LPO
Summary: This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
Namelactoperoxidase OMIM IDMIM:150205 Ensembl IDEnsembl:ENSG00000167419 HGNC IDHGNC:HGNC:6678 PHARMGKB IDPA30439 Map Location17q22 |
Gene Categories:
DRUGGABLE GENOMEGO terms in LPO
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IBA | GO:0004601 | peroxidase activity |
MF | IEA | GO:0020037 | heme binding |
MF | IBA | GO:0036393 | thiocyanate peroxidase activity |
MF | IDA | GO:0036393 | thiocyanate peroxidase activity |
MF | IEA | GO:0046872 | metal ion binding |
BP | IDA | GO:0001580 | detection of chemical stimulus involved in sensory perception of bitter taste |
Gene expression in normal tissue: LPO
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LPO
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Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa04970 | Salivary secretion - Homo sapiens (human) |
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Gene-Drug: Aster Plot
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Drug ID | Drug Name | Model Num. |
---|---|---|
iGMDRD748 | PHA-665752 | 1 |
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in LPO
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |