IDH1


Summary: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in IDH1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000287 magnesium ion binding
MF EXP GO:0004450 isocitrate dehydrogenase (NADP+) activity
MF IDA GO:0004450 isocitrate dehydrogenase (NADP+) activity
MF IPI GO:0005102 signaling receptor binding
MF IPI GO:0042802 identical protein binding
MF IPI GO:0042803 protein homodimerization activity
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Gene expression in normal tissue: IDH1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined40ERK MAPK signaling3VEGF signaling pathway2Cell cycle2Metabolism1Cytoskeleton1PI3K/MTOR signaling1Stilbenoid, diarylheptanoid and gingerol biosynthesis1DNA replication1ABL signaling1

Pathways in IDH1


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Database
Pathway ID
Pathway Des.
wikipathways WP100 Glutathione metabolism
wikipathways WP2002 miR-targeted genes in epithelium - TarBase
wikipathways WP2003 miR-targeted genes in leukocytes - TarBase
wikipathways WP2004 miR-targeted genes in lymphocytes - TarBase
wikipathways WP2006 miR-targeted genes in squamous cell - TarBase
wikipathways WP2453 TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD74 Idarubicin 6
iGMDRD399 Selumetinib 4
iGMDRD922 IDH1 inhibitor 3
iGMDRD190 Nilotinib 1
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Gene in drug-gene network: Network Plot

XIAPXIAPTTLTTLLDHALDHAHDAC6HDAC6PRRX1PRRX1ACOD1ACOD1PIP5K1BPIP5K1BSHC1SHC1KLK7KLK7MGAMGAUBR5UBR5GSK3AGSK3AHERC2HERC2TTBK2TTBK2SMG1SMG1WEE1WEE1KDM5AKDM5AMECOMMECOMMYLKMYLKCTNNB1CTNNB1IdarubicinIdarubicinITIH6ITIH6KRASKRASTRRAPTRRAPNLRP1NLRP1CDKN2ACDKN2ACDX2CDX2MAP2K1MAP2K1SMAD4SMAD4BRAFBRAFPIK3CBPIK3CBNRASNRASNF1NF1SelumetinibSelumetinibIDH1 inhibitorIDH1 inhibitorSMARCB1SMARCB1RPS18P13RPS18P13OR4F14POR4F14PUGT1A1UGT1A1RNA5SP365RNA5SP365BRMS1LBRMS1LKITKITABL1ABL1KDM6AKDM6ASNORA27SNORA27ZNF81ZNF81RNU4-72PRNU4-72PNilotinibNilotinibTNFAIP3TNFAIP3HSP90AA1HSP90AA1TSHRTSHRADAMTSL3ADAMTSL3BMP4BMP4EGFREGFRTET2TET2TGX-115TGX-115TTKTTKNEK1NEK1HDAC2HDAC2CREBBPCREBBPC1DC1DOBSCNOBSCNEPHA3EPHA3BRIP1BRIP1ERBB4ERBB4CLTCL1CLTCL1IL17RDIL17RDPIK3CAPIK3CACDH2CDH2NEK9NEK9TOP2ATOP2ARORARORAParbendazoleParbendazoleRANBP17RANBP17ADKADKERBB2ERBB2SYKSYKBTRCBTRCFHITFHITBMI1BMI1PMLPMLPSIP1PSIP1MLLT1MLLT1GRIK1GRIK1ITGA5ITGA5NEK4NEK4DCLK1DCLK1PHKG1PHKG1QuinoclamineQuinoclamineSIK2SIK2AXIN2AXIN2MAST4MAST4TEKTEKPOU2AF1POU2AF1ITKITKSACSSACSADAM32ADAM32NOTCH2NOTCH2PNU-74654PNU-74654IDH2IDH2FLT3FLT3TYRO3TYRO3ABT-199 (GDC-0199)ABT-199 (GDC-0199)MMP2MMP2SMAD3SMAD3PTPRDPTPRDPRAMEPRAMEBNIP3BNIP3IL1RNIL1RNSerdemetanSerdemetanSOX11SOX11NEK6NEK6LETM2LETM2MPLMPLPRKCBPRKCBTNFRSF18TNFRSF18KAT6BKAT6BSMAD2SMAD2TRIP11TRIP11BMPR1BBMPR1BABCC4ABCC4NSD3NSD3RBBP8RBBP8NUDT10NUDT10RB1RB14-methylfasudil4-methylfasudilCDK4CDK4CCND1CCND1PalbociclibPalbociclibHSPB8HSPB8TNK2TNK2TYMSTYMSWNK1WNK1TIE1TIE1RETRETDNAAF3DNAAF3AGERAGERXPCXPCPemetrexedPemetrexedSERPINA2SERPINA2ASXL2ASXL2ATMATMPYGBPYGBTP53TP53SMAD1SMAD1ATRXATRXRNF43RNF43MYCMYCPTPN11PTPN11ASXL1ASXL1MGMTMGMTTemozolomideTemozolomideTXN2TXN2STK11STK1117AAG17AAGARHGAP29ARHGAP29AMER1AMER1NYNRINNYNRINRotenoneRotenonePGRPGRIKZF1IKZF1GUCY1A2GUCY1A2NUTM1NUTM1NR2F1NR2F1PRKXPRKXLAMA1LAMA1MAP3K10MAP3K10XPO5XPO5NIPBLNIPBLRPS6KA5RPS6KA5PORCNPORCNDYRK2DYRK2PTENPTENFLNAFLNAPBX1PBX1BRD63610BRD63610AG120AG120BPTESBPTESGSK321GSK321MYH9MYH9MAP3K1MAP3K1NCAM1NCAM1PRKD1PRKD1Fqi1Fqi1RBM15RBM15RPS6KL1RPS6KL1TSC2TSC2MAP2K3MAP2K3LRRK2LRRK2FANCMFANCMChaetocinChaetocinADAMTS20ADAMTS20MYCLMYCLIKZF3IKZF3STK40STK40MFSD2AMFSD2ACMC4CMC4RPTORRPTORFRKFRKGRIA3GRIA3CYTOCHALASIN BCYTOCHALASIN BNutlin-3Nutlin-3MAP4K5MAP4K5PDCD1PDCD1TENM1TENM1ROBO1ROBO1BRCA2BRCA2EPHA5EPHA5CHM-1CHM-1CDKL2CDKL2P2RX7P2RX7N4BP2N4BP2KMT2CKMT2CKALRNKALRNJARID2JARID2COL3A1COL3A1PDE4DIPPDE4DIPFGFR3FGFR3ZNF331ZNF331LexibulinLexibulinMAP2K4MAP2K4PI4KAPI4KADNAH8DNAH8SalermideSalermideRBL1RBL1GTSE1GTSE1MINK1MINK1STK19STK19RAP1GDS1RAP1GDS1ZFP69BZFP69BERN1ERN1CARSCARSE2F1E2F1EXT1EXT1ITPR2ITPR2SR-II-138ASR-II-138AEP300EP300FBN2FBN2MTUS2MTUS2IFNA2IFNA2Leucascandrolide ALeucascandrolide ALRRC7LRRC7GPR141GPR141ROS1ROS1PIK3C3PIK3C3PHF3PHF3SOS1SOS1EIF2AK4EIF2AK4PDZRN4PDZRN4NRKNRKPALB2PALB2CNTN6CNTN6MAPK10MAPK10PRL-3 Inhibitor IPRL-3 Inhibitor IEPHA2EPHA2DDR2DDR2ZNF296ZNF296CSF3RCSF3RPDGFRAPDGFRAIGFBP2IGFBP2CBLCBLSERPINE1SERPINE1DasatinibDasatinibFESFESSRPK2SRPK2CTDSPLCTDSPLHNF1BHNF1BTAF15TAF15TGTGARAFARAFMSH3MSH3LATS2LATS2LHFPL6LHFPL6GHRGHRDHFRDHFRRo 28-1675Ro 28-1675NF2NF2VHLVHLEPHB4EPHB4VEGFAVEGFAPPP1R15APPP1R15AMMP9MMP9BevacizumabBevacizumabARID1AARID1ATNFRSF1BTNFRSF1BPDGFRBPDGFRBADGRG4ADGRG4PKMYT1PKMYT1CUBNCUBNCDKL1CDKL1BRD7137BRD7137GPR183GPR183HOXD10HOXD10SMOXSMOXMATKMATKCYP27B1CYP27B1DDX1DDX1RHEBRHEBSTK24STK24CIITACIITAMerck60Merck60ALS2ALS2FGFR1FGFR1CYFIP1CYFIP1HDAC4HDAC4MAML1MAML1DLL1DLL1MAP4K2MAP4K2CHD9CHD9ARHGEF12ARHGEF12CFICFIMAP3K12MAP3K12MERTKMERTKRPS6KA6RPS6KA6TAF1TAF1NFKB1NFKB1NPATNPATMST1RMST1RPROCPROCNPC26NPC26NKX2-1NKX2-1FLI1FLI1NFKBIANFKBIAWRNWRNAKAP6AKAP6GAKGAKPICALMPICALMMBIPMBIPPKN2PKN2STK25STK25PARP1PARP1FK 866FK 866UNC13CUNC13CCNTRLCNTRLIL1R1IL1R1PRKCGPRKCGEIF3AEIF3ACurcuminCurcuminNUP210NUP210EPHA7EPHA7ROBO2ROBO2PTCH1PTCH1STAG3STAG3TOX4TOX4GMX1778GMX1778FGRFGRSIX4SIX4ADGRB1ADGRB1FLNCFLNCPIK3CGPIK3CGPIM3PIM3IndisulamIndisulamRNMTRNMTBCL2BCL2FOXA1FOXA1BCL2 inhibitorBCL2 inhibitorZMYM2ZMYM2LMNB1LMNB1MARK4MARK4LASP1LASP1PIP4K2BPIP4K2BTOX3TOX3ARHGEF7ARHGEF7CYP2B6CYP2B6PTK6PTK6WNK2WNK2SUZ12SUZ12DEKDEKGRK2GRK2TriptolideTriptolidePCDH15PCDH15TBK1TBK1Oligomycin AOligomycin AALKALKUNC79UNC79ALDH7A1ALDH7A1LMNB2LMNB2SGK1SGK1LRP6LRP6Ursolic acidUrsolic acidTWF1TWF1NOVA1NOVA1PTPRUPTPRUIRAK4IRAK4GW843682XGW843682XHRASHRASPD-0325901PD-0325901PLX-4720PLX-4720TRPM7TRPM7PKHD1PKHD1DICER1DICER1HOXD13HOXD13GATA2GATA2CSNK2A2CSNK2A2NAV3NAV3MAP3K6MAP3K6NFKB2NFKB2MYH10MYH10MAST2MAST2TRPS1TRPS1CYB5R4CYB5R4MYH11MYH11HUNKHUNKNeratinibNeratinibHMGA2HMGA2CHN1CHN1FOXP1FOXP1BLKBLKPIK3R4PIK3R4ABT-751ABT-751CEBPACEBPATeniposideTeniposideKCNH2KCNH2PHIPPHIPTPH1TPH1CTNNA2CTNNA2PAX3PAX3LRGUKLRGUKPEAK1PEAK1WASWASIsoevodiamineIsoevodiamineCHEK1CHEK1DBN1DBN1ITGA7ITGA7NSC23766NSC23766U2AF1U2AF1SOX17SOX17GSK429286AGSK429286APXDNPXDNFGFR4FGFR4LRP1BLRP1Bnutlin 3nutlin 3AGI-5198AGI-5198CHUKCHUKADAM22ADAM22RIPK2RIPK2CSNK1G3CSNK1G3MSH2MSH2TRIOTRIONEXMIFNEXMIFMK-2206MK-2206CAMK1GCAMK1GNINNINACACAACACACDK12CDK12ISG15ISG15KDRKDRPSKH2PSKH2TFPTTFPTMASTLMASTLFOSFOSPIK3C2GPIK3C2GPIK-75PIK-75IDH1IDH1

Gene-drug targets distribution

Gene Structure: PDB

Models in IDH1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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