iGMDRD138
| Standard Name | CHEMBL | Pubchem CID | DRUGBANK ID | Drug Status | Drug Type |
|---|---|---|---|---|---|
| PX 12 | CHEMBL406050 | 219104 | DB05448 | Alone | Small Molecule |
Drug Targets:
TXNRD1 (Q16881)Drug-model tissue-cancer distribution: Bubble Plot
Drug-gene pathway enrichments
Drug-gene GO enrichments
Drug-Gene: Aster Plot
| Gene ID | Gene Name | Model Num. |
|---|---|---|
| 331 | XIAP | 2 |
| 27102 | EIF2AK1 | 2 |
| 1105 | CHD1 | 3 |
| 27125 | AFF4 | 5 |
| 7514 | XPO1 | 1 |
| 8999 | CDKL2 | 3 |
| 7074 | TIAM1 | 1 |
| 8019 | BRD3 | 2 |
| 5027 | P2RX7 | 3 |
| 471 | ATIC | 3 |
| 79054 | TRPM8 | 3 |
| 1464 | CSPG4 | 1 |
| 7128 | TNFAIP3 | 1 |
| 6491 | STIL | 2 |
| 10987 | COPS5 | 3 |
| 6774 | STAT3 | 3 |
| 5933 | RBL1 | 3 |
| 6195 | RPS6KA1 | 3 |
| 8915 | BCL10 | 2 |
| 8476 | CDC42BPA | 2 |
| 79947 | DHDDS | 3 |
| 4627 | MYH9 | 3 |
| 2200 | FBN1 | 1 |
| 51765 | STK26 | 3 |
| 57679 | ALS2 | 3 |
| 3708 | ITPR1 | 1 |
| 57554 | LRRC7 | 2 |
| 9706 | ULK2 | 3 |
| 7272 | TTK | 3 |
| 347365 | ITIH6 | 2 |
| 4750 | NEK1 | 3 |
| 5295 | PIK3R1 | 2 |
| 80070 | ADAMTS20 | 5 |
| 8266 | UBL4A | 2 |
| 8573 | CASK | 3 |
| 2335 | FN1 | 3 |
| 4928 | NUP98 | 1 |
| 79092 | CARD14 | 3 |
| 6938 | TCF12 | 2 |
| 2475 | MTOR | 3 |
| 1263 | PLK3 | 2 |
| 3551 | IKBKB | 3 |
| 4036 | LRP2 | 2 |
| 7764 | ZNF217 | 2 |
| 11160 | ERLIN2 | 3 |
| 10395 | DLC1 | 5 |
| 5133 | PDCD1 | 1 |
| 3069 | HDLBP | 1 |
| 11116 | FGFR1OP | 5 |
| 7444 | VRK2 | 2 |
| 6657 | SOX2 | 6 |
| 390502 | SERPINA2 | 4 |
| 56776 | FMN2 | 3 |
| 64783 | RBM15 | 4 |
| 10892 | MALT1 | 4 |
| 4771 | NF2 | 3 |
| 10863 | ADAM28 | 2 |
| 3694 | ITGB6 | 3 |
| 23213 | SULF1 | 3 |
| 3066 | HDAC2 | 8 |
| 10142 | AKAP9 | 1 |
| 23310 | NCAPD3 | 2 |
| 5298 | PI4KB | 3 |
| 8749 | ADAM18 | 3 |
| 2241 | FER | 3 |
| 1404 | HAPLN1 | 2 |
| 22821 | RASA3 | 4 |
| 7048 | TGFBR2 | 6 |
| 79934 | COQ8B | 1 |
| 54822 | TRPM7 | 6 |
| 80122 | MAP3K19 | 2 |
| 1387 | CREBBP | 8 |
| 2043 | EPHA4 | 5 |
| 3727 | JUND | 3 |
| 5788 | PTPRC | 3 |
| 4283 | CXCL9 | 3 |
| 10013 | HDAC6 | 3 |
| 2984 | GUCY2C | 3 |
| 11200 | CHEK2 | 3 |
| 31 | ACACA | 3 |
| 51755 | CDK12 | 3 |
| 9048 | ARTN | 3 |
| 3604 | TNFRSF9 | 2 |
| 8295 | TRRAP | 4 |
| 10438 | C1D | 6 |
| 11122 | PTPRT | 1 |
| 10215 | OLIG2 | 3 |
