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iGMDRD402

Canonical SMILES: C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=NC6=CC7=C(C=C6N=C5C8=CC=CC=C8)N=CN7

InChI: InChI=1S/C34H29N7O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33/h1-13,18-19,21,25H,14-17,20H2,(H,35,36)(H,39,42)

InChI Key: BIWGYFZAEWGBAL-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	Drug Status	Drug Type
AKT Inhibitor VIII	CHEMBL3819449 CHEMBL258844	10196500	Alone	Small Molecule

Drug Targets:

AKT1 AKT2 AKT3

Drug Pathways:

PI3K/MTOR signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
3845	KRAS	2
5295	PIK3R1	2
8289	ARID1A	2
6597	SMARCA4	1
2033	EP300	1
207	AKT1	7
2064	ERBB2	2
472	ATM	1
1029	CDKN2A	3
7157	TP53	2
3170	FOXA2	1
6794	STK11	1
2263	FGFR2	1
57111	RAB25	1
5290	PIK3CA	4
675	BRCA2	1
1956	EGFR	1
3553	IL1B	1
10000	AKT3	1
5728	PTEN	3
171023	ASXL1	1
8821	INPP4B	1
5291	PIK3CB	4
100862685	ERVK-19	1
55193	PBRM1	1

Gene in drug-gene network: Network Plot

Models in AKT Inhibitor VIII

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Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.