PIK3CA


Summary: Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. A pseudogene of this gene has been defined on chromosome 22. [provided by RefSeq, Apr 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaMIM:171834Ensembl:ENSG00000121879HGNC:HGNC:8975PA333083q26.32

GO terms in PIK3CA


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001525angiogenesis
BPIEAGO:0001889liver development
BPTASGO:0001944vasculature development
BPIEAGO:0006006glucose metabolic process
BPIBAGO:0006468protein phosphorylation
BPTASGO:0007173epidermal growth factor receptor signaling pathway
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007411axon guidance
BPIEAGO:0010468regulation of gene expression
BPIBAGO:0014065phosphatidylinositol 3-kinase signaling
BPNASGO:0016242negative regulation of macroautophagy
BPIDAGO:0016310phosphorylation
BPIBAGO:0016477cell migration
BPTASGO:0019221cytokine-mediated signaling pathway
BPIBAGO:0030168platelet activation
BPTASGO:0030168platelet activation
BPTASGO:0031295T cell costimulation
BPNASGO:0032008positive regulation of TOR signaling
BPIEAGO:0032147activation of protein kinase activity
BPIEAGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIBAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPIEAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPTASGO:0038028insulin receptor signaling pathway via phosphatidylinositol 3-kinase
BPTASGO:0038095Fc-epsilon receptor signaling pathway
BPTASGO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis
BPTASGO:0038128ERBB2 signaling pathway
BPIEAGO:0040014regulation of multicellular organism growth
BPNASGO:0043276anoikis
BPIEAGO:0043457regulation of cellular respiration
BPIEAGO:0043491protein kinase B signaling
BPIEAGO:0043524negative regulation of neuron apoptotic process
BPTASGO:0043542endothelial cell migration
BPIEAGO:0044029hypomethylation of CpG island
BPIBAGO:0046854phosphatidylinositol phosphorylation
BPISSGO:0046854phosphatidylinositol phosphorylation
BPTASGO:0048010vascular endothelial growth factor receptor signaling pathway
BPIBAGO:0048015phosphatidylinositol-mediated signaling
BPTASGO:0048015phosphatidylinositol-mediated signaling
BPTASGO:0050852T cell receptor signaling pathway
BPTASGO:0050900leukocyte migration
BPTASGO:0051897positive regulation of protein kinase B signaling
BPTASGO:0060048cardiac muscle contraction
BPIEAGO:0060612adipose tissue development
BPIEAGO:0071333cellular response to glucose stimulus
BPIEAGO:0097009energy homeostasis
BPIEAGO:2000270negative regulation of fibroblast apoptotic process
BPIEAGO:2000653regulation of genetic imprinting
BPIMPGO:2000811negative regulation of anoikis
CCIBAGO:0005737cytoplasm
CCTASGO:0005829cytosol
CCIBAGO:0005886plasma membrane
CCIBAGO:0005942phosphatidylinositol 3-kinase complex
CCISSGO:0005942phosphatidylinositol 3-kinase complex
CCIBAGO:0005943phosphatidylinositol 3-kinase complex, class IA
CCIDAGO:0005943phosphatidylinositol 3-kinase complex, class IA
CCIBAGO:0016020membrane
CCIEAGO:0030027lamellipodium
MFIEAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0016301kinase activity
MFTASGO:0016301kinase activity
MFIBAGO:00163031-phosphatidylinositol-3-kinase activity
MFIDAGO:00163031-phosphatidylinositol-3-kinase activity
MFTASGO:00163031-phosphatidylinositol-3-kinase activity
MFIEAGO:0030295protein kinase activator activity
MFISSGO:0035004phosphatidylinositol 3-kinase activity
MFTASGO:0035004phosphatidylinositol 3-kinase activity
MFIBAGO:00350051-phosphatidylinositol-4-phosphate 3-kinase activity
MFIEAGO:0043560insulin receptor substrate binding
MFIBAGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity
MFTASGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity
MFIBAGO:0052742phosphatidylinositol kinase activity

Gene expression in normal tissue: PIK3CA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PIK3CA


DatabasePathway IDPathway Des.
