iGMDRD470


Canonical SMILES: CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5

InChI: InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)

InChI Key: LIRYPHYGHXZJBZ-UHFFFAOYSA-N

Standard NameCHEMBLPubchem CIDDRUGBANK IDDrug StatusDrug Type
TrametinibCHEMBL2105741 CHEMBL2103875 11707100DB08911AloneSmall Molecule



Drug Pathways:

ERK MAPK signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
55510DDX431
567B2M1
3845KRAS15
5295PIK3R11
8289ARID1A1
6657SOX21
7428VHL1
2064ERBB21
472ATM1
139285AMER11
898CCNE11
23152CIC1
1029CDKN2A1
5834PYGB1
7157TP531
3673ITGA21
3170FOXA21
5604MAP2K127
4869NPM11
369ARAF1
1848DUSP61
5290PIK3CA1
54894RNF431
1956EGFR1
673BRAF247
2767GNA111
2776GNAQ1
5111PCNA1
5583PRKCH1
4893NRAS6
7403KDM6A1
4763NF114
1499CTNNB11

Gene in drug-gene network: Network Plot

Models in Trametinib

​​​​