CDK1
Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin dependent kinase 1 | MIM:116940 | Ensembl:ENSG00000170312 | HGNC:HGNC:1722 | PA99 | 10q21.2 |
GO terms in CDK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex |
| CC | HDA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005759 | mitochondrial matrix |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005876 | spindle microtubule |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0030496 | midbody |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IBA | GO:0072686 | mitotic spindle |
| CC | IDA | GO:0072686 | mitotic spindle |
| CC | IMP | GO:0097125 | cyclin B1-CDK1 complex |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | IBA | GO:0000226 | microtubule cytoskeleton organization |
| BP | TAS | GO:0000226 | microtubule cytoskeleton organization |
| BP | TAS | GO:0006260 | DNA replication |
| BP | TAS | GO:0006281 | DNA repair |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| BP | TAS | GO:0007077 | mitotic nuclear envelope disassembly |
| BP | IEA | GO:0007095 | mitotic G2 DNA damage checkpoint |
| BP | TAS | GO:0007098 | centrosome cycle |
| BP | TAS | GO:0007344 | pronuclear fusion |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IEA | GO:0007569 | cell aging |
| BP | IEA | GO:0008283 | cell proliferation |
| BP | TAS | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
| BP | IBA | GO:0010468 | regulation of gene expression |
| BP | IEA | GO:0010628 | positive regulation of gene expression |
| BP | IMP | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0014038 | regulation of Schwann cell differentiation |
| BP | IEA | GO:0014070 | response to organic cyclic compound |
| BP | IEA | GO:0014075 | response to amine |
| BP | IEA | GO:0014823 | response to activity |
| BP | TAS | GO:0016477 | cell migration |
| BP | IEA | GO:0016572 | histone phosphorylation |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0030261 | chromosome condensation |
| BP | IEP | GO:0030855 | epithelial cell differentiation |
| BP | IEA | GO:0031100 | animal organ regeneration |
| BP | TAS | GO:0031145 | anaphase-promoting complex-dependent catabolic process |
| BP | IEA | GO:0033160 | positive regulation of protein import into nucleus, translocation |
| BP | IDA | GO:0034501 | protein localization to kinetochore |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | IBA | GO:0044772 | mitotic cell cycle phase transition |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IEA | GO:0045740 | positive regulation of DNA replication |
| BP | TAS | GO:0045995 | regulation of embryonic development |
| BP | IEA | GO:0046686 | response to cadmium ion |
| BP | IEA | GO:0046688 | response to copper ion |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | IEA | GO:0048678 | response to axon injury |
| BP | IEA | GO:0051301 | cell division |
| BP | IEA | GO:0055015 | ventricular cardiac muscle cell development |
| BP | IEA | GO:0060045 | positive regulation of cardiac muscle cell proliferation |
| BP | IEA | GO:0065003 | protein-containing complex assembly |
| BP | IEA | GO:0070301 | cellular response to hydrogen peroxide |
| BP | ISS | GO:0090166 | Golgi disassembly |
| BP | TAS | GO:0097711 | ciliary basal body-plasma membrane docking |
| BP | IMP | GO:1900182 | positive regulation of protein localization to nucleus |
| BP | IMP | GO:1905448 | positive regulation of mitochondrial ATP synthesis coupled electron transport |
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IEA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IDA | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IMP | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | TAS | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity |
| MF | IDA | GO:0030332 | cyclin binding |
| MF | IPI | GO:0030332 | cyclin binding |
| MF | IEA | GO:0030544 | Hsp70 protein binding |
| MF | IDA | GO:0035173 | histone kinase activity |
| MF | IDA | GO:0097472 | cyclin-dependent protein kinase activity |
Gene expression in normal tissue: CDK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | akap95pathway | akap95 role in mitosis and chromosome dynamics |
| biocarta | akapcentrosomepathway | protein kinase a at the centrosome |
| biocarta | cdc25pathway | cdc25 and chk1 regulatory pathway in response to dna damage |
| biocarta | cellcyclepathway | cyclins and cell cycle regulation |
| biocarta | efppathway | estrogen responsive protein efp controls cell cycle and breast tumors growth |
| biocarta | g1pathway | cell cycle: g1/s check point |
| biocarta | g2pathway | cell cycle: g2/m checkpoint |
| biocarta | mprpathway | how progesterone initiates the oocyte maturation |
| biocarta | plk3pathway | regulation of cell cycle progression by plk3 |
| biocarta | ptc1pathway | sonic hedgehog receptor ptc1 regulates cell cycle |
| biocarta | rbpathway | rb tumor suppressor/checkpoint signaling in response to dna damage |
| biocarta | sam68pathway | regulation of splicing through sam68 |
| biocarta | stathminpathway | stathmin and breast cancer resistance to antimicrotubule agents |
| reactome | R-HSA-110056 | MAPK3 (ERK1) activation |
| reactome | R-HSA-112409 | RAF-independent MAPK1/3 activation |
| reactome | R-HSA-113507 | E2F-enabled inhibition of pre-replication complex formation |
| reactome | R-HSA-113510 | E2F mediated regulation of DNA replication |