kegghsa00562Inositol phosphate metabolism - Homo sapiens (human)
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04213Longevity regulating pathway - multiple species - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04360Axon guidance - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04650Natural killer cell mediated cytotoxicity - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04662B cell receptor signaling pathway - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04666Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04923Regulation of lipolysis in adipocytes - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04930Type II diabetes mellitus - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa04960Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
kegghsa04973Carbohydrate digestion and absorption - Homo sapiens (human)
kegghsa05100Bacterial invasion of epithelial cells - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05210Colorectal cancer - Homo sapiens (human)
kegghsa05211Renal cell carcinoma - Homo sapiens (human)
kegghsa05212Pancreatic cancer - Homo sapiens (human)
kegghsa05213Endometrial cancer - Homo sapiens (human)
kegghsa05214Glioma - Homo sapiens (human)
kegghsa05215Prostate cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)
kegghsa05231Choline metabolism in cancer - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
humancycPWY-63523-phosphoinositide biosynthesis
humancycPWY-6371superpathway of inositol phosphate compounds
netpathPathway_Alpha6Beta4IntegrinAlpha6Beta4Integrin
netpathPathway_EGFR1EGFR1
netpathPathway_IL2IL2
netpathPathway_IL4IL4
netpathPathway_KitReceptorKitReceptor
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-109704PI3K Cascade
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-114604GPVI-mediated activation cascade
reactomeR-HSA-1226099Signaling by FGFR in disease
reactomeR-HSA-1227986Signaling by ERBB2
reactomeR-HSA-1236382Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
reactomeR-HSA-1236394Signaling by ERBB4
reactomeR-HSA-1250342PI3K events in ERBB4 signaling
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1433557Signaling by SCF-KIT
reactomeR-HSA-1483255PI Metabolism
reactomeR-HSA-1483257Phospholipid metabolism
reactomeR-HSA-1500931Cell-Cell communication
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-1643713Signaling by EGFR in Cancer
reactomeR-HSA-1660499Synthesis of PIPs at the plasma membrane
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-177929Signaling by EGFR
reactomeR-HSA-180292GAB1 signalosome
reactomeR-HSA-1839117Signaling by cytosolic FGFR1 fusion mutants
reactomeR-HSA-1839124FGFR1 mutant receptor activation
reactomeR-HSA-186763Downstream signal transduction
reactomeR-HSA-186797Signaling by PDGF
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-190236Signaling by FGFR
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-1963642PI3K events in ERBB2 signaling
reactomeR-HSA-198203PI3K/AKT activation
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-202403TCR signaling
reactomeR-HSA-202424Downstream TCR signaling
reactomeR-HSA-202733Cell surface interactions at the vascular wall
reactomeR-HSA-2029480Fcgamma receptor (FCGR) dependent phagocytosis
reactomeR-HSA-2029485Role of phospholipids in phagocytosis
reactomeR-HSA-210993Tie2 Signaling
reactomeR-HSA-2172127DAP12 interactions
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in Cancer
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2424491DAP12 signaling
