LPO


Summary: This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:150205
PHARMGKB IDPA30439
Map Location17q22

Gene Categories:

DRUGGABLE GENOME

GO terms in LPO


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004601 peroxidase activity
MF IEA GO:0020037 heme binding
MF IBA GO:0036393 thiocyanate peroxidase activity
MF IDA GO:0036393 thiocyanate peroxidase activity
MF IEA GO:0046872 metal ion binding
BP IDA GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
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Gene expression in normal tissue: LPO

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LPO


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Database
Pathway ID
Pathway Des.
kegg hsa04970 Salivary secretion - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD748 PHA-665752 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LPO

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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