CD37


Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It may play a role in T-cell-B-cell interactions. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
CD37 moleculeMIM:151523Ensembl:ENSG00000104894HGNC:HGNC:1666PA2621319q13.33

Gene Categories:

DRUGGABLE GENOME

GO terms in CD37


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
CCIDAGO:0001772immunological synapse
CCIBAGO:0005887integral component of plasma membrane
CCHDAGO:0016020membrane
CCHDAGO:0070062extracellular exosome
BPIBAGO:0007166cell surface receptor signaling pathway

Gene expression in normal tissue: CD37

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CD37


DatabasePathway IDPathway Des.
kegghsa04640Hematopoietic cell lineage - Homo sapiens (human)
wikipathwaysWP3945TYROBP Causal Network

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD190Nilotinib1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CD37

​​​​