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iGMDRD398

Canonical SMILES: CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4

InChI: InChI=1S/C20H19N4O3/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25/h3-8,11H,9-10,12H2,1-2H3/q+1

InChI Key: OTSOOHRUMBRSHZ-UHFFFAOYSA-N

Standard Name	Pubchem CID	Drug Status	Drug Type
Sepantronium	10126200	Alone	Small Molecule

Drug Targets:

BIRC5 (Survivin)

Drug Pathways:

Apoptosis regulation

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
64901	RANBP17	3
1147	CHUK	1
9833	MELK	1
4854	NOTCH3	3
7514	XPO1	1
7074	TIAM1	2
3725	JUN	3
10903	MTMR11	2
7535	ZAP70	1
79054	TRPM8	3
10221	TRIB1	3
3383	ICAM1	3
8915	BCL10	2
8476	CDC42BPA	3
7161	TP73	3
11183	MAP4K5	2
29101	SSU72	3
4291	MLF1	3
8929	PHOX2B	3
2200	FBN1	4
7171	TPM4	3
3708	ITPR1	1
1588	CYP19A1	2
1520	CTSS	3
93	ACVR2B	3
4750	NEK1	3
2100	ESR2	2
8266	UBL4A	2
5934	RBL2	3
57143	ADCK1	6
2335	FN1	3
4928	NUP98	6
53616	ADAM22	2
6938	TCF12	3
7850	IL1R2	3
9475	ROCK2	3
83942	TSSK1B	2
2176	FANCC	3
5241	PGR	3
5133	PDCD1	2
29888	STRN4	3
5079	PAX5	4
64783	RBM15	4
10863	ADAM28	2
1136	CHRNA3	3
23213	SULF1	3
22853	LMTK2	6
23310	NCAPD3	2
6318	SERPINB4	2
4092	SMAD7	3
84299	MIEN1	2
7048	TGFBR2	2
112858	TP53RK	2
1893	ECM1	2
5756	TWF1	2
2043	EPHA4	2
2313	FLI1	3
56164	STK31	2
2984	GUCY2C	4
9048	ARTN	2
5966	REL	2
9411	ARHGAP29	2
5074	PAWR	3
85021	REPS1	2
3604	TNFRSF9	2
29998	BICRA	2
10438	C1D	3
27148	STK36	1
5396	PRRX1	3
55351	STK32B	5
7173	TPO	2
139378	ADGRG4	2
7158	TP53BP1	5
89910	UBE3B	2
4001	LMNB1	3
9578	CDC42BPB	2
23522	KAT6B	2
55728	N4BP2	3
10006	ABI1	3
102	ADAM10	2
55819	RNF130	3
5900	RALGDS	3
11073	TOPBP1	2
7025	NR2F1	3
2051	EPHB6	4
608	TNFRSF17	3
4478	MSN	3
8549	LGR5	6
22806	IKZF3	2
166614	DCLK2	2
7416	VDAC1	3
3645	INSRR	2
8313	AXIN2	3
6733	SRPK2	2
6091	ROBO1	2
2042	EPHA3	3
29904	EEF2K	3
51804	SIX4	3
4194	MDM4	2
269	AMHR2	2
83931	STK40	2
55681	SCYL2	2
238	ALK	2
171019	ADAMTS19	2
983	CDK1	1
85443	DCLK3	4
6850	SYK	1
54899	PXK	2
23191	CYFIP1	3
5127	CDK16	3
9759	HDAC4	1
25989	ULK3	3
8215	DVL1P1	2
10087	COL4A3BP	3
5591	PRKDC	3
8859	STK19	2
80312	TET1	3
659	BMPR2	2
9472	AKAP6	1
8515	ITGA10	2
2778	GNAS	2
3667	IRS1	2
80243	PREX2	3
472	ATM	2
2734	GLG1	3
54986	ULK4	2
5289	PIK3C3	1
898	CCNE1	1
23152	CIC	2
7681	MKRN3	3
56648	EIF5A2	3
10062	NR1H3	3
5108	PCM1	2
9794	MAML1	2
8576	STK16	3
9874	TLK1	1
11143	KAT7	3
27347	STK39	2
7157	TP53	1
6794	STK11	1
7869	SEMA3B	2
6184	RPN1	4
2133	EXT3	3
1045	CDX2	2
8833	GMPS	3
344387	CDKL4	3
8874	ARHGEF7	8
5597	MAPK6	6
10516	FBLN5	2
136332	LRGUK	2
652	BMP4	2
1656	DDX6	3
5650	KLK7	3
8115	TCL1A	3
