CASP2
Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| caspase 2 | MIM:600639 | Ensembl:ENSG00000106144 | HGNC:HGNC:1503 | PA26086 | 7q34 |
GO terms in CASP2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001554 | luteolysis |
| BP | IEA | GO:0003407 | neural retina development |
| BP | IBA | GO:0006915 | apoptotic process |
| BP | NAS | GO:0006915 | apoptotic process |
| BP | IMP | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| BP | IEA | GO:0007420 | brain development |
| BP | IEA | GO:0007568 | aging |
| BP | TAS | GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage |
| BP | IDA | GO:0016485 | protein processing |
| BP | IEA | GO:0035234 | ectopic germ cell programmed cell death |
| BP | TAS | GO:0042981 | regulation of apoptotic process |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | NAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0043525 | positive regulation of neuron apoptotic process |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
| BP | TAS | GO:0097190 | apoptotic signaling pathway |
| BP | IBA | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| BP | IEA | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| BP | TAS | GO:0097194 | execution phase of apoptosis |
| BP | IEA | GO:2001235 | positive regulation of apoptotic signaling pathway |
| CC | TAS | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0016020 | membrane |
| MF | IDA | GO:0004197 | cysteine-type endopeptidase activity |
| MF | NAS | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0019899 | enzyme binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IBA | GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process |
Gene expression in normal tissue: CASP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CASP2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP2371 | Parkinsons Disease Pathway |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP384 | Apoptosis Modulation by HSP70 |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| pid | p73pathway | p73 transcription factor network |
| netpath | Pathway_TNFalpha | TNFalpha |
| biocarta | caspasepathway | caspase cascade in apoptosis |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | irespathway | internal ribosome entry pathway |
| biocarta | stresspathway | tnf/stress related signaling |
| biocarta | tnfr1pathway | tnfr1 signaling pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168638 | NOD1/2 Signaling Pathway |
| reactome | R-HSA-168643 | Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
| reactome | R-HSA-205025 | NADE modulates death signalling |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5633008 | TP53 Regulates Transcription of Cell Death Genes |
| reactome | R-HSA-6803207 | TP53 Regulates Transcription of Caspase Activators and Caspases |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD577 | BIX01294 | 1 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD137 | Indisulam | 8 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD226 | ML006 | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD433 | Lexibulin | 1 |
| iGMDRD420 | Leucascandrolide A | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CASP2
CLASSFICATION
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