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-2454202Fc epsilon receptor (FCERI) signaling
reactomeR-HSA-2730905Role of LAT2/NTAL/LAB on calcium mobilization
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373753Nephrin family interactions
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-388841Costimulation by the CD28 family
reactomeR-HSA-389356CD28 co-stimulation
reactomeR-HSA-389357CD28 dependent PI3K/Akt signaling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-416482G alpha (12/13) signalling events
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-451927Interleukin-2 family signaling
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-5637810Constitutive Signaling by EGFRvIII
reactomeR-HSA-5637812Signaling by EGFRvIII in Cancer
reactomeR-HSA-5637815Signaling by Ligand-Responsive EGFR Variants in Cancer
reactomeR-HSA-5654687Downstream signaling of activated FGFR1
reactomeR-HSA-5654689PI-3K cascade:FGFR1
reactomeR-HSA-5654695PI-3K cascade:FGFR2
reactomeR-HSA-5654696Downstream signaling of activated FGFR2
reactomeR-HSA-5654708Downstream signaling of activated FGFR3
reactomeR-HSA-5654710PI-3K cascade:FGFR3
reactomeR-HSA-5654716Downstream signaling of activated FGFR4
reactomeR-HSA-5654720PI-3K cascade:FGFR4
reactomeR-HSA-5654736Signaling by FGFR1
reactomeR-HSA-5654738Signaling by FGFR2
reactomeR-HSA-5654741Signaling by FGFR3
reactomeR-HSA-5654743Signaling by FGFR4
reactomeR-HSA-5655253Signaling by FGFR2 in disease
reactomeR-HSA-5655291Signaling by FGFR4 in disease
reactomeR-HSA-5655302Signaling by FGFR1 in disease
reactomeR-HSA-5655332Signaling by FGFR3 in disease
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-6806834Signaling by MET
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-8851907MET activates PI3K/AKT signaling
reactomeR-HSA-8853334Signaling by FGFR3 fusions in cancer
reactomeR-HSA-8853338Signaling by FGFR3 point mutants in cancer
reactomeR-HSA-8853659RET signaling
reactomeR-HSA-9006115Signaling by NTRK2 (TRKB)
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9028335Activated NTRK2 signals through PI3K
reactomeR-HSA-9034015Signaling by NTRK3 (TRKC)
reactomeR-HSA-912526Interleukin receptor SHC signaling
reactomeR-HSA-912631Regulation of signaling by CBL
reactomeR-HSA-912631Regulation of signaling by CBL
reactomeR-HSA-9603381Activated NTRK3 signals through PI3K
biocartaachpathwayrole of nicotinic acetylcholine receptors in the regulation of apoptosis
biocartaaktpathwayakt signaling pathway
biocartaarfpathwaytumor suppressor arf inhibits ribosomal biogenesis
biocartabadpathwayregulation of bad phosphorylation
biocartabcellsurvivalpathwayb cell survival pathway
biocartabiopeptidespathwaybioactive peptide induced signaling pathway
biocartacdc42racpathwayrole of pi3k subunit p85 in regulation of actin organization and cell migration
biocartacrebpathwaytranscription factor creb and its extracellular signals
biocartactcfpathwayctcf: first multivalent nuclear factor
biocartactla4pathwaythe co-stimulatory signal during t-cell activation
biocartacxcr4pathwaycxcr4 signaling pathway
biocartaecmpathwayerk and pi-3 kinase are necessary for collagen binding in corneal epithelia
biocartaedg1pathwayphospholipids as signalling intermediaries
biocartaegfpathwayegf signaling pathway
biocartaeif4pathwayregulation of eif-4e and p70s6 kinase
biocartaerk5pathwayrole of erk5 in neuronal survival pathway
biocartafcer1pathwayfc epsilon receptor i signaling in mast cells
biocartagcrpathwaycorticosteroids and cardioprotection
biocartaghpathwaygrowth hormone signaling pathway
