iGMDRD748

Canonical SMILES: CC1=C(NC(=C1C(=O)N2CCCC2CN3CCCC3)C)C=C4C5=C(C=CC(=C5)S(=O)(=O)CC6=C(C=CC=C6Cl)Cl)NC4=O

InChI: InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/t21-/m1/s1

InChI Key: OYONTEXKYJZFHA-OAQYLSRUSA-N

Standard NamePubchem CIDDrug StatusDrug Type
PHA-66575266596700AloneSmall Molecule

Drug Class:

Kinase inhibitor

Drug Targets:

MET

Drug Pathways:

RTK signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
55697VAC141
106480060RNU6-1123P1
56893UBQLN42
100505621C11orf721
9468PCYT1B1
347918EP400P11
10054UBA21
902CCNH1
91653BOC1
92521SPECC11
7272TTK1
3845KRAS1
5295PIK3R11
25913POT11
101927862CTB-178M22.21
254158CXorf581
1993ELAVL21
5547PRCP1
6597SMARCA41
4036LRP21
645676ASH1L-AS11
4771NF21
255231MCOLN21
164045HFM11
117143TADA12
140469MYO3B1
1387CREBBP1
467ATF31
29074MRPL181
392138OR2A252
8242KDM5C1
191AHCY1
6892TAPBP1
79839CCDC102B1
9024BRSK21
3107HLA-C2
55294FBXW71
4610MYCL1
27065NSG11
11321GPN11
106481161RNU6ATAC8P2
4300MLLT32
124245ZC3H181
5451POU2F11
8826IQGAP11
108ADCY21
8790FPGT1
101928770LINC015261
3106HLA-B1
2064ERBB22
166793ZBTB491
149428BNIPL1
102466191MIR67361
150946GAREM21
122748OR11H61
23394ADNP1
399806LBX1-AS11
112609MRAP21
27344PCSK1N1
406978MIR199B1
1360CPB11
1029CDKN2A1
100861555LINC005652
8776MTMR11
64108RTP42
7157TP532
6794STK111
83650SLC35G52
4292MLH11
101929402EXTL3-AS11
641516KC61
107075197MTCO2P332
387978LINC015511
57102C12orf42
58512DLGAP31
10500SEMA6C1
144715RAD9B1
1104RCC11
677837SNORA601
5650KLK71
23779ARHGAP81
2835GPR121
4089SMAD41
54472TOLLIP1
102465505MIR68391
9252RPS6KA52
275AMT1
103695363FOXG1-AS11
5290PIK3CA1
1173AP2M11
4025LPO1
744MPPED21
4609MYC1
3208HPCA1
1031CDKN2C1
106479749RNU6-414P1
145873MESP21
5152PDE9A1
673BRAF1
106480076RNU6-1158P1
11248NXPH31
57599WDR481
6392SDHD1
83932SPRTN1
8626TP631
6861SYT51
284207METRNL1
157739TDH1
284739C20orf2041
652170COX4I1P21
285987DLX6-AS11
81610FAM83D1
106481932RNU6-1051P2
5728PTEN1
5636PRPSAP21
9788MTSS11
54550NECAB21
8065CUL51
80896NPL1
4931NVL1
1375CPT1B1
293SLC25A61
114769CARD162
440253WHAMMP21
596BCL21
22876INPP5F1
100151686RNU6ATAC3P1
84059ADGRV11
101927957LINC015721
390445OR5AU11
162494RHBDL31
6492SIM11
90187EMILIN31
407022MIR2961
80852GRIP21
9148NEURL11
55007FAM118A1
23380SRGAP21
10549PRDX41
126669SHE1
100873801RNY4P232
406954MIR181A21
9543IGDCC31
106479682RNU6-260P2
5925RB11
4893NRAS2
55251PCMTD21
7403KDM6A1
285ANGPT21
100616320MIR44811
79290OR13A11
693134MIR550A21
157381LINC009641
595CCND11
51062ATL11
4763NF11
4613MYCN2
65975STK331
5339PLEC1
100129794SLC25A21-AS11
4277MICB2
101954267RNVU1-152
100506574SNRPGP91
84457PHYHIPL1
1499CTNNB11
284040CDRT41
7538ZFP361
5624PROC1
128ADH51

Gene in drug-gene network: Network Plot

Models in PHA-665752

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