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ARID1A

Summary: This gene encodes a member of the SWI/SNF family, whose members have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has a DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
AT-rich interaction domain 1A	MIM:603024	Ensembl:ENSG00000117713	HGNC:HGNC:11110	PA35960	1p36.11

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in ARID1A

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IEA	GO:0001704	formation of primary germ layer
BP	IEA	GO:0001843	neural tube closure
BP	IEA	GO:0003205	cardiac chamber development
BP	IEA	GO:0003408	optic cup formation involved in camera-type eye development
BP	IDA	GO:0006337	nucleosome disassembly
BP	IDA	GO:0006338	chromatin remodeling
BP	IEA	GO:0006344	maintenance of chromatin silencing
BP	IEA	GO:0006351	transcription, DNA-templated
BP	NAS	GO:0006357	regulation of transcription by RNA polymerase II
BP	IEA	GO:0007566	embryo implantation
BP	IEA	GO:0019827	stem cell population maintenance
BP	IDA	GO:0030520	intracellular estrogen receptor signaling pathway
BP	IDA	GO:0030521	androgen receptor signaling pathway
BP	IEA	GO:0030900	forebrain development
BP	TAS	GO:0042766	nucleosome mobilization
BP	IDA	GO:0042921	glucocorticoid receptor signaling pathway
BP	IEA	GO:0043044	ATP-dependent chromatin remodeling
BP	IDA	GO:0045893	positive regulation of transcription, DNA-templated
BP	TAS	GO:0048096	chromatin-mediated maintenance of transcription
BP	IEA	GO:0055007	cardiac muscle cell differentiation
BP	IEA	GO:0060674	placenta blood vessel development
BP	HEP	GO:0071277	cellular response to calcium ion
BP	IEA	GO:1901998	toxin transport
CC	IDA	GO:0000790	nuclear chromatin
CC	TAS	GO:0005634	nucleus
CC	IDA	GO:0005654	nucleoplasm
CC	IDA	GO:0016514	SWI/SNF complex
CC	ISS	GO:0071564	npBAF complex
CC	ISS	GO:0071565	nBAF complex
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IDA	GO:0003677	DNA binding
MF	NAS	GO:0003677	DNA binding
MF	NAS	GO:0003713	transcription coactivator activity
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0016922	nuclear receptor binding
MF	IEA	GO:0031491	nucleosome binding

Gene expression in normal tissue: ARID1A

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ARID1A

Database	Pathway ID	Pathway Des.
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-3214858	RMTs methylate histone arginines
reactome	R-HSA-3247509	Chromatin modifying enzymes
reactome	R-HSA-4839726	Chromatin organization
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-8878171	Transcriptional regulation by RUNX1
reactome	R-HSA-8939243	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
biocarta	hswisnfpathway	chromatin remodeling by hswi/snf atp-dependent complexes
biocarta	pcafpathway	the information processing pathway at the ifn beta enhancer
kegg	hsa04714	Thermogenesis - Homo sapiens (human)
kegg	hsa05225	Hepatocellular carcinoma - Homo sapiens (human)
wikipathways	WP2002	miR-targeted genes in epithelium - TarBase
wikipathways	WP2004	miR-targeted genes in lymphocytes - TarBase
wikipathways	WP2005	miR-targeted genes in muscle cell - TarBase
wikipathways	WP2263	Androgen Receptor Network in Prostate Cancer
wikipathways	WP3651	Pathways Affected in Adenoid Cystic Carcinoma
wikipathways	WP4204	Tumor suppressor activity of SMARCB1