biocartagleevecpathwayinhibition of cellular proliferation by gleevec
biocartagsk3pathwayinactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
biocartahcmvpathwayhuman cytomegalovirus and map kinase pathways
biocartahdacpathwaycontrol of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk)
biocartaher2pathwayrole of erbb2 in signal transduction and oncology
biocartaigf1mtorpathwayskeletal muscle hypertrophy is regulated via akt-mtor pathway
biocartaigf1pathwayigf-1 signaling pathway
biocartaigf1rpathwaymultiple antiapoptotic pathways from igf-1r signaling lead to bad phosphorylation
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
biocartail7pathwayil-7 signal transduction
biocartainsulinpathwayinsulin signaling pathway
biocartalongevitypathwaythe igf-1 receptor and longevity
biocartamtorpathwaymtor signaling pathway
biocartanfatpathwaynfat and hypertrophy of the heart
biocartangfpathwaynerve growth factor pathway (ngf)
biocartankcellspathwayras-independent pathway in nk cell-mediated cytotoxicity
biocartano1pathwayactions of nitric oxide in the heart
biocartapar1pathwaythrombin signaling and protease-activated receptors
biocartapdgfpathwaypdgf signaling pathway
biocartaplcpathwayphospholipase c signaling pathway
biocartaptenpathwaypten dependent cell cycle arrest and apoptosis
biocartarac1pathwayrac1 cell motility signaling pathway
biocartaraccycdpathwayinfluence of ras and rho proteins on g1 to s transition
biocartaraspathwayras signaling pathway
biocartatcrpathwayt cell receptor signaling pathway
biocartatffpathwaytrefoil factors initiate mucosal healing
biocartatpopathwaytpo signaling pathway
biocartatrkapathwaytrka receptor signaling pathway
biocartavegfpathwayvegf hypoxia and angiogenesis
pida6b1_a6b4_integrin_pathwaya6b1 and a6b4 Integrin signaling
pidangiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
pidar_nongenomic_pathwayNongenotropic Androgen signaling
pidavb3_integrin_pathwayIntegrins in angiogenesis
pidavb3_opn_pathwayOsteopontin-mediated events
pidbcr_5pathwayBCR signaling pathway
pidcd40_pathwayCD40/CD40L signaling
pidcdc42_pathwayCDC42 signaling events
pidcxcr3pathwayCXCR3-mediated signaling events
pidcxcr4_pathwayCXCR4-mediated signaling events
pidecadherin_keratinocyte_pathwayE-cadherin signaling in keratinocytes
pidecadherin_nascentaj_pathwayE-cadherin signaling in the nascent adherens junction
pidepha2_fwdpathwayEPHA2 forward signaling
pidephbfwdpathwayEPHB forward signaling
pidephrinbrevpathwayEphrin B reverse signaling
pider_nongenomic_pathwayPlasma membrane estrogen receptor signaling
piderbb1_downstream_pathwayErbB1 downstream signaling
piderbb1_internalization_pathwayInternalization of ErbB1
piderbb2erbb3pathwayErbB2/ErbB3 signaling events
piderbb4_pathwayErbB4 signaling events
pidfak_pathwaySignaling events mediated by focal adhesion kinase
pidfaspathwayFAS (CD95) signaling pathway
pidfcer1pathwayFc-epsilon receptor I signaling in mast cells
pidfgf_pathwayFGF signaling pathway
pidgmcsf_pathwayGMCSF-mediated signaling events
pidhedgehog_2pathwaySignaling events mediated by the Hedgehog family
pidifngpathwayIFN-gamma pathway
pidigf1_pathwayIGF1 pathway
pidil1pathwayIL1-mediated signaling events
pidil23pathwayIL23-mediated signaling events
pidil2_1pathwayIL2-mediated signaling events
pidil2_pi3kpathwayIL2 signaling events mediated by PI3K
pidil2_stat5pathwayIL2 signaling events mediated by STAT5
pidil3_pathwayIL3-mediated signaling events
pidil4_2pathwayIL4-mediated signaling events
pidil5_pathwayIL5-mediated signaling events
