CDK1
Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:116940 Ensembl IDEnsembl:ENSG00000170312 HGNC IDHGNC:HGNC:1722 PHARMGKB IDPA99 Map Location10q21.2 |
GO terms in CDK1
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | IDA | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex |
CC | HDA | GO:0000784 | nuclear chromosome, telomeric region |
CC | IBA | GO:0005634 | nucleus |
CC | IDA | GO:0005634 | nucleus |
CC | TAS | GO:0005654 | nucleoplasm |
CC | IBA | GO:0005737 | cytoplasm |
Gene expression in normal tissue: CDK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDK1
Database | Pathway ID | Pathway Des. |
---|---|---|
biocarta | akap95pathway | akap95 role in mitosis and chromosome dynamics |
biocarta | akapcentrosomepathway | protein kinase a at the centrosome |
biocarta | cdc25pathway | cdc25 and chk1 regulatory pathway in response to dna damage |
biocarta | cellcyclepathway | cyclins and cell cycle regulation |
biocarta | efppathway | estrogen responsive protein efp controls cell cycle and breast tumors growth |
biocarta | g1pathway | cell cycle: g1/s check point |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in CDK1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |