EBF3
Summary: This gene encodes a member of the early B-cell factor (EBF) family of DNA binding transcription factors. EBF proteins are involved in B-cell differentiation, bone development and neurogenesis, and may also function as tumor suppressors. The encoded protein inhibits cell survival through the regulation of genes involved in cell cycle arrest and apoptosis, and aberrant methylation or deletion of this gene may play a role in multiple malignancies including glioblastoma multiforme and gastric carcinoma. [provided by RefSeq, Sep 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:607407 Ensembl IDEnsembl:ENSG00000108001 HGNC IDHGNC:HGNC:19087 PHARMGKB IDPA134972607 Map Location10q26.3 | |||||
GO terms in EBF3
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0007275 | multicellular organism development |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| CC | IBA | GO:0005634 | nucleus |
Gene expression in normal tissue: EBF3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EBF3
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2895 | Differentiation of white and brown adipocyte |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD190 | Nilotinib | 1 |
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Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EBF3
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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