PIK3CA
Summary: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | MIM:171834 | Ensembl:ENSG00000121879 | HGNC:HGNC:8975 | PA33308 | 3q26.32 |
GO terms in PIK3CA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IEA | GO:0001889 | liver development |
| BP | TAS | GO:0001944 | vasculature development |
| BP | IEA | GO:0006006 | glucose metabolic process |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IEA | GO:0010468 | regulation of gene expression |
| BP | IBA | GO:0014065 | phosphatidylinositol 3-kinase signaling |
| BP | NAS | GO:0016242 | negative regulation of macroautophagy |
| BP | IDA | GO:0016310 | phosphorylation |
| BP | IBA | GO:0016477 | cell migration |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IBA | GO:0030168 | platelet activation |
| BP | TAS | GO:0030168 | platelet activation |
| BP | TAS | GO:0031295 | T cell costimulation |
| BP | NAS | GO:0032008 | positive regulation of TOR signaling |
| BP | IEA | GO:0032147 | activation of protein kinase activity |
| BP | IEA | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IBA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | IEA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | TAS | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | TAS | GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis |
| BP | TAS | GO:0038128 | ERBB2 signaling pathway |
| BP | IEA | GO:0040014 | regulation of multicellular organism growth |
| BP | NAS | GO:0043276 | anoikis |
| BP | IEA | GO:0043457 | regulation of cellular respiration |
| BP | IEA | GO:0043491 | protein kinase B signaling |
| BP | IEA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | TAS | GO:0043542 | endothelial cell migration |
| BP | IEA | GO:0044029 | hypomethylation of CpG island |
| BP | IBA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | ISS | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | IBA | GO:0048015 | phosphatidylinositol-mediated signaling |
| BP | TAS | GO:0048015 | phosphatidylinositol-mediated signaling |
| BP | TAS | GO:0050852 | T cell receptor signaling pathway |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | TAS | GO:0060048 | cardiac muscle contraction |
| BP | IEA | GO:0060612 | adipose tissue development |
| BP | IEA | GO:0071333 | cellular response to glucose stimulus |
| BP | IEA | GO:0097009 | energy homeostasis |
| BP | IEA | GO:2000270 | negative regulation of fibroblast apoptotic process |
| BP | IEA | GO:2000653 | regulation of genetic imprinting |
| BP | IMP | GO:2000811 | negative regulation of anoikis |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005942 | phosphatidylinositol 3-kinase complex |
| CC | ISS | GO:0005942 | phosphatidylinositol 3-kinase complex |
| CC | IBA | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA |
| CC | IDA | GO:0005943 | phosphatidylinositol 3-kinase complex, class IA |
| CC | IBA | GO:0016020 | membrane |
| CC | IEA | GO:0030027 | lamellipodium |
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016301 | kinase activity |
| MF | TAS | GO:0016301 | kinase activity |
| MF | IBA | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | IDA | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | TAS | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | IEA | GO:0030295 | protein kinase activator activity |
| MF | ISS | GO:0035004 | phosphatidylinositol 3-kinase activity |
| MF | TAS | GO:0035004 | phosphatidylinositol 3-kinase activity |
| MF | IBA | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity |
| MF | IEA | GO:0043560 | insulin receptor substrate binding |
| MF | IBA | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| MF | IBA | GO:0052742 | phosphatidylinositol kinase activity |
Gene expression in normal tissue: PIK3CA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PIK3CA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04140 | Autophagy - animal - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04380 | Osteoclast differentiation - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| kegg | hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa04923 | Regulation of lipolysis in adipocytes - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa04930 | Type II diabetes mellitus - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa04960 | Aldosterone-regulated sodium reabsorption - Homo sapiens (human) |
| kegg | hsa04973 | Carbohydrate digestion and absorption - Homo sapiens (human) |
| kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05146 | Amoebiasis - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| kegg | hsa05213 | Endometrial cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05218 | Melanoma - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| kegg | hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| humancyc | PWY-6352 | 3-phosphoinositide biosynthesis |
| humancyc | PWY-6371 | superpathway of inositol phosphate compounds |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-109704 | PI3K Cascade |
| reactome | R-HSA-112399 | IRS-mediated signalling |
| reactome | R-HSA-114604 | GPVI-mediated activation cascade |
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1227986 | Signaling by ERBB2 |
| reactome | R-HSA-1236382 | Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants |
| reactome | R-HSA-1236394 | Signaling by ERBB4 |
| reactome | R-HSA-1250342 | PI3K events in ERBB4 signaling |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-1483255 | PI Metabolism |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643713 | Signaling by EGFR in Cancer |
| reactome | R-HSA-1660499 | Synthesis of PIPs at the plasma membrane |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-180292 | GAB1 signalosome |
| reactome | R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants |
| reactome | R-HSA-1839124 | FGFR1 mutant receptor activation |
| reactome | R-HSA-186763 | Downstream signal transduction |
| reactome | R-HSA-186797 | Signaling by PDGF |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-1963642 | PI3K events in ERBB2 signaling |
| reactome | R-HSA-198203 | PI3K/AKT activation |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202424 | Downstream TCR signaling |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis |
| reactome | R-HSA-2029485 | Role of phospholipids in phagocytosis |
| reactome | R-HSA-210993 | Tie2 Signaling |
| reactome | R-HSA-2172127 | DAP12 interactions |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2424491 | DAP12 signaling |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428928 | IRS-related events triggered by IGF1R |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2730905 | Role of LAT2/NTAL/LAB on calcium mobilization |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373753 | Nephrin family interactions |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389356 | CD28 co-stimulation |
| reactome | R-HSA-389357 | CD28 dependent PI3K/Akt signaling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-416482 | G alpha (12/13) signalling events |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5637810 | Constitutive Signaling by EGFRvIII |
| reactome | R-HSA-5637812 | Signaling by EGFRvIII in Cancer |
| reactome | R-HSA-5637815 | Signaling by Ligand-Responsive EGFR Variants in Cancer |
| reactome | R-HSA-5654687 | Downstream signaling of activated FGFR1 |
| reactome | R-HSA-5654689 | PI-3K cascade:FGFR1 |
| reactome | R-HSA-5654695 | PI-3K cascade:FGFR2 |
| reactome | R-HSA-5654696 | Downstream signaling of activated FGFR2 |
| reactome | R-HSA-5654708 | Downstream signaling of activated FGFR3 |
| reactome | R-HSA-5654710 | PI-3K cascade:FGFR3 |
| reactome | R-HSA-5654716 | Downstream signaling of activated FGFR4 |
| reactome | R-HSA-5654720 | PI-3K cascade:FGFR4 |
| reactome | R-HSA-5654736 | Signaling by FGFR1 |
| reactome | R-HSA-5654738 | Signaling by FGFR2 |
| reactome | R-HSA-5654741 | Signaling by FGFR3 |
| reactome | R-HSA-5654743 | Signaling by FGFR4 |
| reactome | R-HSA-5655253 | Signaling by FGFR2 in disease |
| reactome | R-HSA-5655291 | Signaling by FGFR4 in disease |
| reactome | R-HSA-5655302 | Signaling by FGFR1 in disease |
| reactome | R-HSA-5655332 | Signaling by FGFR3 in disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-6806834 | Signaling by MET |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-8851907 | MET activates PI3K/AKT signaling |
| reactome | R-HSA-8853334 | Signaling by FGFR3 fusions in cancer |
| reactome | R-HSA-8853338 | Signaling by FGFR3 point mutants in cancer |
| reactome | R-HSA-8853659 | RET signaling |
| reactome | R-HSA-9006115 | Signaling by NTRK2 (TRKB) |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9028335 | Activated NTRK2 signals through PI3K |
| reactome | R-HSA-9034015 | Signaling by NTRK3 (TRKC) |
| reactome | R-HSA-912526 | Interleukin receptor SHC signaling |
| reactome | R-HSA-912631 | Regulation of signaling by CBL |
| reactome | R-HSA-912631 | Regulation of signaling by CBL |
| reactome | R-HSA-9603381 | Activated NTRK3 signals through PI3K |
| biocarta | achpathway | role of nicotinic acetylcholine receptors in the regulation of apoptosis |
