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iGMDRD467

Canonical SMILES: CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C

InChI: InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)

InChI Key: RAHBGWKEPAQNFF-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	Drug Status	Drug Type
Motesanib	CHEMBL572881 CHEMBL2107357	11667900	Alone	Small Molecule

Drug Targets:

VEGFR RET c-KIT PDGFR

Drug Pathways:

RTK signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
103	ADAR	1
8266	UBL4A	1
25937	WWTR1	1
7428	VHL	1
983	CDK1	1
6850	SYK	1
10018	BCL2L11	1
3932	LCK	1
7157	TP53	1
6794	STK11	1
3791	KDR	1
8731	RNMT	1
1956	EGFR	1
5156	PDGFRA	1
1938	EEF2	1
2113	ETS1	1
5979	RET	2
1027	CDKN1B	1
29994	BAZ2B	1
23380	SRGAP2	1
3815	KIT	1
142	PARP1	1
581	BAX	1
55193	PBRM1	1

Gene in drug-gene network: Network Plot

Models in Motesanib

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.