TTK
Summary: This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:604092 Ensembl IDEnsembl:ENSG00000112742 HGNC IDHGNC:HGNC:12401 PHARMGKB IDPA37066 Map Location6q14.1 | |||||
GO terms in TTK
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0007051 | spindle organization |
| BP | TAS | GO:0007052 | mitotic spindle organization |
| BP | TAS | GO:0007094 | mitotic spindle assembly checkpoint |
| BP | TAS | GO:0008284 | positive regulation of cell proliferation |
| BP | TAS | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| BP | IEA | GO:0016321 | female meiosis chromosome segregation |
Gene expression in normal tissue: TTK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TTK
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TTK
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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