CASP2
Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
Namecaspase 2 OMIM IDMIM:600639 Ensembl IDEnsembl:ENSG00000106144 HGNC IDHGNC:HGNC:1503 PHARMGKB IDPA26086 Map Location7q34 |
GO terms in CASP2
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IEA | GO:0001554 | luteolysis |
BP | IEA | GO:0003407 | neural retina development |
BP | IBA | GO:0006915 | apoptotic process |
BP | NAS | GO:0006915 | apoptotic process |
BP | IMP | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
BP | IEA | GO:0007420 | brain development |
Gene expression in normal tissue: CASP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CASP2
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Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP1772 | Apoptosis Modulation and Signaling |
wikipathways | WP2371 | Parkinsons Disease Pathway |
wikipathways | WP254 | Apoptosis |
wikipathways | WP3639 | Apoptotic Signaling Pathway |
wikipathways | WP384 | Apoptosis Modulation by HSP70 |
kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in CASP2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |