iGMDRD190
| Standard Name | CHEMBL | Pubchem CID | DRUGBANK ID | Drug Status | Drug Type |
|---|---|---|---|---|---|
| Nilotinib | CHEMBL255863 CHEMBL1201740 | 644241 | DB04868 | Alone | Small Molecule |
Drug Class:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsBCRP/ABCG2 InhibitorsBCRP/ABCG2 SubstratesCombined Inhibitors of CYP3A4 and P-glycoproteinCombined Inhibitors of CYP3A4 and P-glycoprotein (Strong)Cytochrome P-450 CYP2D6 InhibitorsCytochrome P-450 CYP2D6 Inhibitors (moderate)Cytochrome P-450 CYP3A InhibitorsCytochrome P-450 CYP3A Inhibitors (strong)Cytochrome P-450 CYP3A4 InhibitorsCytochrome P-450 CYP3A4 Inhibitors (strong)Cytochrome P-450 Enzyme InducersCytochrome P-450 Enzyme InhibitorsHeterocyclic CompoundsHeterocyclic Compounds, 1-RingHighest Risk QTc-Prolonging AgentsHyperglycemia-Associated AgentsImmunosuppressive AgentsKinase InhibitorMyelosuppressive AgentsP-glycoprotein/ABCB1 InhibitorsP-glycoprotein/ABCB1 SubstratesProtein Kinase InhibitorsQTc Prolonging AgentsTyrosine Kinase InhibitorsUGT1A1 InhibitorsDrug Pathways:
ABL signalingDrug-model tissue-cancer distribution: Bubble Plot
Drug-gene pathway enrichments
Drug-gene GO enrichments
Drug-Gene: Aster Plot
| Gene ID | Gene Name | Model Num. |
|---|---|---|
| 83940 | TATDN1 | 1 |
| 2956 | MSH6 | 1 |
| 103 | ADAR | 1 |
| 3845 | KRAS | 1 |
| 5295 | PIK3R1 | 1 |
| 8573 | CASK | 1 |
| 6597 | SMARCA4 | 1 |
| 55336 | FBXL8 | 1 |
| 4771 | NF2 | 1 |
| 6598 | SMARCB1 | 2 |
| 100616300 | MIR4710 | 1 |
| 341676 | NEK5 | 1 |
| 1473 | CST5 | 1 |
| 140469 | MYO3B | 1 |
| 100506039 | HMGB3P8 | 1 |
| 6089 | RNY4P3 | 1 |
| 27030 | MLH3 | 1 |
| 148229 | ATP8B3 | 1 |
| 4851 | NOTCH1 | 1 |
| 5332 | PLCB4 | 1 |
| 55294 | FBXW7 | 1 |
| 6927 | HNF1A | 1 |
| 1021 | CDK6 | 1 |
| 4610 | MYCL | 1 |
| 64699 | TMPRSS3 | 1 |
| 102465689 | MIR7152 | 1 |
| 4300 | MLLT3 | 1 |
| 100271364 | RPS18P13 | 2 |
| 51343 | FZR1 | 1 |
| 642935 | ADAMTS7P4 | 1 |
| 131118 | DNAJC19 | 1 |
| 154064 | RAET1L | 1 |
| 7428 | VHL | 1 |
| 2064 | ERBB2 | 1 |
| 6416 | MAP2K4 | 1 |
| 3212 | HOXB2 | 1 |
| 390650 | OR4F14P | 2 |
| 2778 | GNAS | 1 |
| 139285 | AMER1 | 1 |
| 101929480 | LOC101929480 | 1 |
| 1029 | CDKN2A | 1 |
| 3052 | HCCS | 1 |
| 861 | RUNX1 | 1 |
| 7157 | TP53 | 1 |
| 6794 | STK11 | 1 |
| 3791 | KDR | 1 |
| 4292 | MLH1 | 1 |
| 54498 | SMOX | 1 |
| 100616220 | MIR4736 | 1 |
| 1019 | CDK4 | 1 |
| 285419 | LINC01091 | 1 |
| 339398 | LINGO4 | 1 |
| 219623 | TMEM26 | 1 |
| 653316 | FAM153C | 1 |
| 116447 | TOP1MT | 1 |
| 8923202 | COX2 | 1 |
| 26811 | SNORD55 | 1 |
| 57111 | RAB25 | 1 |
| 29072 | SETD2 | 1 |
| 4089 | SMAD4 | 1 |
| 54658 | UGT1A1 | 3 |
| 6398 | SECTM1 | 1 |
| 3417 | IDH1 | 1 |
| 554203 | JPX | 1 |
| 56656 | OR2S2 | 1 |
| 8731 | RNMT | 1 |
| 5290 | PIK3CA | 1 |
| 675 | BRCA2 | 1 |
| 84962 | AJUBA | 1 |
| 1956 | EGFR | 1 |
| 100873624 | RNA5SP365 | 2 |
| 4609 | MYC | 1 |
| 1031 | CDKN2C | 1 |
| 253738 | EBF3 | 1 |
| 5156 | PDGFRA | 1 |
| 106480835 | RNU7-200P | 1 |
| 312 | ANXA13 | 1 |
| 106481049 | RN7SL464P | 1 |
| 673 | BRAF | 1 |
| 22 | ABCB7 | 1 |
| 9321 | TRIP11 | 1 |
| 5728 | PTEN | 1 |
| 208 | AKT2 | 1 |
| 26298 | EHF | 1 |
| 171023 | ASXL1 | 1 |
| 59352 | LGR6 | 1 |
| 7553 | ZNF7 | 1 |
| 100288687 | DUX4 | 1 |
| 951 | CD37 | 1 |
| 29994 | BAZ2B | 1 |
| 7248 | TSC1 | 1 |
| 3297 | HSF1 | 1 |
| 84312 | BRMS1L | 2 |
| 4253 | MIA2 | 1 |
| 163702 | IFNLR1 | 1 |
| 266700 | BMP6P1 | 1 |
| 9903 | KLHL21 | 1 |
| 3717 | JAK2 | 1 |
| 27004 | TCL6 | 1 |
| 79608 | RIC3 | 1 |
| 147463 | ANKRD29 | 1 |
| 3815 | KIT | 60 |
| 5925 | RB1 | 1 |
| 4893 | NRAS | 2 |
| 25 | ABL1 | 29 |
| 7403 | KDM6A | 2 |
| 2261 | FGFR3 | 1 |
| 321 | APBA2 | 1 |
| 28732 | TRAJ23 | 1 |
| 581 | BAX | 1 |
| 619499 | SNORA27 | 2 |
| 595 | CCND1 | 1 |
| 4763 | NF1 | 7 |
| 4613 | MYCN | 1 |
| 3265 | HRAS | 1 |
| 4482 | MSRA | 1 |
| 4193 | MDM2 | 1 |
| 1499 | CTNNB1 | 1 |
| 5967 | REG1A | 1 |
| 2146 | EZH2 | 1 |
| 347344 | ZNF81 | 2 |
| 106479591 | RNU4-72P | 2 |
| 5624 | PROC | 1 |
Gene in drug-gene network: Network Plot
Models in Nilotinib
CLASSFICATION
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