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iGMDRD154

Canonical SMILES: CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(C=C2)N=C(C=C3N)C)C

InChI: InChI=1S/C24H35N7/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30)

InChI Key: DEFBCZWQLILOJF-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	Drug Status	Drug Type
NSC23766	CHEMBL257119 CHEMBL1535331 CHEMBL3113208	409805	Alone	Small Molecule

Drug Targets:

RAC1 TIAM1 TRIO

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
64901	RANBP17	4
1147	CHUK	2
4854	NOTCH3	3
8999	CDKL2	1
5027	P2RX7	2
10903	MTMR11	2
997	CDC34	3
1464	CSPG4	4
10641	NPRL2	6
7421	VDR	3
7750	ZMYM2	3
4926	NUMA1	2
11183	MAP4K5	1
2048	EPHB2	3
5546	PRCC	2
2956	MSH6	3
55872	PBK	3
3708	ITPR1	4
1520	CTSS	3
7272	TTK	2
3845	KRAS	3
3757	KCNH2	2
4750	NEK1	3
5295	PIK3R1	2
23552	CDK20	2
55215	FANCI	3
8289	ARID1A	2
6351	CCL4	6
3939	LDHA	3
2335	FN1	3
2475	MTOR	1
1263	PLK3	4
9475	ROCK2	2
3326	HSP90AB1	3
2176	FANCC	1
11160	ERLIN2	4
10395	DLC1	2
843	CASP10	1
10320	IKZF1	3
9530	BAG4	3
7444	VRK2	4
6657	SOX2	3
6598	SMARCB1	5
23213	SULF1	2
10142	AKAP9	2
22853	LMTK2	3
23310	NCAPD3	3
5298	PI4KB	3
1404	HAPLN1	4
6887	TAL2	6
7048	TGFBR2	2
114783	LMTK3	2
202374	STK32A	4
1893	ECM1	3
9232	PTTG1	6
10013	HDAC6	6
5579	PRKCB	2
11200	CHEK2	1
2625	GATA3	1
1111	CHEK1	7
2977	GUCY1A2	1
10438	C1D	5
3456	IFNB1	5
5166	PDK4	1
5605	MAP2K2	3
139378	ADGRG4	2
8784	TNFRSF18	4
5664	PSEN2	6
9578	CDC42BPB	2
23522	KAT6B	2
55728	N4BP2	1
10818	FRS2	3
102	ADAM10	1
4610	MYCL	6
3976	LIF	3
2115	ETV1	3
5081	PAX7	3
84033	OBSCN	5
342667	STAC2	1
342977	NANOS3	2
152137	CCDC50	3
1540	CYLD	1
131096	KCNH8	6
7025	NR2F1	2
8767	RIPK2	3
646643	SBK2	3
3556	IL1RAP	3
2242	FES	3
200576	PIKFYVE	2
8313	AXIN2	2
6733	SRPK2	4
5330	PLCB2	2
4216	MAP3K4	3
284217	LAMA1	5
1992	SERPINB1	6
7016	TESK1	3
22858	ICK	6
94103	ORMDL3	1
6850	SYK	1
83983	TSSK6	6
8643	PTCH2	4
65217	PCDH15	7
54899	PXK	2
23387	SIK3	2
92	ACVR2A	2
29760	BLNK	6
10087	COL4A3BP	1
5591	PRKDC	4
5568	PRKACG	1
124923	SGK494	3
2778	GNAS	1
9590	AKAP12	1
80243	PREX2	2
4605	MYBL2	3
5165	PDK3	6
139285	AMER1	1
8148	TAF15	4
2734	GLG1	5
4058	LTK	3
5289	PIK3C3	4
2050	EPHB4	1
2066	ERBB4	4
10290	SPEG	4
9319	TRIP13	3
2201	FBN2	3
7184	HSP90B1	2
5129	CDK18	3
157753	TMEM74	6
3236	HOXD10	4
5336	PLCG2	3
11143	KAT7	4
10018	BCL2L11	1
27347	STK39	3
58508	KMT2C	1
7157	TP53	2
7704	ZBTB16	4
4173	MCM4	4
6794	STK11	4
7869	SEMA3B	2
8218	CLTCL1	7
3791	KDR	3
10114	HIPK3	1
6184	RPN1	1
54498	SMOX	3
5585	PKN1	3
7249	TSC2	5
65243	ZFP69B	3
11213	IRAK3	1
