BIRC5
Summary: This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| baculoviral IAP repeat containing 5 | MIM:603352 | Ensembl:ENSG00000089685 | HGNC:HGNC:593 | PA25362 | 17q25.3 |
GO terms in BIRC5
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IEA | GO:0007059 | chromosome segregation |
| BP | IEP | GO:0007605 | sensory perception of sound |
| BP | TAS | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IMP | GO:0031503 | protein-containing complex localization |
| BP | TAS | GO:0042981 | regulation of apoptotic process |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IEA | GO:0051301 | cell division |
| BP | IBA | GO:0090307 | mitotic spindle assembly |
| CC | IDA | GO:0000228 | nuclear chromosome |
| CC | IDA | GO:0000775 | chromosome, centromeric region |
| CC | IDA | GO:0000777 | condensed chromosome kinetochore |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005819 | spindle |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005874 | microtubule |
| CC | IDA | GO:0030496 | midbody |
| CC | IPI | GO:0032133 | chromosome passenger complex |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008017 | microtubule binding |
| MF | IPI | GO:0008536 | Ran GTPase binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IPI | GO:0051087 | chaperone binding |
Gene expression in normal tissue: BIRC5
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BIRC5
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-141424 | Amplification of signal from the kinetochores |
| reactome | R-HSA-141444 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2467813 | Separation of Sister Chromatids |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2555396 | Mitotic Metaphase and Anaphase |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-4615885 | SUMOylation of DNA replication proteins |
| reactome | R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-6803205 | TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68882 | Mitotic Anaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69618 | Mitotic Spindle Checkpoint |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8951664 | Neddylation |
| biocarta | bcellsurvivalpathway | b cell survival pathway |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04215 | Apoptosis - multiple species - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| pid | aurora_a_pathway | Aurora A signaling |
| pid | aurora_b_pathway | Aurora B signaling |
| pid | foxm1pathway | FOXM1 transcription factor network |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP2332 | Interleukin-11 Signaling Pathway |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP2864 | Apoptosis-related network due to altered Notch3 in ovarian cancer |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP3614 | Photodynamic therapy-induced HIF-1 survival signaling |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP3802 | TP53 Regulates Transcription of Cell Death Genes |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD1020 | Trastuzumab | 1 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD62 | Platinum | 1 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD331 | Taxane | 1 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD322 | FK 866 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BIRC5
CLASSFICATION
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