AXIN2
Summary: The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nameaxin 2 OMIM IDMIM:604025 Ensembl IDEnsembl:ENSG00000168646 HGNC IDHGNC:HGNC:904 PHARMGKB IDPA25196 Map Location17q24.1 | |||||
GO terms in AXIN2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001756 | somitogenesis |
| BP | IMP | GO:0001934 | positive regulation of protein phosphorylation |
| BP | IEA | GO:0003139 | secondary heart field specification |
| BP | IEA | GO:0003413 | chondrocyte differentiation involved in endochondral bone morphogenesis |
| BP | IEA | GO:0008283 | cell proliferation |
| BP | IMP | GO:0008285 | negative regulation of cell proliferation |
Gene expression in normal tissue: AXIN2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AXIN2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4411364 | Binding of TCF/LEF:CTNNB1 to target gene promoters |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AXIN2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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