| 5314 | PKHD1 | 3 |
| 139378 | ADGRG4 | 6 |
| 7158 | TP53BP1 | 2 |
| 145264 | SERPINA12 | 6 |
| 55294 | FBXW7 | 1 |
| 54567 | DLL4 | 6 |
| 55728 | N4BP2 | 4 |
| 54477 | PLEKHA5 | 5 |
| 22861 | NLRP1 | 5 |
| 440279 | UNC13C | 4 |
| 4610 | MYCL | 4 |
| 4301 | AFDN | 3 |
| 84033 | OBSCN | 5 |
| 5607 | MAP2K5 | 2 |
| 342977 | NANOS3 | 3 |
| 256646 | NUTM1 | 1 |
| 11073 | TOPBP1 | 2 |
| 7025 | NR2F1 | 3 |
| 57787 | MARK4 | 3 |
| 169436 | STKLD1 | 3 |
| 4478 | MSN | 4 |
| 1586 | CYP17A1 | 1 |
| 32 | ACACB | 1 |
| 26353 | HSPB8 | 3 |
| 2242 | FES | 1 |
| 8313 | AXIN2 | 3 |
| 6091 | ROBO1 | 6 |
| 2042 | EPHA3 | 3 |
| 2260 | FGFR1 | 3 |
| 23255 | MTCL1 | 2 |
| 730249 | ACOD1 | 3 |
| 83990 | BRIP1 | 5 |
| 4739 | NEDD9 | 3 |
| 4194 | MDM4 | 2 |
| 55681 | SCYL2 | 4 |
| 2045 | EPHA7 | 5 |
| 23405 | DICER1 | 5 |
| 238 | ALK | 4 |
| 399979 | SNX19 | 1 |
| 4752 | NEK3 | 3 |
| 287015 | TRIM42 | 3 |
| 8643 | PTCH2 | 1 |
| 65217 | PCDH15 | 5 |
| 8395 | PIP5K1B | 2 |
| 54899 | PXK | 3 |
| 286826 | LIN9 | 6 |
| 23191 | CYFIP1 | 3 |
| 783 | CACNB2 | 2 |
| 9759 | HDAC4 | 2 |
| 7525 | YES1 | 3 |
| 1452 | CSNK1A1 | 2 |
| 6709 | SPTAN1 | 3 |
| 219970 | GLYATL2 | 3 |
| 50488 | MINK1 | 3 |
| 2068 | ERCC2 | 1 |
| 5591 | PRKDC | 3 |
| 5568 | PRKACG | 3 |
| 6464 | SHC1 | 4 |
| 6098 | ROS1 | 2 |
| 2778 | GNAS | 4 |
| 6917 | TCEA1 | 3 |
| 3667 | IRS1 | 2 |
| 80243 | PREX2 | 3 |
| 472 | ATM | 2 |
| 1009 | CDH11 | 1 |
| 575 | ADGRB1 | 4 |
| 53942 | CNTN5 | 2 |
| 5924 | RASGRF2 | 3 |
| 4087 | SMAD2 | 2 |
| 2734 | GLG1 | 1 |
| 8038 | ADAM12 | 2 |
| 1123 | CHN1 | 2 |
| 2272 | FHIT | 1 |
| 10413 | YAP1 | 6 |
| 7184 | HSP90B1 | 2 |
| 157753 | TMEM74 | 4 |
| 1910 | EDNRB | 3 |
| 9874 | TLK1 | 3 |
| 27347 | STK39 | 2 |
| 3932 | LCK | 4 |
| 58508 | KMT2C | 5 |
| 2099 | ESR1 | 3 |
| 6092 | ROBO2 | 3 |
| 7704 | ZBTB16 | 2 |
| 4173 | MCM4 | 3 |
| 6714 | SRC | 1 |
| 4855 | NOTCH4 | 2 |
| 6794 | STK11 | 7 |
| 2322 | FLT3 | 1 |
| 57194 | ATP10A | 1 |
| 7869 | SEMA3B | 2 |
| 8218 | CLTCL1 | 2 |
| 3791 | KDR | 7 |
| 836 | CASP3 | 2 |
| 4292 | MLH1 | 2 |
| 93210 | PGAP3 | 3 |
| 114788 | CSMD3 | 2 |
| 6184 | RPN1 | 3 |
| 2263 | FGFR2 | 4 |
| 1019 | CDK4 | 1 |
| 11213 | IRAK3 | 3 |
| 85481 | PSKH2 | 6 |
| 8833 | GMPS | 3 |
| 55034 | MOCOS | 3 |
