FOXA2
Summary: This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| forkhead box A2 | MIM:600288 | Ensembl:ENSG00000125798 | HGNC:HGNC:5022 | PA201091 | 20p11.21 |
GO terms in FOXA2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0030054 | cell junction |
| BP | ISS | GO:0000432 | positive regulation of transcription from RNA polymerase II promoter by glucose |
| BP | ISS | GO:0001708 | cell fate specification |
| BP | IEA | GO:0006325 | chromatin organization |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0008344 | adult locomotory behavior |
| BP | IBA | GO:0009653 | anatomical structure morphogenesis |
| BP | IMP | GO:0010719 | negative regulation of epithelial to mesenchymal transition |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IDA | GO:0030193 | regulation of blood coagulation |
| BP | IDA | GO:0031018 | endocrine pancreas development |
| BP | ISS | GO:0033132 | negative regulation of glucokinase activity |
| BP | ISS | GO:0040019 | positive regulation of embryonic development |
| BP | IMP | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | ISS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0061178 | regulation of insulin secretion involved in cellular response to glucose stimulus |
| BP | ISS | GO:0061987 | negative regulation of transcription from RNA polymerase II promoter by glucose |
| BP | TAS | GO:0070741 | response to interleukin-6 |
| BP | IGI | GO:0071542 | dopaminergic neuron differentiation |
| BP | ISS | GO:0071542 | dopaminergic neuron differentiation |
| BP | TAS | GO:0071542 | dopaminergic neuron differentiation |
| BP | ISS | GO:0090009 | primitive streak formation |
| BP | IC | GO:2000049 | positive regulation of cell-cell adhesion mediated by cadherin |
| BP | ISS | GO:2000543 | positive regulation of gastrulation |
| BP | ISS | GO:2000971 | negative regulation of detection of glucose |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IEA | GO:0008134 | transcription factor binding |
| MF | IEA | GO:0019904 | protein domain specific binding |
| MF | IMP | GO:0044212 | transcription regulatory region DNA binding |
Gene expression in normal tissue: FOXA2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FOXA2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-186712 | Regulation of beta-cell development |
| reactome | R-HSA-210745 | Regulation of gene expression in beta cells |
| pid | hedgehog_glipathway | Hedgehog signaling events mediated by Gli proteins |
| pid | hnf3apathway | FOXA1 transcription factor network |
| pid | hnf3bpathway | FOXA2 and FOXA3 transcription factor networks |
| kegg | hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| kegg | hsa04950 | Maturity onset diabetes of the young - Homo sapiens (human) |
| wikipathways | WP1591 | Heart Development |
| wikipathways | WP2406 | Cardiac Progenitor Differentiation |
| wikipathways | WP2853 | Endoderm Differentiation |
| wikipathways | WP2855 | Dopaminergic Neurogenesis |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP2858 | Ectoderm Differentiation |
| wikipathways | WP4010 | Liver steatosis AOP |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD686 | PF4708671 | 1 |
| iGMDRD402 | AKT Inhibitor VIII | 1 |
| iGMDRD470 | Trametinib | 1 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD476 | WH-4-023 | 1 |
| iGMDRD129 | SB-216763 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FOXA2
CLASSFICATION
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