pidil6_7pathwayIL6-mediated signaling events
pidinsulin_pathwayInsulin Pathway
pidkitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
pidlymphangiogenesis_pathwayVEGFR3 signaling in lymphatic endothelium
pidmet_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pidncadherinpathwayN-cadherin signaling events
pidnectin_pathwayNectin adhesion pathway
pidnephrin_neph1_pathwayNephrin/Neph1 signaling in the kidney podocyte
pidnetrin_pathwayNetrin-mediated signaling events
pidnfkappabatypicalpathwayAtypical NF-kappaB pathway
pidp75ntrpathwayp75(NTR)-mediated signaling
pidpdgfrapathwayPDGFR-alpha signaling pathway
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidpi3kcipathwayClass I PI3K signaling events
pidpi3kplctrkpathwayTrk receptor signaling mediated by PI3K and PLC-gamma
pidptp1bpathwaySignaling events mediated by PTP1B
pidreelinpathwayReelin signaling pathway
pidret_pathwaySignaling events regulated by Ret tyrosine kinase
pids1p_s1p2_pathwayS1P2 pathway
pidshp2_pathwaySHP2 signaling
pidtcptp_pathwaySignaling events mediated by TCPTP
pidthrombin_par1_pathwayPAR1-mediated thrombin signaling events
pidtrail_pathwayTRAIL signaling pathway
pidtrkrpathwayNeurotrophic factor-mediated Trk receptor signaling
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
pidvegfr1_pathwayVEGFR1 specific signals
pharmgkbPA153627758Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkbPA165959584Sorafenib Pharmacodynamics
smpdbSMP00011Inositol Metabolism
smpdbSMP00320Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdbSMP00321Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
smpdbSMP00358Fc Epsilon Receptor I Signaling in Mast Cells
smpdbSMP00463Phosphatidylinositol Phosphate Metabolism
smpdbSMP00582Joubert syndrome
wikipathwaysWP1403AMP-activated Protein Kinase (AMPK) Signaling
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP1539Angiogenesis
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP1982Sterol Regulatory Element-Binding Proteins (SREBP) signalling
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP2038Regulation of Microtubule Cytoskeleton
wikipathwaysWP2203Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathwaysWP2261Signaling Pathways in Glioblastoma
wikipathwaysWP2263Androgen Receptor Network in Prostate Cancer
wikipathwaysWP2593JAK-STAT
wikipathwaysWP2865IL1 and megakaryocytes in obesity
wikipathwaysWP3Transcriptional activation by NRF2
wikipathwaysWP306Focal Adhesion
wikipathwaysWP313Signaling of Hepatocyte Growth Factor Receptor
wikipathwaysWP3286Copper homeostasis
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP3651Pathways Affected in Adenoid Cystic Carcinoma
wikipathwaysWP3844PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3937Microglia Pathogen Phagocytosis Pathway
wikipathwaysWP395IL-4 Signaling Pathway
wikipathwaysWP3972PDGFR-beta pathway
wikipathwaysWP3981miRNA regulation of prostate cancer signaling pathways
wikipathwaysWP4141PI3K-AKT-mTOR - VitD3 Signalling
wikipathwaysWP4155Endometrial cancer
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4205MET in type 1 papillary renal cell carcinoma
wikipathwaysWP4223Ras Signaling
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP481Insulin Signaling
wikipathwaysWP51Regulation of Actin Cytoskeleton
wikipathwaysWP524G13 Signaling Pathway
wikipathwaysWP710DNA Damage Response (only ATM dependent)
wikipathwaysWP712Estrogen signaling pathway
wikipathwaysWP722Serotonin HTR1 Group and FOS Pathway
wikipathwaysWP75Toll-like Receptor Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD590AZD53634