| 5597 | MAPK6 | 1 |
| 7038 | TG | 1 |
| 4921 | DDR2 | 6 |
| 65125 | WNK1 | 2 |
| 136332 | LRGUK | 2 |
| 4436 | MSH2 | 3 |
| 50945 | TBX22 | 3 |
| 7175 | TPR | 3 |
| 5871 | MAP4K2 | 6 |
| 2081 | ERN1 | 3 |
| 84181 | CHD6 | 3 |
| 57578 | UNC79 | 2 |
| 8997 | KALRN | 6 |
| 3643 | INSR | 3 |
| 57551 | TAOK1 | 2 |
| 23469 | PHF3 | 6 |
| 4089 | SMAD4 | 1 |
| 170692 | ADAMTS18 | 3 |
| 54658 | UGT1A1 | 1 |
| 6654 | SOS1 | 2 |
| 672 | BRCA1 | 3 |
| 11168 | PSIP1 | 2 |
| 256536 | TCERG1L | 2 |
| 835 | CASP2 | 2 |
| 23373 | CRTC1 | 2 |
| 546 | ATRX | 2 |
| 51366 | UBR5 | 2 |
| 3426 | CFI | 2 |
| 85414 | SLC45A3 | 3 |
| 5297 | PI4KA | 2 |
| 5069 | PAPPA | 4 |
| 7786 | MAP3K12 | 3 |
| 10769 | PLK2 | 2 |
| 56997 | COQ8A | 6 |
| 5578 | PRKCA | 3 |
| 3702 | ITK | 7 |
| 602 | BCL3 | 3 |
| 3239 | HOXD13 | 3 |
| 5290 | PIK3CA | 3 |
| 92335 | STRADA | 3 |
| 3720 | JARID2 | 4 |
| 1514 | CTSL | 2 |
| 5034 | P4HB | 5 |
| 1687 | GSDME | 5 |
| 8202 | NCOA3 | 3 |
| 26524 | LATS2 | 1 |
| 85366 | MYLK2 | 3 |
| 2318 | FLNC | 5 |
| 10565 | ARFGEF1 | 5 |
| 64919 | BCL11B | 3 |
| 675 | BRCA2 | 5 |
| 3458 | IFNG | 3 |
| 26166 | RGS22 | 2 |
| 7075 | TIE1 | 3 |
| 1956 | EGFR | 3 |
| 640 | BLK | 2 |
| 2735 | GLI1 | 2 |
| 4609 | MYC | 1 |
| 64333 | ARHGAP9 | 3 |
| 11064 | CNTRL | 2 |
| 64750 | SMURF2 | 2 |
| 5789 | PTPRD | 2 |
| 5599 | MAPK8 | 1 |
| 8021 | NUP214 | 2 |
| 1459 | CSNK2A2 | 3 |
| 8013 | NR4A3 | 3 |
| 10461 | MERTK | 8 |
| 26278 | SACS | 3 |
| 5462 | POU5F1B | 1 |
| 51265 | CDKL3 | 2 |
| 51701 | NLK | 2 |
| 6446 | SGK1 | 3 |
| 3553 | IL1B | 2 |
| 5747 | PTK2 | 3 |
| 7443 | VRK1 | 2 |
| 3635 | INPP5D | 2 |
| 91754 | NEK9 | 6 |
| 93627 | TBCK | 4 |
| 6872 | TAF1 | 2 |
| 203102 | ADAM32 | 3 |
| 673 | BRAF | 1 |
| 7153 | TOP2A | 3 |
| 57082 | KNL1 | 1 |
| 84630 | TTBK1 | 5 |
| 1981 | EIF4G1 | 4 |
| 4790 | NFKB1 | 3 |
| 84879 | MFSD2A | 5 |
| 22976 | PAXIP1 | 2 |
| 23532 | PRAME | 3 |
| 4863 | NPAT | 3 |
| 780 | DDR1 | 2 |
| 83452 | RAB33B | 1 |
| 57538 | ALPK3 | 1 |
| 8924 | HERC2 | 1 |
| 120892 | LRRK2 | 4 |
| 89795 | NAV3 | 6 |
| 65268 | WNK2 | 3 |
| 867 | CBL | 3 |
| 6095 | RORA | 2 |
| 7301 | TYRO3 | 1 |
| 7468 | NSD2 | 5 |
| 11184 | MAP4K1 | 3 |
| 8178 | ELL | 3 |
| 9064 | MAP3K6 | 3 |
| 5979 | RET | 3 |
| 9451 | EIF2AK3 | 4 |
