CASP2

Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecaspase 2
OMIM IDMIM:600639
Ensembl IDEnsembl:ENSG00000106144
HGNC IDHGNC:HGNC:1503
PHARMGKB IDPA26086
Map Location7q34

GO terms in CASP2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0001554 luteolysis
BP IEA GO:0003407 neural retina development
BP IBA GO:0006915 apoptotic process
BP NAS GO:0006915 apoptotic process
BP IMP GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
BP IEA GO:0007420 brain development
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Gene expression in normal tissue: CASP2

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 25undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 2LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 3BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 7

Gene-drug pathway distribution

undefined13Apoptosis regulation1Leukocyte transendothelial migration1ERK MAPK signaling1

Pathways in CASP2


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Database
Pathway ID
Pathway Des.
wikipathways WP1772 Apoptosis Modulation and Signaling
wikipathways WP2371 Parkinsons Disease Pathway
wikipathways WP254 Apoptosis
wikipathways WP3639 Apoptotic Signaling Pathway
wikipathways WP384 Apoptosis Modulation by HSP70
kegg hsa04210 Apoptosis - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD399 Selumetinib 3
iGMDRD329 Merck60 1
iGMDRD577 BIX01294 1
iGMDRD138 PX 12 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CASP2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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