iGMDRD470
Canonical SMILES: CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5
InChI: InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
InChI Key: LIRYPHYGHXZJBZ-UHFFFAOYSA-N
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Standard Name | CHEMBL | Pubchem CID | DRUGBANK ID | Drug Status | Drug Type |
|---|---|---|---|---|---|
Standard NameTrametinib CHEMBLCHEMBL2105741 CHEMBL2103875 Pubchem CID11707100 DRUGBANK IDDB08911 Drug StatusAlone Drug TypeSmall Molecule | |||||
Drug Class:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsCytochrome P-450 Enzyme InducersCytochrome P-450 Enzyme InhibitorsEnzyme InhibitorsHeterocyclic CompoundsHeterocyclic Compounds, 1-RingKinase InhibitorMAP Kinase Kinase 1, antagonists & inhibitorsMAP Kinase Kinase 2, antagonists & inhibitorsProtein Kinase InhibitorsPyridinesPyrimidinesDrug Pathways:
ERK MAPK signalingDrug-model tissue-cancer distribution: Bubble Plot
Drug-gene pathway enrichments
Drug-gene GO enrichments
Drug-Gene: Aster Plot
Gene in drug-gene network: Network Plot
Models in Trametinib
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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