BOC
Summary: The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BOC cell adhesion associated, oncogene regulated | MIM:608708 | Ensembl:ENSG00000144857 | HGNC:HGNC:17173 | PA143485316 | 3q13.2 |
Gene Categories:
DRUGGABLE GENOMEGO terms in BOC
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005887 | integral component of plasma membrane |
| CC | IEA | GO:0044295 | axonal growth cone |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | IEA | GO:0007224 | smoothened signaling pathway |
| BP | IEA | GO:0007411 | axon guidance |
| BP | ISS | GO:0045663 | positive regulation of myoblast differentiation |
| BP | TAS | GO:0051149 | positive regulation of muscle cell differentiation |
Gene expression in normal tissue: BOC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BOC
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04340 | Hedgehog signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| pid | hedgehog_2pathway | Signaling events mediated by the Hedgehog family |
| wikipathways | WP2858 | Ectoderm Differentiation |
| wikipathways | WP3313 | Hedgehog ,on, state |
| wikipathways | WP4249 | Hedgehog Signaling Pathway |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-375170 | CDO in myogenesis |
| reactome | R-HSA-375170 | CDO in myogenesis |
| reactome | R-HSA-525793 | Myogenesis |
| reactome | R-HSA-525793 | Myogenesis |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5358351 | Signaling by Hedgehog |
| reactome | R-HSA-5632681 | Ligand-receptor interactions |
| reactome | R-HSA-5632684 | Hedgehog 'on' state |
| reactome | R-HSA-5632684 | Hedgehog 'on' state |
| reactome | R-HSA-5635838 | Activation of SMO |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD748 | PHA-665752 | 1 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD353 | PD0325901 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BOC
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.