PBRM1
Summary: This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namepolybromo 1 OMIM IDMIM:606083 Ensembl IDEnsembl:ENSG00000163939 HGNC IDHGNC:HGNC:30064 PHARMGKB IDPA162398846 Map Location3p21.1 | |||||
Gene Categories:
CLINICALLY ACTIONABLEGO terms in PBRM1
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | NAS | GO:0003682 | chromatin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0015616 | DNA translocase activity |
| BP | TAS | GO:0000278 | mitotic cell cycle |
Gene expression in normal tissue: PBRM1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PBRM1
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3214858 | RMTs methylate histone arginines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PBRM1
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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