37	3
57096	RPGRIP1	1
2044	EPHA5	5
5287	PIK3C2B	5
30811	HUNK	4
23683	PRKD3	3
3679	ITGA7	5
1608	DGKG	2
4193	MDM2	1
7294	TXK	2
4738	NEDD8	3
29110	TBK1	5
1499	CTNNB1	5
2444	FRK	2
56155	TEX14	2
1436	CSF1R	3
2886	GRB7	3
1795	DOCK3	2
11035	RIPK3	3
5624	PROC	1
5970	RELA	2

Gene in drug-gene network: Network Plot

Models in nutlin 3

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.