SRGAP2
Summary: This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606524 Ensembl IDEnsembl:ENSG00000266028 HGNC IDHGNC:HGNC:19751 PHARMGKB IDPA164742513 Map Location1q32.1 | |||||
GO terms in SRGAP2
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0003363 | lamellipodium assembly involved in ameboidal cell migration |
| BP | IEA | GO:0007165 | signal transduction |
| BP | IMP | GO:0008283 | cell proliferation |
| BP | ISS | GO:0021816 | extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration |
| BP | IBA | GO:0030336 | negative regulation of cell migration |
| BP | IMP | GO:0034446 | substrate adhesion-dependent cell spreading |
Gene expression in normal tissue: SRGAP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SRGAP2
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194840 | Rho GTPase cycle |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-376176 | Signaling by ROBO receptors |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SRGAP2
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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