| 11262 | SP140 | 5 |
| 5563 | PRKAA2 | 3 |
| 23742 | NPAP1 | 3 |
| 8312 | AXIN1 | 5 |
| 55521 | TRIM36 | 6 |
| 10752 | CHL1 | 3 |
| 208 | AKT2 | 3 |
| 51330 | TNFRSF12A | 3 |
| 22883 | CLSTN1 | 2 |
| 667 | DST | 6 |
| 5305 | PIP4K2A | 3 |
| 2897 | GRIK1 | 3 |
| 6770 | STAR | 2 |
| 1950 | EGF | 2 |
| 8301 | PICALM | 3 |
| 7273 | TTN | 4 |
| 5582 | PRKCG | 5 |
| 7059 | THBS3 | 3 |
| 85415 | RHPN2 | 2 |
| 23389 | MED13L | 2 |
| 8667 | EIF3H | 3 |
| 53904 | MYO3A | 3 |
| 29941 | PKN3 | 3 |
| 54861 | SNRK | 2 |
| 55561 | CDC42BPG | 3 |
| 10249 | GLYAT | 2 |
| 7150 | TOP1 | 3 |
| 5532 | PPP3CB | 2 |
| 286151 | FBXO43 | 2 |
| 26686 | OR4E2 | 3 |
| 344905 | ATP13A5 | 4 |
| 51151 | SLC45A2 | 4 |
| 5291 | PIK3CB | 2 |
| 558 | AXL | 3 |
| 7248 | TSC1 | 4 |
| 9748 | SLK | 3 |
| 5562 | PRKAA1 | 3 |
| 317 | APAF1 | 3 |
| 2317 | FLNB | 5 |
| 10111 | RAD50 | 3 |
| 5395 | PMS2 | 1 |
| 778 | CACNA1F | 4 |
| 53353 | LRP1B | 1 |
| 55289 | ACOXL | 6 |
| 1281 | COL3A1 | 5 |
| 9659 | PDE4DIP | 6 |
| 6760 | SS18 | 3 |
| 2194 | FASN | 1 |
| 5927 | KDM5A | 7 |
| 5587 | PRKD1 | 3 |
| 57448 | BIRC6 | 4 |
| 2131 | EXT1 | 3 |
| 3717 | JAK2 | 3 |
| 22982 | DIP2C | 2 |
| 7099 | TLR4 | 6 |
| 2157 | F8 | 6 |
| 3709 | ITPR2 | 2 |
| 6778 | STAT6 | 3 |
| 4221 | MEN1 | 3 |
| 8899 | PRPF4B | 3 |
| 150094 | SIK1 | 3 |
| 51562 | MBIP | 1 |
| 6777 | STAT5B | 3 |
| 3977 | LIFR | 2 |
| 3656 | IRAK2 | 3 |
| 2122 | MECOM | 3 |
| 5087 | PBX1 | 1 |
| 3815 | KIT | 6 |
| 9212 | AURKB | 6 |
| 5054 | SERPINE1 | 1 |
| 9894 | TELO2 | 3 |
| 4974 | OMG | 3 |
| 5925 | RB1 | 2 |
| 2074 | ERCC6 | 1 |
| 8661 | EIF3A | 3 |
| 4638 | MYLK | 4 |
| 5586 | PKN2 | 3 |
| 4205 | MEF2A | 3 |
| 7040 | TGFB1 | 6 |
| 9878 | TOX4 | 3 |
| 10494 | STK25 | 3 |
| 84446 | BRSK1 | 2 |
| 55422 | ZNF331 | 4 |
| 4763 | NF1 | 4 |
| 63893 | UBE2O | 1 |
| 10891 | PPARGC1A | 2 |
| 5288 | PIK3C2G | 2 |
| 57096 | RPGRIP1 | 3 |
| 4593 | MUSK | 3 |
| 30811 | HUNK | 1 |
| 699 | BUB1 | 3 |
| 2178 | FANCE | 3 |
| 27255 | CNTN6 | 1 |
| 2444 | FRK | 3 |
| 27151 | CPAMD8 | 2 |
| 3440 | IFNA2 | 1 |
| 2892 | GRIA3 | 2 |
| 4916 | NTRK3 | 7 |
| 4486 | MST1R | 6 |
| 1488 | CTBP2 | 4 |
Gene in drug-gene network: Network Plot
Models in PX 12
CLASSFICATION
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