| biocarta | aktpathway | akt signaling pathway |
| biocarta | arfpathway | tumor suppressor arf inhibits ribosomal biogenesis |
| biocarta | badpathway | regulation of bad phosphorylation |
| biocarta | bcellsurvivalpathway | b cell survival pathway |
| biocarta | biopeptidespathway | bioactive peptide induced signaling pathway |
| biocarta | cdc42racpathway | role of pi3k subunit p85 in regulation of actin organization and cell migration |
| biocarta | crebpathway | transcription factor creb and its extracellular signals |
| biocarta | ctcfpathway | ctcf: first multivalent nuclear factor |
| biocarta | ctla4pathway | the co-stimulatory signal during t-cell activation |
| biocarta | cxcr4pathway | cxcr4 signaling pathway |
| biocarta | ecmpathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia |
| biocarta | edg1pathway | phospholipids as signalling intermediaries |
| biocarta | egfpathway | egf signaling pathway |
| biocarta | eif4pathway | regulation of eif-4e and p70s6 kinase |
| biocarta | erk5pathway | role of erk5 in neuronal survival pathway |
| biocarta | fcer1pathway | fc epsilon receptor i signaling in mast cells |
| biocarta | gcrpathway | corticosteroids and cardioprotection |
| biocarta | ghpathway | growth hormone signaling pathway |
| biocarta | gleevecpathway | inhibition of cellular proliferation by gleevec |
| biocarta | gsk3pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages |
| biocarta | hcmvpathway | human cytomegalovirus and map kinase pathways |
| biocarta | hdacpathway | control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) |
| biocarta | her2pathway | role of erbb2 in signal transduction and oncology |
| biocarta | igf1mtorpathway | skeletal muscle hypertrophy is regulated via akt-mtor pathway |
| biocarta | igf1pathway | igf-1 signaling pathway |
| biocarta | igf1rpathway | multiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| biocarta | il7pathway | il-7 signal transduction |
| biocarta | insulinpathway | insulin signaling pathway |
| biocarta | longevitypathway | the igf-1 receptor and longevity |
| biocarta | mtorpathway | mtor signaling pathway |
| biocarta | nfatpathway | nfat and hypertrophy of the heart |
| biocarta | ngfpathway | nerve growth factor pathway (ngf) |
| biocarta | nkcellspathway | ras-independent pathway in nk cell-mediated cytotoxicity |
| biocarta | no1pathway | actions of nitric oxide in the heart |
| biocarta | par1pathway | thrombin signaling and protease-activated receptors |
| biocarta | pdgfpathway | pdgf signaling pathway |
| biocarta | plcpathway | phospholipase c signaling pathway |
| biocarta | ptenpathway | pten dependent cell cycle arrest and apoptosis |
| biocarta | rac1pathway | rac1 cell motility signaling pathway |
| biocarta | raccycdpathway | influence of ras and rho proteins on g1 to s transition |
| biocarta | raspathway | ras signaling pathway |
| biocarta | tcrpathway | t cell receptor signaling pathway |
| biocarta | tffpathway | trefoil factors initiate mucosal healing |
| biocarta | tpopathway | tpo signaling pathway |
| biocarta | trkapathway | trka receptor signaling pathway |
| biocarta | vegfpathway | vegf hypoxia and angiogenesis |
| pid | a6b1_a6b4_integrin_pathway | a6b1 and a6b4 Integrin signaling |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | ar_nongenomic_pathway | Nongenotropic Androgen signaling |
| pid | avb3_integrin_pathway | Integrins in angiogenesis |
| pid | avb3_opn_pathway | Osteopontin-mediated events |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | cd40_pathway | CD40/CD40L signaling |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | cxcr3pathway | CXCR3-mediated signaling events |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | ecadherin_keratinocyte_pathway | E-cadherin signaling in keratinocytes |
| pid | ecadherin_nascentaj_pathway | E-cadherin signaling in the nascent adherens junction |
| pid | epha2_fwdpathway | EPHA2 forward signaling |
| pid | ephbfwdpathway | EPHB forward signaling |
| pid | ephrinbrevpathway | Ephrin B reverse signaling |
| pid | er_nongenomic_pathway | Plasma membrane estrogen receptor signaling |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | erbb1_internalization_pathway | Internalization of ErbB1 |
| pid | erbb2erbb3pathway | ErbB2/ErbB3 signaling events |
| pid | erbb4_pathway | ErbB4 signaling events |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | faspathway | FAS (CD95) signaling pathway |
| pid | fcer1pathway | Fc-epsilon receptor I signaling in mast cells |
| pid | fgf_pathway | FGF signaling pathway |
