CDK1


Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:116940
PHARMGKB IDPA99
Map Location10q21.2

GO terms in CDK1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0000307 cyclin-dependent protein kinase holoenzyme complex
CC HDA GO:0000784 nuclear chromosome, telomeric region
CC IBA GO:0005634 nucleus
CC IDA GO:0005634 nucleus
CC TAS GO:0005654 nucleoplasm
CC IBA GO:0005737 cytoplasm
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Gene expression in normal tissue: CDK1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 51SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: undefined model num: 2

Gene-drug pathway distribution

undefined22RTK signaling2Apoptosis regulation2Chromatin histone acetylation2DNA replication2Bile secretion1Prostate cancer1EGFR signaling1JNK and p38 signaling1Metabolism1

Pathways in CDK1


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Database
Pathway ID
Pathway Des.
biocarta akap95pathway akap95 role in mitosis and chromosome dynamics
biocarta akapcentrosomepathway protein kinase a at the centrosome
biocarta cdc25pathway cdc25 and chk1 regulatory pathway in response to dna damage
biocarta cellcyclepathway cyclins and cell cycle regulation
biocarta efppathway estrogen responsive protein efp controls cell cycle and breast tumors growth
biocarta g1pathway cell cycle: g1/s check point
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD434 BMS-536924 3
iGMDRD311 Dacinostat 1
iGMDRD158 NSC141540 1
iGMDRD615 BRD-K02251932 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CDK1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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