PDGFRA
Summary: This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| platelet derived growth factor receptor alpha | MIM:173490 | Ensembl:ENSG00000134853 | HGNC:HGNC:8803 | PA33147 | 4q12 |
GO terms in PDGFRA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | ISS | GO:0001553 | luteinization |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | TAS | GO:0001775 | cell activation |
| BP | IEA | GO:0002244 | hematopoietic progenitor cell differentiation |
| BP | IMP | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0008210 | estrogen metabolic process |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IBA | GO:0009968 | negative regulation of signal transduction |
| BP | IDA | GO:0010544 | negative regulation of platelet activation |
| BP | IMP | GO:0010863 | positive regulation of phospholipase C activity |
| BP | TAS | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| BP | IEA | GO:0016032 | viral process |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0023019 | signal transduction involved in regulation of gene expression |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0030198 | extracellular matrix organization |
| BP | IEA | GO:0030324 | lung development |
| BP | IEA | GO:0030325 | adrenal gland development |
| BP | IDA | GO:0030335 | positive regulation of cell migration |
| BP | IMP | GO:0030335 | positive regulation of cell migration |
| BP | IEA | GO:0030539 | male genitalia development |
| BP | IEA | GO:0033327 | Leydig cell differentiation |
| BP | IBA | GO:0033674 | positive regulation of kinase activity |
| BP | IDA | GO:0034614 | cellular response to reactive oxygen species |
| BP | IMP | GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway |
| BP | IDA | GO:0038091 | positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway |
| BP | ISS | GO:0042060 | wound healing |
| BP | IEA | GO:0042475 | odontogenesis of dentin-containing tooth |
| BP | IBA | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IMP | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IDA | GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| BP | IMP | GO:0048015 | phosphatidylinositol-mediated signaling |
| BP | IDA | GO:0048146 | positive regulation of fibroblast proliferation |
| BP | ISS | GO:0048557 | embryonic digestive tract morphogenesis |
| BP | IBA | GO:0048701 | embryonic cranial skeleton morphogenesis |
| BP | ISS | GO:0048701 | embryonic cranial skeleton morphogenesis |
| BP | ISS | GO:0048704 | embryonic skeletal system morphogenesis |
| BP | IMP | GO:0050920 | regulation of chemotaxis |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | ISS | GO:0055003 | cardiac myofibril assembly |
| BP | IEA | GO:0060021 | roof of mouth development |
| BP | IEA | GO:0060325 | face morphogenesis |
| BP | IMP | GO:0060326 | cell chemotaxis |
| BP | ISS | GO:0061298 | retina vasculature development in camera-type eye |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0070527 | platelet aggregation |
| BP | IEA | GO:0071230 | cellular response to amino acid stimulus |
| BP | ISS | GO:0072277 | metanephric glomerular capillary formation |
| BP | TAS | GO:2000249 | regulation of actin cytoskeleton reorganization |
| BP | IMP | GO:2000739 | regulation of mesenchymal stem cell differentiation |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0005902 | microvillus |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0030054 | cell junction |
| CC | IDA | GO:0031226 | intrinsic component of plasma membrane |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IBA | GO:0043235 | receptor complex |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004709 | MAP kinase kinase kinase activity |
| MF | IBA | GO:0004713 | protein tyrosine kinase activity |
| MF | IBA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IDA | GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| MF | IBA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IBA | GO:0005018 | platelet-derived growth factor alpha-receptor activity |
| MF | IDA | GO:0005018 | platelet-derived growth factor alpha-receptor activity |
| MF | IMP | GO:0005018 | platelet-derived growth factor alpha-receptor activity |
| MF | IDA | GO:0005021 | vascular endothelial growth factor-activated receptor activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IPI | GO:0005161 | platelet-derived growth factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0019838 | growth factor binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | IPI | GO:0038085 | vascular endothelial growth factor binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0044877 | protein-containing complex binding |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| MF | IBA | GO:0048407 | platelet-derived growth factor binding |
| MF | IDA | GO:0048407 | platelet-derived growth factor binding |
| MF | IPI | GO:0048407 | platelet-derived growth factor binding |
Gene expression in normal tissue: PDGFRA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDGFRA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP2406 | Cardiac Progenitor Differentiation |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP322 | Osteoblast Signaling |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
| wikipathways | WP3640 | Imatinib and Chronic Myeloid Leukemia |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP3980 | Protein alkylation leading to liver fibrosis |
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4223 | Ras Signaling |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| pid | atf2_pathway | ATF-2 transcription factor network |
| pid | pdgf_pathway | PDGF receptor signaling network |
| pid | pdgfrapathway | PDGFR-alpha signaling pathway |
| pharmgkb | PA165980050 | Vemurafenib Pathway, Pharmacodynamics |
| pharmgkb | PA165980050 | update your name in edit mode |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05218 | Melanoma - Homo sapiens (human) |
| kegg | hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| biocarta | cdc42racpathway | role of pi3k subunit p85 in regulation of actin organization and cell migration |
| biocarta | edg1pathway | phospholipids as signalling intermediaries |
| biocarta | pdgfpathway | pdgf signaling pathway |
| biocarta | rac1pathway | rac1 cell motility signaling pathway |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-186763 | Downstream signal transduction |
| reactome | R-HSA-186797 | Signaling by PDGF |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD536 | PLX-4720 | 1 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 1 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD307 | Manumycin A | 2 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD3 | PD-173074 | 1 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD415 | LE-135 | 2 |
| iGMDRD551 | Ponatinib | 1 |
| iGMDRD6 | AM-580 | 4 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD241 | Sunitinib | 10 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD136 | Nutlin-3 | 1 |
| iGMDRD313 | Axitinib | 1 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD239 | Dasatinib | 4 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD413 | Crenolanib | 16 |
| iGMDRD134 | Sorafenib | 1 |
| iGMDRD270 | Ciclosporin | 3 |
| iGMDRD422 | Regorafenib | 5 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD314 | Tanespimycin | 5 |
| iGMDRD352 | PD-0325901 | 1 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD976 | PDGFR inhibitor | 2 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD467 | Motesanib | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD202 | Curcumin | 2 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD152 | 179324-69-7 | 4 |
| iGMDRD425 | ERASTIN | 2 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD427 | ABT737 | 9 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD41 | Imatinib | 120 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD190 | Nilotinib | 1 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD920 | HSP90 inhibitor | 2 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 6 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD284 | Palbociclib | 1 |
| iGMDRD171 | Pemetrexed | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDGFRA
CLASSFICATION
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