PBRM1


Summary: This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:606083
PHARMGKB IDPA162398846
Map Location3p21.1

Gene Categories:

CLINICALLY ACTIONABLE

GO terms in PBRM1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0003677 DNA binding
MF IBA GO:0003682 chromatin binding
MF NAS GO:0003682 chromatin binding
MF IPI GO:0005515 protein binding
MF IBA GO:0015616 DNA translocase activity
BP TAS GO:0000278 mitotic cell cycle
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Gene expression in normal tissue: PBRM1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 3BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: Colorectal Adenocarcinoma (COADREAD) model num: 1HEAD_NECtissue: HEAD_NEC cancer: HEAD_NECK model num: 0HEAD_NECKtissue: HEAD_NECK cancer: Head and Neck Squamous Cell Carcinoma (HNSC) model num: 5KIDNEtissue: KIDNE cancer: KIDNEY model num: 0KIDNEYtissue: KIDNEY cancer: Renal Clear Cell Carcinoma (CCRCC) model num: 4KIDNEYtissue: KIDNEY cancer: Renal Cell Carcinoma (RCC) model num: 1PANCREAtissue: PANCREA cancer: PANCREAS model num: 0PANCREAStissue: PANCREAS cancer: Pancreatic Adenocarcinoma (PAAD) model num: 2OTHEtissue: OTHE cancer: OTHER model num: 0OTHERtissue: OTHER cancer: Cancer of Unknown Primary (CUP) model num: 3

Gene-drug pathway distribution

undefined3Cell cycle2ERK MAPK signaling2RTK signaling2IGFR signaling1WNT signaling1EGFR signaling1JNK and p38 signaling1Other, kinases1DNA replication1

Pathways in PBRM1


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Database
Pathway ID
Pathway Des.
kegg hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
wikipathways WP4018 Pathways in clear cell renal cell carcinoma
reactome R-HSA-212436 Generic Transcription Pathway
reactome R-HSA-3214858 RMTs methylate histone arginines
reactome R-HSA-3247509 Chromatin modifying enzymes
reactome R-HSA-4839726 Chromatin organization
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD293 Bleomycin 1
iGMDRD310 Everolimus 1
iGMDRD907 EZH2 inhibitor 2
iGMDRD467 Motesanib 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PBRM1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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