AXIN2


Summary: The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
axin 2MIM:604025Ensembl:ENSG00000168646HGNC:HGNC:904PA2519617q24.1

GO terms in AXIN2


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001756somitogenesis
BPIMPGO:0001934positive regulation of protein phosphorylation
BPIEAGO:0003139secondary heart field specification
BPIEAGO:0003413chondrocyte differentiation involved in endochondral bone morphogenesis
BPIEAGO:0008283cell proliferation
BPIMPGO:0008285negative regulation of cell proliferation
BPIMPGO:0010718positive regulation of epithelial to mesenchymal transition
BPIMPGO:0010942positive regulation of cell death
BPIEAGO:0016055Wnt signaling pathway
BPIEAGO:0030282bone mineralization
BPIMPGO:0032423regulation of mismatch repair
BPIDAGO:0034613cellular protein localization
BPIMPGO:0042476odontogenesis
BPIEAGO:0043547positive regulation of GTPase activity
BPIMPGO:0043570maintenance of DNA repeat elements
BPIMPGO:0048255mRNA stabilization
BPIEAGO:0061181regulation of chondrocyte development
BPIMPGO:0070602regulation of centromeric sister chromatid cohesion
BPIDAGO:0090090negative regulation of canonical Wnt signaling pathway
BPIMPGO:0090090negative regulation of canonical Wnt signaling pathway
BPTASGO:0090263positive regulation of canonical Wnt signaling pathway
BPTASGO:1904837beta-catenin-TCF complex assembly
CCIDAGO:0005634nucleus
CCIDAGO:0005737cytoplasm
CCIDAGO:0005813centrosome
CCTASGO:0005829cytosol
CCNASGO:0030877beta-catenin destruction complex
MFIPIGO:0005515protein binding
MFNASGO:0008013beta-catenin binding
MFIPIGO:0019899enzyme binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIEAGO:0070411I-SMAD binding

Gene expression in normal tissue: AXIN2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AXIN2


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201722Formation of the beta-catenin:TCF transactivating complex
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-4411364Binding of TCF/LEF:CTNNB1 to target gene promoters
reactomeR-HSA-4641257Degradation of AXIN
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-597592Post-translational protein modification
pidbetacatenin_deg_pathwayDegradation of beta catenin
pidbetacatenin_nuc_pathwayRegulation of nuclear beta catenin signaling and target gene transcription
pidera_genomic_pathwayValidated nuclear estrogen receptor alpha network
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05217Basal cell carcinoma - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
wikipathwaysWP2064Neural Crest Differentiation
wikipathwaysWP2773Degradation of beta-catenin by the destruction complex
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP3339TCF dependent signaling in response to WNT
wikipathwaysWP3558Beta-catenin independent WNT signaling
wikipathwaysWP363Wnt Signaling Pathway
wikipathwaysWP3658Wnt-beta-catenin Signaling Pathway in Leukemia
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4216Chromosomal and microsatellite instability in colorectal cancer

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD634SCHEMBL26080417
iGMDRD280CYTOCHALASIN B1
iGMDRD679Bistramide A1
iGMDRD297Austocystin D2
iGMDRD193Fqi11
iGMDRD446LY 21832403
iGMDRD781Sirolimus5
iGMDRD494Neopeltolide1
iGMDRD779PRL-3 Inhibitor I3
iGMDRD144NSC953976
iGMDRD670ML 2104
iGMDRD1008SR-II-138A3
iGMDRD772BRD47706
iGMDRD599Salermide4
iGMDRD126Tipifarnib4
iGMDRD524ISX-93
iGMDRD356PNU-746544
iGMDRD369TGX-1152
iGMDRD398Sepantronium3
iGMDRD506Fedratinib3
iGMDRD399Selumetinib2
iGMDRD74Idarubicin3
iGMDRD188Piperlongumine5
iGMDRD100Zebularine3
iGMDRD294Batimastat3
iGMDRD318PAC-12
iGMDRD171Pemetrexed2
iGMDRD474Avrainvillamide3
iGMDRD138PX 123
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD945ML2142
iGMDRD154NSC237662
iGMDRD123Isoevodiamine2
iGMDRD177Teniposide4
iGMDRD211(1S,3R)-RSL34
iGMDRD499PDMP3
iGMDRD351GW843682X3
iGMDRD698Neratinib4
iGMDRD150RITA8
iGMDRD116CD4372
iGMDRD512nutlin 37
iGMDRD307Manumycin A3
iGMDRD84Lovastatin acid1
iGMDRD82Quiflapon3
iGMDRD42Vorinostat3
iGMDRD246NPC263
iGMDRD300Tozasertib3
iGMDRD329Merck607
iGMDRD872BRD71376
iGMDRD871BRD63683
iGMDRD286Nsc 6328393
iGMDRD267Oligomycin A2
iGMDRD415LE-1351
iGMDRD289Parthenolide3
iGMDRD221Tamoxifen3
iGMDRD705Nakiterpiosin2
iGMDRD5Tyrphostin AG 14786
iGMDRD271Brefeldin A3
iGMDRD158NSC1415404
iGMDRD202Curcumin3
iGMDRD103SN-383

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AXIN2

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