| reactome | R-HSA-1362300 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 |
| reactome | R-HSA-1538133 | G0 and Early G1 |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162658 | Golgi Cisternae Pericentriolar Stack Reorganization |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-170145 | Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes |
| reactome | R-HSA-174048 | APC/C:Cdc20 mediated degradation of Cyclin B |
| reactome | R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins |
| reactome | R-HSA-174184 | Cdc20:Phospho-APC/C mediated degradation of Cyclin A |
| reactome | R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase |
| reactome | R-HSA-176409 | APC/C:Cdc20 mediated degradation of mitotic proteins |
| reactome | R-HSA-176412 | Phosphorylation of the APC/C |
| reactome | R-HSA-176417 | Phosphorylation of Emi1 |
| reactome | R-HSA-176814 | Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins |
| reactome | R-HSA-179419 | APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2299718 | Condensation of Prophase Chromosomes |
| reactome | R-HSA-2465910 | MASTL Facilitates Mitotic Progression |
| reactome | R-HSA-2500257 | Resolution of Sister Chromatid Cohesion |
| reactome | R-HSA-2514853 | Condensation of Prometaphase Chromosomes |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-2980766 | Nuclear Envelope Breakdown |
| reactome | R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 |
| reactome | R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-380259 | Loss of Nlp from mitotic centrosomes |
| reactome | R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes |
| reactome | R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome |
| reactome | R-HSA-380287 | Centrosome maturation |
| reactome | R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4419969 | Depolymerisation of the Nuclear Lamina |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453276 | Regulation of mitotic cell cycle |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-539107 | Activation of E2F1 target genes at G1/S |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620912 | Anchoring of the basal body to the plasma membrane |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-5687128 | MAPK6/MAPK4 signaling |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689896 | Ovarian tumor domain proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes |
| reactome | R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest |
| reactome | R-HSA-6804757 | Regulation of TP53 Degradation |
| reactome | R-HSA-6806003 | Regulation of TP53 Expression and Degradation |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69205 | G1/S-Specific Transcription |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition |
| reactome | R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69473 | G2/M DNA damage checkpoint |
| reactome | R-HSA-69478 | G2/M DNA replication checkpoint |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-75035 | Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex |
| reactome | R-HSA-8852276 | The role of GTSE1 in G2/M progression after G2 checkpoint |
| reactome | R-HSA-8854518 | AURKA Activation by TPX2 |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP1858 | Mitotic G1-G1-S phases |
| wikipathways | WP2038 | Regulation of Microtubule Cytoskeleton |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP2516 | ATM Signaling Pathway |
| wikipathways | WP2878 | PPAR Alpha Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3878 | ATM Signaling Network in Development and Disease |
| wikipathways | WP45 | G1 to S cell cycle control |
| wikipathways | WP707 | DNA Damage Response |
| pid | ap1_pathway | AP-1 transcription factor network |
| pid | e2f_pathway | E2F transcription factor network |
| pid | foxm1pathway | FOXM1 transcription factor network |
| pid | p73pathway | p73 transcription factor network |
| pid | plk1_pathway | PLK1 signaling events |
| pid | retinoic_acid_pathway | Retinoic acid receptors-mediated signaling |
| pharmgkb | PA165374494 | Busulfan Pathway, Pharmacodynamics |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_TCR | TCR |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD311 | Dacinostat | 1 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD615 | BRD-K02251932 | 1 |
| iGMDRD467 | Motesanib | 1 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD658 | CHEMBL1673039 | 1 |
| iGMDRD150 | RITA | 1 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD564 | GSK-650394 | 1 |
| iGMDRD346 | Nintedanib | 1 |
| iGMDRD184 | IPA-3 | 1 |
| iGMDRD167 | BMS614 | 1 |
| iGMDRD540 | Alisertib | 1 |
| iGMDRD452 | PF-573228 | 1 |
| iGMDRD647 | StemRegenin 1 | 1 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD848 | BRD-K28456706 | 1 |
| iGMDRD491 | TAE-684 | 1 |
| iGMDRD94 | Narciclasine | 1 |
| iGMDRD598 | QS-11 | 1 |
| iGMDRD268 | Cerulenin | 1 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD185 | DMOG | 1 |
| iGMDRD391 | OSU-03012 | 1 |
| iGMDRD398 | Sepantronium | 1 |
| iGMDRD403 | BAY 61-3606 | 1 |
| iGMDRD587 | CHEMBL585951 | 1 |
| iGMDRD112 | Methotrexate | 1 |
| iGMDRD12 | Bicalutamide | 1 |
| iGMDRD401 | Afatinib | 1 |
| iGMDRD661 | UNC-0321 | 1 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD66 | Doxorubicin | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDK1
CLASSFICATION
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