PBRM1
Summary: This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| polybromo 1 | MIM:606083 | Ensembl:ENSG00000163939 | HGNC:HGNC:30064 | PA162398846 | 3p21.1 |
Gene Categories:
CLINICALLY ACTIONABLEGO terms in PBRM1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | NAS | GO:0003682 | chromatin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0015616 | DNA translocase activity |
| BP | TAS | GO:0000278 | mitotic cell cycle |
| BP | IBA | GO:0006337 | nucleosome disassembly |
| BP | TAS | GO:0006338 | chromatin remodeling |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IBA | GO:0006368 | transcription elongation from RNA polymerase II promoter |
| BP | IMP | GO:0008285 | negative regulation of cell proliferation |
| BP | IBA | GO:0043044 | ATP-dependent chromatin remodeling |
| CC | NAS | GO:0000228 | nuclear chromosome |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0016586 | RSC-type complex |
| CC | IEA | GO:0016586 | RSC-type complex |
Gene expression in normal tissue: PBRM1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PBRM1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3214858 | RMTs methylate histone arginines |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939243 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD293 | Bleomycin | 1 |
| iGMDRD310 | Everolimus | 1 |
| iGMDRD907 | EZH2 inhibitor | 2 |
| iGMDRD467 | Motesanib | 1 |
| iGMDRD402 | AKT Inhibitor VIII | 1 |
| iGMDRD429 | Amuvatinib | 1 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD454 | JNK Inhibitor VIII | 1 |
| iGMDRD792 | Cetuximab | 1 |
| iGMDRD462 | OSI-906 (Linsitinib) | 1 |
| iGMDRD498 | GW441756X | 2 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD908 | EZH2 inhibitor in RAS wt | 1 |
| iGMDRD435 | BI-2536 | 1 |
| iGMDRD218 | XAV 939 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PBRM1
CLASSFICATION
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