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD1021	Trastuzumab (ANXA1 high)	1
iGMDRD286	Nsc 632839	8
iGMDRD329	Merck60	2
iGMDRD263	AACOCF3	3
iGMDRD245	FH535	1
iGMDRD402	AKT Inhibitor VIII	2
iGMDRD289	Parthenolide	3
iGMDRD705	Nakiterpiosin	2
iGMDRD396	AS601245	1
iGMDRD461	VX-11e	2
iGMDRD341	Triacsin c	2
iGMDRD945	ML214	2
iGMDRD605	AZD6482	1
iGMDRD48	Dexamethasone	2
iGMDRD370	TPCA-1	1
iGMDRD150	RITA	2
iGMDRD1036	X17AAG	1
iGMDRD523	Cyanoquinoline, 11	2
iGMDRD399	Selumetinib	1
iGMDRD188	Piperlongumine	4
iGMDRD506	Fedratinib	6
iGMDRD369	TGX-115	2
iGMDRD64	Parbendazole	2
iGMDRD474	Avrainvillamide	4
iGMDRD171	Pemetrexed	2
iGMDRD117	Docetaxel	1
iGMDRD593	CX-5461	1
iGMDRD52	Rotenone	2
iGMDRD152	179324-69-7	2
iGMDRD394	BX-795	2
iGMDRD151	CHM-1	2
iGMDRD126	Tipifarnib	7
iGMDRD420	Leucascandrolide A	5
iGMDRD427	ABT737	2
iGMDRD872	BRD7137	7
iGMDRD1015	THZ-2-102-1	1
iGMDRD414	MST-312	2
iGMDRD505	Pevonedistat	6
iGMDRD300	Tozasertib	3
iGMDRD503	CMK	1
iGMDRD901	ELCPK	2
iGMDRD486	Tosedostat	2
iGMDRD1020	Trastuzumab	2
iGMDRD345	Compound 10b [PMID: 11504634]	1
iGMDRD577	BIX01294	2
iGMDRD60	Quinoclamine	4
iGMDRD131	Erlotinib	1
iGMDRD255	SB225002	3
iGMDRD907	EZH2 inhibitor	2
iGMDRD758	JW-7-24-1	1
iGMDRD573	GSK-1904529A	1
iGMDRD885	Compound 110	2
iGMDRD318	PAC-1	1
iGMDRD193	Fqi1	2
iGMDRD401	Afatinib	2
iGMDRD348	BMS-345541	1
iGMDRD54	Phenformin	1
iGMDRD772	BRD4770	2
iGMDRD678	Tubastatin A	1
iGMDRD971	PARP inhibitor	2
iGMDRD871	BRD6368	6
iGMDRD322	FK 866	3
iGMDRD534	BRD1429	1
iGMDRD137	Indisulam	2
iGMDRD158	NSC141540	4
iGMDRD121	GMX1778	6
iGMDRD202	Curcumin	3
iGMDRD5	Tyrphostin AG 1478	5
iGMDRD221	Tamoxifen	4
iGMDRD215	CCT007093	1
iGMDRD77	Itraconazole	5
iGMDRD219	Bax channel blocker	2
iGMDRD237	ABT-751	2
iGMDRD698	Neratinib	4
iGMDRD123	Isoevodiamine	2
iGMDRD154	NSC23766	2
iGMDRD883	CIL55A	1
iGMDRD1002	rTRAIL	2
iGMDRD475	BX 912	1
iGMDRD392	Masitinib	1
iGMDRD719	IOX2	1
iGMDRD560	MK-2206	3
iGMDRD79	Gemcitabine	5
iGMDRD730	Kahalalide F	3
iGMDRD23	Gossypol	2
iGMDRD260	FQI-2	2
iGMDRD568	SCHEMBL15005512	1
iGMDRD187	BRD9876	3
iGMDRD226	ML006	2
iGMDRD326	Belinostat (PXD101)	1
iGMDRD61	Kinetin riboside	5
iGMDRD639	YK 4-279	2
iGMDRD466	Chaetocin	1
iGMDRD470	Trametinib	1
iGMDRD409	Saracatinib	1
iGMDRD433	Lexibulin	4
iGMDRD12	Bicalutamide	1
iGMDRD889	Compound 7d-cis	2
iGMDRD546	BMS-754807	4
iGMDRD476	WH-4-023	1
iGMDRD483	SCH-529074	4
iGMDRD269	Purmorphamine	2
iGMDRD246	NPC26	3
iGMDRD191	FMK	1
iGMDRD42	Vorinostat	3
iGMDRD267	Oligomycin A	3
iGMDRD231	Importazole	3
iGMDRD481	Dactolisib	3
iGMDRD57	Chloropentafluorobenzene	4
iGMDRD177	Teniposide	5
iGMDRD84	Lovastatin acid	2
iGMDRD424	Tamatinib	2
iGMDRD116	CD437	2
iGMDRD652	UNC0638	1
iGMDRD100	Zebularine	2
iGMDRD692	SB590885	1
iGMDRD451	Serdemetan	4
iGMDRD268	Cerulenin	1
iGMDRD454	JNK Inhibitor VIII	1
iGMDRD270	Ciclosporin	2
iGMDRD802	4-methylfasudil	1
iGMDRD440	Nutlin-3A	1
iGMDRD498	GW441756X	2
iGMDRD446	LY 2183240	3
iGMDRD908	EZH2 inhibitor in RAS wt	1
iGMDRD280	CYTOCHALASIN B	1
iGMDRD375	GW-405833	2
iGMDRD599	Salermide	2
iGMDRD144	NSC95397	7
iGMDRD462	OSI-906 (Linsitinib)	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARID1A

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.