863	CBFA2T3	6
8874	ARHGEF7	4
51086	TNNI3K	1
2309	FOXO3	3
7038	TG	2
369	ARAF	2
65125	WNK1	6
57591	MRTFA	3
4436	MSH2	3
676	BRDT	3
984	CDK11B	3
2000	ELF4	3
2081	ERN1	3
4026	LPP	6
8997	KALRN	3
23269	MGA	3
57111	RAB25	1
2175	FANCA	2
5371	PML	1
4089	SMAD4	3
54658	UGT1A1	1
6654	SOS1	4
2060	EPS15	3
2668	GDNF	6
4139	MARK1	4
7204	TRIO	2
256536	TCERG1L	4
9252	RPS6KA5	2
78989	COLEC11	4
835	CASP2	2
5727	PTCH1	1
3426	CFI	2
3417	IDH1	1
23678	SGK3	3
5606	MAP2K3	4
5297	PI4KA	5
10926	DBF4	2
10535	RNASEH2A	1
64840	PORCN	2
30827	CXXC1	3
5578	PRKCA	1
7270	TTF1	1
440275	EIF2AK4	3
1198	CLK3	4
2187	FANCB	3
50615	IL21R	5
6046	BRD2	3
3720	JARID2	6
2931	GSK3A	8
26524	LATS2	5
64919	BCL11B	4
675	BRCA2	2
7075	TIE1	2
744	MPPED2	2
1956	EGFR	1
8445	DYRK2	1
2735	GLI1	4
3065	HDAC1	3
4609	MYC	2
11064	CNTRL	3
90956	ADCK2	3
8021	NUP214	4
1459	CSNK2A2	1
26278	SACS	3
51701	NLK	1
5663	PSEN1	2
8900	CCNA1	2
91754	NEK9	3
3949	LDLR	5
7015	TERT	1
6872	TAF1	2
673	BRAF	5
1981	EIF4G1	4
1213	CLTC	3
6011	GRK1	6
84879	MFSD2A	2
120892	LRRK2	4
7301	TYRO3	1
7468	NSD2	3
11184	MAP4K1	3
5128	CDK17	3
460	ASTN1	2
9451	EIF2AK3	2
11262	SP140	6
664	BNIP3	6
23598	PATZ1	6
23396	PIP5K1C	2
23742	NPAP1	6
55521	TRIM36	3
23476	BRD4	4
208	AKT2	3
51592	TRIM33	3
8888	MCM3AP	2
284086	NEK8	4
4317	MMP8	2
2264	FGFR4	4
6498	SKIL	4
79834	PEAK1	3
6789	STK4	2
10257	ABCC4	6
85415	RHPN2	2
6787	NEK4	1
79012	CAMKV	2
10243	GPHN	1
5532	PPP3CB	2
22843	PPM1E	3
65018	PINK1	3
57820	CCNB1IP1	3
4619	MYH1	2
5581	PRKCE	5
9021	SOCS3	2
10111	RAD50	2
5395	PMS2	3
778	CACNA1F	3
53353	LRP1B	1
55289	ACOXL	3
7094	TLN1	1
3181	HNRNPA2B1	6
1281	COL3A1	4
7293	TNFRSF4	5
4000	LMNA	3
3557	IL1RN	3
2130	EWSR1	2
3624	INHBA	3
5587	PRKD1	3
10734	STAG3	3
5589	PRKCSH	3
2321	FLT1	2
2131	EXT1	6
2304	FOXE1	3
3717	JAK2	1
1627	DBN1	7
8899	PRPF4B	3
4067	LYN	4
4772	NFATC1	3
3977	LIFR	6
7112	TMPO	4
4261	CIITA	4
11076	TPPP	2
2122	MECOM	3
51167	CYB5R4	3
1760	DMPK	2
9894	TELO2	6
5925	RB1	6
4217	MAP3K5	5
1026	CDKN1A	3
2074	ERCC6	3
5324	PLAG1	3
81629	TSSK3	3
9878	TOX4	3
3488	IGFBP5	6
50964	SOST	6
23092	ARHGAP26	1
10494	STK25	4
23072	HECW1	3
3237	HOXD11	3
2073	ERCC5	2
79577	CDC73	1
3092	HIP1	4
79966	SCD5	6
4763	NF1	2
57697	FANCM	2
5260	PHKG1	4
1994	ELAVL1	6
1840	DTX1	3
10891	PPARGC1A	1
973	CD79A	3
57096	RPGRIP1	3
94	ACVRL1	4
5287	PIK3C2B	2
814	CAMK4	3
3679	ITGA7	7
7294	TXK	4
2178	FANCE	5
1803	DPP4	1
29110	TBK1	1
2444	FRK	3
4916	NTRK3	3
5624	PROC	3
5970	RELA	4

Gene in drug-gene network: Network Plot

Models in NSC23766

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.