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BOC

Summary: The protein encoded by this gene is a member of the immunoglobulin/fibronectin type III repeat family. It is a component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells, and promotes myogenic differentiation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameBOC cell adhesion associated, oncogene regulated OMIM IDMIM:608708 Ensembl IDEnsembl:ENSG00000144857 HGNC IDHGNC:HGNC:17173 PHARMGKB IDPA143485316 Map Location3q13.2

Gene Categories:

DRUGGABLE GENOME

GO terms in BOC

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IPI	GO:0005515	protein binding
CC	IDA	GO:0005654	nucleoplasm
CC	TAS	GO:0005886	plasma membrane
CC	IEA	GO:0005887	integral component of plasma membrane
CC	IEA	GO:0044295	axonal growth cone
BP	IEA	GO:0007155	cell adhesion

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Gene expression in normal tissue: BOC

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BOC

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Database	Pathway ID	Pathway Des.
kegg	hsa04340	Hedgehog signaling pathway - Homo sapiens (human)
kegg	hsa04360	Axon guidance - Homo sapiens (human)
pid	hedgehog_2pathway	Signaling events mediated by the Hedgehog family
wikipathways	WP2858	Ectoderm Differentiation
wikipathways	WP3313	Hedgehog ,on, state
wikipathways	WP4249	Hedgehog Signaling Pathway

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD748	PHA-665752	1
iGMDRD309	17AAG	1
iGMDRD353	PD0325901	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BOC

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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