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iGMDRD5

Canonical SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC

InChI: InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)

InChI Key: GFNNBHLJANVSQV-UHFFFAOYSA-N

Standard Name	Pubchem CID	Drug Status	Drug Type
Tyrphostin AG-1478	2051	Alone	Small Molecule

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
331	XIAP	2
3696	ITGB8	1
27102	EIF2AK1	2
1105	CHD1	2
7074	TIAM1	4
79848	CSPP1	2
7128	TNFAIP3	2
21	ABCA3	3
6195	RPS6KA1	3
114801	TMEM200A	2
3708	ITPR1	3
9706	ULK2	4
7272	TTK	3
3845	KRAS	2
23097	CDK19	3
55215	FANCI	1
8289	ARID1A	5
701	BUB1B	3
3939	LDHA	5
79092	CARD14	3
83942	TSSK1B	2
9869	SETDB1	2
7764	ZNF217	5
5133	PDCD1	2
79820	CATSPERB	3
390502	SERPINA2	5
5754	PTK7	2
56776	FMN2	2
51684	SUFU	3
10892	MALT1	1
10863	ADAM28	3
4170	MCL1	3
1607	DGKB	3
3694	ITGB6	6
10142	AKAP9	3
22853	LMTK2	3
7253	TSHR	7
23310	NCAPD3	2
7098	TLR3	3
3195	TLX1	3
5298	PI4KB	3
2241	FER	2
1404	HAPLN1	3
2623	GATA1	3
140469	MYO3B	5
54822	TRPM7	6
577	ADGRB3	3
80122	MAP3K19	2
1387	CREBBP	2
55023	PHIP	3
4283	CXCL9	3
7133	TNFRSF1B	2
79858	NEK11	2
9048	ARTN	5
3055	HCK	1
2977	GUCY1A2	3
10438	C1D	2
5166	PDK4	3
4851	NOTCH1	2
139378	ADGRG4	3
55294	FBXW7	3
6927	HNF1A	2
8030	CCDC6	1
11073	TOPBP1	5
7025	NR2F1	6
23012	STK38L	1
4478	MSN	3
3556	IL1RAP	1
8396	PIP4K2B	3
3645	INSRR	3
200576	PIKFYVE	2
8313	AXIN2	6
6091	ROBO1	2
2042	EPHA3	3
23255	MTCL1	2
80129	CCDC170	3
10188	TNK2	2
11169	WDHD1	3
51804	SIX4	3
269	AMHR2	2
55681	SCYL2	2
2045	EPHA7	4
375449	MAST4	1
287015	TRIM42	2
8643	PTCH2	3
9759	HDAC4	2
64170	CARD9	3
219970	GLYATL2	3
8215	DVL1P1	3
6793	STK10	1
8859	STK19	3
79705	LRRK1	3
6464	SHC1	7
7507	XPA	3
2778	GNAS	3
3685	ITGAV	2
472	ATM	2
5924	RASGRF2	1
4087	SMAD2	3
84433	CARD11	3
5450	POU2AF1	3
5327	PLAT	1
9319	TRIP13	3
1029	CDKN2A	1
23048	FNBP1	3
27436	EML4	1
9874	TLK1	3
11143	KAT7	3
7157	TP53	2
7704	ZBTB16	2
4855	NOTCH4	1
57194	ATP10A	2
4857	NOVA1	1
25836	NIPBL	3
3791	KDR	3
1019	CDK4	1
85481	PSKH2	3
5604	MAP2K1	6
55034	MOCOS	3
5597	MAPK6	2
10516	FBLN5	3
6197	RPS6KA3	1
57188	ADAMTSL3	2
55589	BMP2K	4
65125	WNK1	5
136332	LRGUK	5
652	BMP4	2
7175	TPR	6
80205	CHD9	2
57578	UNC79	4
2071	ERCC3	1
57551	TAOK1	2
4089	SMAD4	1
51284	TLR7	3
6654	SOS1	1
78989	COLEC11	1
23373	CRTC1	3
285220	EPHA6	1
51366	UBR5	3
85414	SLC45A3	3
5297	PI4KA	2
4214	MAP3K1	1
2187	FANCB	1
84823	LMNB2	3
5290	PIK3CA	6
1514	CTSL	4
1000	CDH2	2
5366	PMAIP1	1
7043	TGFB3	1
2318	FLNC	3
1956	EGFR	7
4318	MMP9	3
64333	ARHGAP9	3
11064	CNTRL	4
64750	SMURF2	5
1459	CSNK2A2	6
8013	NR4A3	3
1440	CSF3	1
6446	SGK1	1
3553	IL1B	2
5747	PTK2	3
5156	PDGFRA	3
7443	VRK1	2
91754	NEK9	3
27330	RPS6KA6	2
203102	ADAM32	5
57082	KNL1	1
57538	ALPK3	3
120892	LRRK2	2
89795	NAV3	2
65268	WNK2	3
867	CBL	6
6095	RORA	3
5205	ATP8B1	3
11184	MAP4K1	3
23118	TAB2	3
5979	RET	3
5378	PMS1	2
8491	MAP4K3	3
9509	ADAMTS2	4
23049	SMG1	3
57521	RPTOR	3
3554	IL1R1	3
140803	TRPM6	3
177	AGER	1
1676	DFFA	3
7042	TGFB2	3
5582	PRKCG	4
7465	WEE1	1
6787	NEK4	3
9372	ZFYVE9	1
2046	EPHA8	2
5532	PPP3CB	5
57820	CCNB1IP1	1
5291	PIK3CB	2
7248	TSC1	2
4619	MYH1	1
5562	PRKAA1	3
860	RUNX2	3
53353	LRP1B	2
5609	MAP2K7	1
9659	PDE4DIP	2
54101	RIPK4	2
6093	ROCK1	2
5927	KDM5A	4
3717	JAK2	3
3552	IL1A	1
182	JAG1	3
51167	CYB5R4	3
5087	PBX1	1
9212	AURKB	3
8661	EIF3A	3
2308	FOXO1	1
7508	XPC	1
8841	HDAC3	2
4205	MEF2A	6
3092	HIP1	2
55791	LRIF1	1
4629	MYH11	6
81788	NUAK2	6
4193	MDM2	2
27255	CNTN6	2
2444	FRK	6
5602	MAPK10	2
2892	GRIA3	3
1795	DOCK3	1

Gene in drug-gene network: Network Plot

Models in Tyrphostin AG-1478

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.