| pid | gmcsf_pathway | GMCSF-mediated signaling events |
| pid | hedgehog_2pathway | Signaling events mediated by the Hedgehog family |
| pid | ifngpathway | IFN-gamma pathway |
| pid | igf1_pathway | IGF1 pathway |
| pid | il1pathway | IL1-mediated signaling events |
| pid | il23pathway | IL23-mediated signaling events |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il2_pi3kpathway | IL2 signaling events mediated by PI3K |
| pid | il2_stat5pathway | IL2 signaling events mediated by STAT5 |
| pid | il3_pathway | IL3-mediated signaling events |
| pid | il4_2pathway | IL4-mediated signaling events |
| pid | il5_pathway | IL5-mediated signaling events |
| pid | il6_7pathway | IL6-mediated signaling events |
| pid | insulin_pathway | Insulin Pathway |
| pid | kitpathway | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| pid | lymphangiogenesis_pathway | VEGFR3 signaling in lymphatic endothelium |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | ncadherinpathway | N-cadherin signaling events |
| pid | nectin_pathway | Nectin adhesion pathway |
| pid | nephrin_neph1_pathway | Nephrin/Neph1 signaling in the kidney podocyte |
| pid | netrin_pathway | Netrin-mediated signaling events |
| pid | nfkappabatypicalpathway | Atypical NF-kappaB pathway |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | pdgfrapathway | PDGFR-alpha signaling pathway |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | pi3kcipathway | Class I PI3K signaling events |
| pid | pi3kplctrkpathway | Trk receptor signaling mediated by PI3K and PLC-gamma |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | reelinpathway | Reelin signaling pathway |
| pid | ret_pathway | Signaling events regulated by Ret tyrosine kinase |
| pid | s1p_s1p2_pathway | S1P2 pathway |
| pid | shp2_pathway | SHP2 signaling |
| pid | tcptp_pathway | Signaling events mediated by TCPTP |
| pid | thrombin_par1_pathway | PAR1-mediated thrombin signaling events |
| pid | trail_pathway | TRAIL signaling pathway |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| pid | vegfr1_pathway | VEGFR1 specific signals |
| pharmgkb | PA153627758 | Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA165959584 | Sorafenib Pharmacodynamics |
| smpdb | SMP00011 | Inositol Metabolism |
| smpdb | SMP00320 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine |
| smpdb | SMP00321 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |
| smpdb | SMP00358 | Fc Epsilon Receptor I Signaling in Mast Cells |
| smpdb | SMP00463 | Phosphatidylinositol Phosphate Metabolism |
| smpdb | SMP00582 | Joubert syndrome |
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP1539 | Angiogenesis |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP1982 | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP2038 | Regulation of Microtubule Cytoskeleton |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2263 | Androgen Receptor Network in Prostate Cancer |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2865 | IL1 and megakaryocytes in obesity |
| wikipathways | WP3 | Transcriptional activation by NRF2 |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP313 | Signaling of Hepatocyte Growth Factor Receptor |
| wikipathways | WP3286 | Copper homeostasis |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
| wikipathways | WP3844 | PI3K-AKT-mTOR signaling pathway and therapeutic opportunities |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3937 | Microglia Pathogen Phagocytosis Pathway |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP3972 | PDGFR-beta pathway |
| wikipathways | WP3981 | miRNA regulation of prostate cancer signaling pathways |
| wikipathways | WP4141 | PI3K-AKT-mTOR - VitD3 Signalling |
| wikipathways | WP4155 | Endometrial cancer |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4205 | MET in type 1 papillary renal cell carcinoma |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| wikipathways | WP524 | G13 Signaling Pathway |
| wikipathways | WP710 | DNA Damage Response (only ATM dependent) |
| wikipathways | WP712 | Estrogen signaling pathway |
| wikipathways | WP722 | Serotonin HTR1 Group and FOS Pathway |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD590 | AZD5363 | 4 |
| iGMDRD980 | PI3K alpha inhibitor | 3 |
| iGMDRD276 | AS 605240 | 1 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD698 | Neratinib | 4 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD879 | chemotherapy | 1 |
| iGMDRD123 | Isoevodiamine | 7 |
| iGMDRD5 | Tyrphostin AG 1478 | 6 |