iGMDRD980PI3K alpha inhibitor3
iGMDRD276AS 6052401
iGMDRD79Gemcitabine3
iGMDRD560MK-22062
iGMDRD352PD-03259011
iGMDRD698Neratinib4
iGMDRD883CIL55A3
iGMDRD879chemotherapy1
iGMDRD123Isoevodiamine7
iGMDRD5Tyrphostin AG 14786
iGMDRD293Bleomycin1
iGMDRD137Indisulam3
iGMDRD121GMX17784
iGMDRD213SMR0000686504
iGMDRD221Tamoxifen2
iGMDRD455Idelalisib1
iGMDRD993QL-XII-611
iGMDRD119Temsirolimus3
iGMDRD367Ro 28-16753
iGMDRD871BRD63682
iGMDRD322FK 8662
iGMDRD552AZD-17752
iGMDRD147Prima-13
iGMDRD889Compound 7d-cis1
iGMDRD749ZINC67184531
iGMDRD433Lexibulin6
iGMDRD409Saracatinib2
iGMDRD483SCH-5290742
iGMDRD397Pazopanib1
iGMDRD670ML 2101
iGMDRD639YK 4-2791
iGMDRD61Kinetin riboside1
iGMDRD748PHA-6657521
iGMDRD470Trametinib1
iGMDRD778SCHEMBL135867081
iGMDRD679Bistramide A1
iGMDRD466Chaetocin1
iGMDRD816anti-EGFR mAbs1
iGMDRD888Compound 444
iGMDRD11Aspirin in adjuvant setting1
iGMDRD982PI3K Inhibitor1
iGMDRD133Lapatinib2
iGMDRD880chemotherapy (HER2 ampl)1
iGMDRD23Gossypol1
iGMDRD512nutlin 36
iGMDRD792Cetuximab10
iGMDRD148Pifithrin-mu1
iGMDRD10Aspirin1
iGMDRD116CD4372
iGMDRD424Tamatinib3
iGMDRD536PLX-47201
iGMDRD57Chloropentafluorobenzene3
iGMDRD435BI-25361
iGMDRD310Everolimus7
iGMDRD807Ado-trastuzumab emtansine2
iGMDRD481Dactolisib4
iGMDRD267Oligomycin A11
iGMDRD6AM-5803
iGMDRD434BMS-5369242
iGMDRD967Panitumumab5
iGMDRD599Salermide3
iGMDRD579PF7506
iGMDRD462OSI-906 (Linsitinib)1
iGMDRD129SB-2167631
iGMDRD638Ribociclib1
iGMDRD986PIK3CA inhibitor3
iGMDRD446LY 21832405
iGMDRD498GW441756X1
iGMDRD280CYTOCHALASIN B7
iGMDRD134Sorafenib1
iGMDRD480KU00606483
iGMDRD138PX 123
iGMDRD30917AAG4
iGMDRD727Alpelisib9
iGMDRD887Compound 23 citrate3
iGMDRD454JNK Inhibitor VIII1
iGMDRD268Cerulenin1
iGMDRD248BRD43541
iGMDRD324CI-10401
iGMDRD564GSK-6503941
iGMDRD523Cyanoquinoline, 114
iGMDRD520Pictilisib5
iGMDRD532Olaparib1
iGMDRD738PP-2421
iGMDRD683Taselisib3
iGMDRD341Triacsin c3
iGMDRD605AZD64822
iGMDRD945ML2148
iGMDRD402AKT Inhibitor VIII4
iGMDRD101Fulvestrant3
iGMDRD705Nakiterpiosin2
iGMDRD105Triptolide7
iGMDRD329Merck602
iGMDRD366PI-1032
iGMDRD286Nsc 6328392
iGMDRD839BRAF inhibitor1
iGMDRD263AACOCF31
iGMDRD118Perifosine2
iGMDRD126Tipifarnib3
iGMDRD571Cabozantinib1
iGMDRD151CHM-11
iGMDRD507GSK6906935
iGMDRD474Avrainvillamide4
iGMDRD996Radiation1
iGMDRD52Rotenone2
iGMDRD983PI3K pathway inhibitor55
iGMDRD284Palbociclib2
iGMDRD171Pemetrexed2
iGMDRD188Piperlongumine4
iGMDRD399Selumetinib2
iGMDRD74Idarubicin1
iGMDRD874BRD89582
iGMDRD524ISX-92
iGMDRD190Nilotinib1
iGMDRD64Parbendazole7
iGMDRD1020Trastuzumab9
iGMDRD486Tosedostat9
iGMDRD456Crizotinib1
iGMDRD345Compound 10b [PMID: 11504634]6
iGMDRD984PI3K pathway inhibitor (alone or in combination)9
iGMDRD592Apitolisib2
iGMDRD901ELCPK1
iGMDRD271Brefeldin A1
iGMDRD459RO-33061
iGMDRD68Paclitaxel1
iGMDRD415LE-1355
iGMDRD414MST-3126
iGMDRD872BRD71379
iGMDRD472PF-5622711
iGMDRD505Pevonedistat1
iGMDRD300Tozasertib1
iGMDRD136Nutlin-31
iGMDRD193Fqi16
iGMDRD671CH51327992
iGMDRD519GDC-09411
iGMDRD5182-(1H-Indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine1
iGMDRD686PF47086711
iGMDRD634SCHEMBL26080411
iGMDRD401Afatinib2
iGMDRD673LSM-12152
iGMDRD255SB2250022
iGMDRD109Gefitinib2
iGMDRD422Regorafenib1
iGMDRD491TAE-6841
iGMDRD318PAC-11
iGMDRD478ABT-8881
iGMDRD441TW 374
iGMDRD782DC-45-A21
iGMDRD586Ridaforolimus1
iGMDRD562Navitoclax2
iGMDRD398Sepantronium1
iGMDRD596Vemurafenib1
iGMDRD60Quinoclamine8
iGMDRD131Erlotinib2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PIK3CA

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