6103	RPGR	1
4437	MSH3	3
23269	MGA	4
7994	KAT6A	1
57551	TAOK1	5
4089	SMAD4	4
54658	UGT1A1	1
6654	SOS1	8
672	BRCA1	2
2737	GLI3	2
7204	TRIO	1
256536	TCERG1L	3
9252	RPS6KA5	2
139760	GPR119	3
78989	COLEC11	2
23373	CRTC1	2
5727	PTCH1	2
9448	MAP4K4	2
285220	EPHA6	2
51366	UBR5	6
23678	SGK3	5
85414	SLC45A3	3
2047	EPHB1	2
7786	MAP3K12	2
57144	PAK5	4
286133	SCARA5	3
440275	EIF2AK4	2
5290	PIK3CA	1
1514	CTSL	4
90	ACVR1	3
7043	TGFB3	3
2318	FLNC	2
10565	ARFGEF1	2
5530	PPP3CA	2
3458	IFNG	2
26166	RGS22	3
28958	COA3	3
1956	EGFR	2
157680	VPS13B	2
64333	ARHGAP9	2
5599	MAPK8	5
1459	CSNK2A2	2
8013	NR4A3	6
90427	BMF	2
100130933	SMIM6	3
5462	POU5F1B	2
1440	CSF3	2
51265	CDKL3	3
51701	NLK	3
2189	FANCG	3
7443	VRK1	2
1653	DDX1	3
8900	CCNA1	2
5187	PER1	3
7917	BAG6	3
375056	MIA3	3
91754	NEK9	1
3949	LDLR	3
57082	KNL1	2
4790	NFKB1	3
1769	DNAH8	2
4863	NPAT	3
780	DDR1	3
57538	ALPK3	1
2078	ERG	3
339345	NANOS2	2
120892	LRRK2	1
65268	WNK2	2
867	CBL	4
1677	DFFB	3
84441	MAML2	2
7301	TYRO3	1
8178	ELL	1
10253	SPRY2	3
5378	PMS1	5
9451	EIF2AK3	2
7286	TUFT1	3
4853	NOTCH2	4
9509	ADAMTS2	2
266747	RGL4	2
8312	AXIN1	2
208	AKT2	5
2796	GNRH1	3
80124	VCPIP1	2
4914	NTRK1	2
667	DST	2
83666	PARP9	2
2897	GRIK1	2
6770	STAR	3
1950	EGF	2
177	AGER	3
995	CDC25C	3
7059	THBS3	3
55359	STYK1	3
6787	NEK4	2
29959	NRBP1	3
53904	MYO3A	2
387	RHOA	2
55561	CDC42BPG	3
128869	PIGU	2
10243	GPHN	3
221895	JAZF1	2
8805	TRIM24	2
10595	ERN2	6
2072	ERCC4	4
5588	PRKCQ	2
1493	CTLA4	3
10076	PTPRU	2
558	AXL	2
332	BIRC5	2
3297	HSF1	3
2690	GHR	4
2041	EPHA1	2
8031	NCOA4	3
5395	PMS2	4
860	RUNX2	5
1789	DNMT3B	2
140913	PPIAP10	3
5609	MAP2K7	2
9659	PDE4DIP	2
9201	DCLK1	2
4000	LMNA	4
54101	RIPK4	2
6093	ROCK1	5
3624	INHBA	5
598	BCL2L1	1
5587	PRKD1	1
900	CCNG1	3
2321	FLT1	2
6196	RPS6KA2	6
5681	PSKH1	6
22982	DIP2C	4
7227	TRPS1	4
5506	PPP1R3A	4
8899	PRPF4B	5
51562	MBIP	3
6777	STAT5B	2
3552	IL1A	2
80216	ALPK1	1
5915	RARB	3
330	BIRC3	3
4330	MN1	3
170685	NUDT10	3
11076	TPPP	2
23250	ATP11A	3
7913	DEK	3
51167	CYB5R4	3
1760	DMPK	3
2065	ERBB3	1
5324	PLAG1	3
3691	ITGB4	2
1432	MAPK14	6
4615	MYD88	3
8841	HDAC3	4
197259	MLKL	7
255239	ANKK1	2
55959	SULF2	2
171017	ZNF384	3
2011	MARK2	2
23092	ARHGAP26	4
9262	STK17B	6
2261	FGFR3	2
139604	MAGEB16	3
79577	CDC73	4
84197	POMK	2
1013	CDH15	3
581	BAX	3
3092	HIP1	3
57697	FANCM	3
440270	GOLGA8B	5
2044	EPHA5	2
4593	MUSK	2
23683	PRKD3	3
699	BUB1	2
4193	MDM2	2
6868	ADAM17	1
2444	FRK	5
27151	CPAMD8	2
1436	CSF1R	3
2886	GRB7	3
2904	GRIN2B	2
5624	PROC	5
1488	CTBP2	2

Gene in drug-gene network: Network Plot

Models in Sepantronium

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.