PDGFRA
Summary: This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:173490 Ensembl IDEnsembl:ENSG00000134853 HGNC IDHGNC:HGNC:8803 PHARMGKB IDPA33147 Map Location4q12 | |||||
GO terms in PDGFRA
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | ISS | GO:0001553 | luteinization |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | TAS | GO:0001775 | cell activation |
| BP | IEA | GO:0002244 | hematopoietic progenitor cell differentiation |
| BP | IMP | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
Gene expression in normal tissue: PDGFRA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDGFRA
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP2406 | Cardiac Progenitor Differentiation |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP322 | Osteoblast Signaling |
| wikipathways | WP3611 | Photodynamic therapy-induced AP-1 survival signaling. |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDGFRA
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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