PIK3CA

Summary: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namephosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
OMIM IDMIM:171834
Ensembl IDEnsembl:ENSG00000121879
HGNC IDHGNC:HGNC:8975
PHARMGKB IDPA33308
Map Location3q26.32

GO terms in PIK3CA


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0001525 angiogenesis
BP IEA GO:0001889 liver development
BP TAS GO:0001944 vasculature development
BP IEA GO:0006006 glucose metabolic process
BP IBA GO:0006468 protein phosphorylation
BP TAS GO:0007173 epidermal growth factor receptor signaling pathway
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Gene expression in normal tissue: PIK3CA

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined94PI3K/MTOR signaling14RTK signaling6ERK MAPK signaling5Apoptosis regulation4EGFR signaling4Other, kinases3Cell cycle3Biosynthesis of secondary metabolites2Genome integrity2

Pathways in PIK3CA


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Database
Pathway ID
Pathway Des.
kegg hsa00562 Inositol phosphate metabolism - Homo sapiens (human)
kegg hsa04012 ErbB signaling pathway - Homo sapiens (human)
kegg hsa04014 Ras signaling pathway - Homo sapiens (human)
kegg hsa04015 Rap1 signaling pathway - Homo sapiens (human)
kegg hsa04024 cAMP signaling pathway - Homo sapiens (human)
kegg hsa04062 Chemokine signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD590 AZD5363 4
iGMDRD980 PI3K alpha inhibitor 3
iGMDRD276 AS 605240 1
iGMDRD79 Gemcitabine 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PIK3CA

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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