LGR6
Summary: This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| leucine rich repeat containing G protein-coupled receptor 6 | MIM:606653 | Ensembl:ENSG00000133067 | HGNC:HGNC:19719 | PA134927114 | 1q32.1 |
GO terms in LGR6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | IDA | GO:0030177 | positive regulation of Wnt signaling pathway |
| BP | IDA | GO:0030335 | positive regulation of cell migration |
| BP | ISS | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | IEA | GO:1990523 | bone regeneration |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | ISS | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0031982 | vesicle |
| CC | ISS | GO:0032588 | trans-Golgi network membrane |
| MF | ISS | GO:0004888 | transmembrane signaling receptor activity |
| MF | ISS | GO:0004930 | G-protein coupled receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0016500 | protein-hormone receptor activity |
Gene expression in normal tissue: LGR6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LGR6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-4641263 | Regulation of FZD by ubiquitination |
| wikipathways | WP117 | GPCRs, Other |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LGR6
CLASSFICATION
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