| iGMDRD293 | Bleomycin | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD121 | GMX1778 | 4 |
| iGMDRD213 | SMR000068650 | 4 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD455 | Idelalisib | 1 |
| iGMDRD993 | QL-XII-61 | 1 |
| iGMDRD119 | Temsirolimus | 3 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD749 | ZINC6718453 | 1 |
| iGMDRD433 | Lexibulin | 6 |
| iGMDRD409 | Saracatinib | 2 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD397 | Pazopanib | 1 |
| iGMDRD670 | ML 210 | 1 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD748 | PHA-665752 | 1 |
| iGMDRD470 | Trametinib | 1 |
| iGMDRD778 | SCHEMBL13586708 | 1 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD466 | Chaetocin | 1 |
| iGMDRD816 | anti-EGFR mAbs | 1 |
| iGMDRD888 | Compound 44 | 4 |
| iGMDRD11 | Aspirin in adjuvant setting | 1 |
| iGMDRD982 | PI3K Inhibitor | 1 |
| iGMDRD133 | Lapatinib | 2 |
| iGMDRD880 | chemotherapy (HER2 ampl) | 1 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD512 | nutlin 3 | 6 |
| iGMDRD792 | Cetuximab | 10 |
| iGMDRD148 | Pifithrin-mu | 1 |
| iGMDRD10 | Aspirin | 1 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD435 | BI-2536 | 1 |
| iGMDRD310 | Everolimus | 7 |
| iGMDRD807 | Ado-trastuzumab emtansine | 2 |
| iGMDRD481 | Dactolisib | 4 |
| iGMDRD267 | Oligomycin A | 11 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD967 | Panitumumab | 5 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD579 | PF750 | 6 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD129 | SB-216763 | 1 |
| iGMDRD638 | Ribociclib | 1 |
| iGMDRD986 | PIK3CA inhibitor | 3 |
| iGMDRD446 | LY 2183240 | 5 |
| iGMDRD498 | GW441756X | 1 |
| iGMDRD280 | CYTOCHALASIN B | 7 |
| iGMDRD134 | Sorafenib | 1 |
| iGMDRD480 | KU0060648 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD309 | 17AAG | 4 |
| iGMDRD727 | Alpelisib | 9 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD454 | JNK Inhibitor VIII | 1 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD324 | CI-1040 | 1 |
| iGMDRD564 | GSK-650394 | 1 |
| iGMDRD523 | Cyanoquinoline, 11 | 4 |
| iGMDRD520 | Pictilisib | 5 |
| iGMDRD532 | Olaparib | 1 |
| iGMDRD738 | PP-242 | 1 |
| iGMDRD683 | Taselisib | 3 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD605 | AZD6482 | 2 |
| iGMDRD945 | ML214 | 8 |
| iGMDRD402 | AKT Inhibitor VIII | 4 |
| iGMDRD101 | Fulvestrant | 3 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD105 | Triptolide | 7 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD839 | BRAF inhibitor | 1 |
| iGMDRD263 | AACOCF3 | 1 |
| iGMDRD118 | Perifosine | 2 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD571 | Cabozantinib | 1 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD507 | GSK690693 | 5 |
| iGMDRD474 | Avrainvillamide | 4 |
| iGMDRD996 | Radiation | 1 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD983 | PI3K pathway inhibitor | 55 |
| iGMDRD284 | Palbociclib | 2 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD74 | Idarubicin | 1 |
| iGMDRD874 | BRD8958 | 2 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD190 | Nilotinib | 1 |
| iGMDRD64 | Parbendazole | 7 |
| iGMDRD1020 | Trastuzumab | 9 |
| iGMDRD486 | Tosedostat | 9 |
| iGMDRD456 | Crizotinib | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 6 |
| iGMDRD984 | PI3K pathway inhibitor (alone or in combination) | 9 |
| iGMDRD592 | Apitolisib | 2 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD271 | Brefeldin A | 1 |
| iGMDRD459 | RO-3306 | 1 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD415 | LE-135 | 5 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD872 | BRD7137 | 9 |
| iGMDRD472 | PF-562271 | 1 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD136 | Nutlin-3 | 1 |
| iGMDRD193 | Fqi1 | 6 |
| iGMDRD671 | CH5132799 | 2 |
| iGMDRD519 | GDC-0941 | 1 |
| iGMDRD518 | 2-(1H-Indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine | 1 |
| iGMDRD686 | PF4708671 | 1 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD401 | Afatinib | 2 |
| iGMDRD673 | LSM-1215 | 2 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD109 | Gefitinib | 2 |
| iGMDRD422 | Regorafenib | 1 |
| iGMDRD491 | TAE-684 | 1 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD478 | ABT-888 | 1 |
| iGMDRD441 | TW 37 | 4 |
| iGMDRD782 | DC-45-A2 | 1 |
| iGMDRD586 | Ridaforolimus | 1 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD398 | Sepantronium | 1 |
| iGMDRD596 | Vemurafenib | 1 |
| iGMDRD60 | Quinoclamine | 8 |
| iGMDRD131 | Erlotinib | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PIK3CA
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.