ADAM32


Summary: This gene encodes a member of the disintegrin family of membrane-anchored proteins that play a role in diverse biological processes such as brain development, fertilization, tumor development and inflammation. This gene is predominantly expressed in the testis. The encoded protein undergoes proteolytic processing to generate a mature polypeptide comprised of an metalloprotease, disintegrin and epidermal growth factor-like domains. This gene is located in a cluster of other disintegrin and metallopeptidase family genes on chromosome 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ADAM metallopeptidase domain 32Ensembl:ENSG00000197140HGNC:HGNC:15479PA1349326108p11.22

GO terms in ADAM32


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0016021integral component of membrane
BPIEAGO:0006508proteolysis
MFIEAGO:0004222metalloendopeptidase activity

Gene expression in normal tissue: ADAM32

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ADAM32


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD286Nsc 6328393
iGMDRD871BRD63684
iGMDRD329Merck603
iGMDRD662JQ-12
iGMDRD82Quiflapon2
iGMDRD137Indisulam3
iGMDRD5Tyrphostin AG 14785
iGMDRD705Nakiterpiosin2
iGMDRD289Parthenolide3
iGMDRD434BMS-5369241
iGMDRD267Oligomycin A2
iGMDRD85Ursolic acid2
iGMDRD123Isoevodiamine6
iGMDRD177Teniposide1
iGMDRD511CHEMBL3993792
iGMDRD84Lovastatin acid3
iGMDRD248BRD43541
iGMDRD116CD4374
iGMDRD345Compound 10b [PMID: 11504634]4
iGMDRD100Zebularine6
iGMDRD888Compound 443
iGMDRD60Quinoclamine3
iGMDRD64Parbendazole5
iGMDRD356PNU-746544
iGMDRD524ISX-93
iGMDRD270Ciclosporin2
iGMDRD138PX 123
iGMDRD187BRD98761
iGMDRD446LY 21832403
iGMDRD201SKI II3
iGMDRD193Fqi14
iGMDRD433Lexibulin4
iGMDRD1008SR-II-138A2
iGMDRD546BMS-7548072
iGMDRD144NSC953972
iGMDRD483SCH-5290742
iGMDRD484Pluripotin3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ADAM32

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