ADAM32
Summary: This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. This gene is predominantly expressed in the testis. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ADAM metallopeptidase domain 32 | Ensembl:ENSG00000197140 | HGNC:HGNC:15479 | PA134932610 | 8p11.22 |
GO terms in ADAM32
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0016021 | integral component of membrane |
| BP | IEA | GO:0006508 | proteolysis |
| MF | IEA | GO:0004222 | metalloendopeptidase activity |
Gene expression in normal tissue: ADAM32
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADAM32
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD871 | BRD6368 | 4 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 5 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD123 | Isoevodiamine | 6 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD511 | CHEMBL399379 | 2 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD116 | CD437 | 4 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 4 |
| iGMDRD100 | Zebularine | 6 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD64 | Parbendazole | 5 |
| iGMDRD356 | PNU-74654 | 4 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD433 | Lexibulin | 4 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD484 | Pluripotin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADAM32
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