iGMDRD402


Canonical SMILES: C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=NC6=CC7=C(C=C6N=C5C8=CC=CC=C8)N=CN7

InChI: InChI=1S/C34H29N7O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33/h1-13,18-19,21,25H,14-17,20H2,(H,35,36)(H,39,42)

InChI Key: BIWGYFZAEWGBAL-UHFFFAOYSA-N

Standard NameCHEMBLPubchem CIDDrug StatusDrug Type
AKT Inhibitor VIIICHEMBL3819449 CHEMBL258844 10196500AloneSmall Molecule

Drug Targets:

AKT1AKT2AKT3

Drug Pathways:

PI3K/MTOR signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
3845KRAS2
5295PIK3R12
8289ARID1A2
6597SMARCA41
2033EP3001
207AKT17
2064ERBB22
472ATM1
1029CDKN2A3
7157TP532
3170FOXA21
6794STK111
2263FGFR21
57111RAB251
5290PIK3CA4
675BRCA21
1956EGFR1
3553IL1B1
10000AKT31
5728PTEN3
171023ASXL11
8821INPP4B1
5291PIK3CB4
100862685ERVK-191
55193PBRM11

Gene in drug-gene network: Network Plot

Models in AKT Inhibitor VIII

​​​​