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iGMDRD506

Canonical SMILES: CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4

InChI: InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)

InChI Key: JOOXLOJCABQBSG-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Fedratinib	CHEMBL1287853	16722800	DB12500	Alone	Small Molecule

Drug Class:

Amides Heterocyclic Compounds Heterocyclic Compounds, 1-Ring Sulfones Sulfur Compounds

Drug Targets:

JAK2

Drug Pathways:

Other, kinases

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
331	XIAP	3
3696	ITGB8	6
64901	RANBP17	6
4854	NOTCH3	3
6664	SOX11	3
7074	TIAM1	2
5027	P2RX7	2
997	CDC34	3
7837	PXDN	1
1464	CSPG4	2
23085	ERC1	4
7128	TNFAIP3	6
21	ABCA3	3
6581	SLC22A3	1
132	ADK	3
6774	STAT3	2
5933	RBL1	3
6195	RPS6KA1	3
8915	BCL10	2
6319	SCD	3
8476	CDC42BPA	2
11183	MAP4K5	8
29101	SSU72	1
4291	MLF1	1
2986	GUCY2F	4
2048	EPHB2	3
79947	DHDDS	6
10806	SDCCAG8	2
23513	SCRIB	3
7171	TPM4	6
10783	NEK6	1
1969	EPHA2	2
9149	DYRK1B	2
7272	TTK	2
347365	ITIH6	1
3845	KRAS	2
1138	CHRNA5	4
4750	NEK1	3
8289	ARID1A	6
137994	LETM2	1
701	BUB1B	7
8573	CASK	5
84700	MYO18B	5
5593	PRKG2	1
53616	ADAM22	6
4352	MPL	4
1263	PLK3	1
9263	STK17A	1
3551	IKBKB	2
8780	RIOK3	6
7764	ZNF217	5
11160	ERLIN2	2
353345	GPR141	6
11116	FGFR1OP	2
10320	IKZF1	5
3209	HOXA13	3
7444	VRK2	1
10892	MALT1	6
23235	SIK2	2
10863	ADAM28	2
4170	MCL1	1
1607	DGKB	1
22853	LMTK2	2
2241	FER	5
55534	MAML3	5
341676	NEK5	1
1404	HAPLN1	3
6318	SERPINB4	3
9816	URB2	4
4092	SMAD7	1
84299	MIEN1	10
1545	CYP1B1	3
55252	ASXL2	1
51199	NIN	3
577	ADGRB3	1
114783	LMTK3	2
202374	STK32A	3
1387	CREBBP	5
9232	PTTG1	4
8844	KSR1	5
1859	DYRK1A	1
2313	FLI1	2
10013	HDAC6	1
11200	CHEK2	1
31	ACACA	1
7133	TNFRSF1B	3
10178	TENM1	5
57472	CNOT6	3
1111	CHEK1	2
2977	GUCY1A2	4
10438	C1D	2
11122	PTPRT	2
3456	IFNB1	1
5159	PDGFRB	3
51512	GTSE1	3
55294	FBXW7	4
974	CD79B	3
2033	EP300	6
8784	TNFRSF18	3
9578	CDC42BPB	2
5914	RARA	9
1021	CDK6	1
23522	KAT6B	3
55728	N4BP2	2
3227	HOXC11	1
10006	ABI1	3
102	ADAM10	1
57670	KIAA1549	4
837	CASP4	1
4301	AFDN	2
5081	PAX7	1
342667	STAC2	8
5607	MAP2K5	2
57396	CLK4	1
1540	CYLD	3
57787	MARK4	2
8549	LGR5	3
3714	JAG2	3
8852	AKAP4	4
329	BIRC2	6
64083	GOLPH3	6
22806	IKZF3	6
2242	FES	5
10342	TFG	3
1437	CSF2	2
8313	AXIN2	3
6733	SRPK2	2
2042	EPHA3	3
1050	CEBPA	5
51343	FZR1	2
23255	MTCL1	2
114548	NLRP3	4
5984	RFC4	3
4216	MAP3K4	5
10298	PAK4	2
29904	EEF2K	4
597	BCL2A1	1
695	BTK	2
4194	MDM4	3
1984	EIF5A	3
7088	TLE1	2
269	AMHR2	2
83931	STK40	2
2045	EPHA7	2
1992	SERPINB1	13
7016	TESK1	1
1277	COL1A1	4
171019	ADAMTS19	7
22858	ICK	2
2064	ERBB2	11
94103	ORMDL3	8
85443	DCLK3	2
65266	WNK4	4
6850	SYK	3
57476	GRAMD1B	2
83983	TSSK6	1
8643	PTCH2	3
8395	PIP5K1B	6
834	CASP1	3
55361	PI4K2A	1
23387	SIK3	3
4294	MAP3K10	1
1456	CSNK1G3	2
783	CACNB2	5
9759	HDAC4	3
7525	YES1	3
29760	BLNK	1
10400	PEMT	3
219970	GLYATL2	3
158056	MAMDC4	5
10087	COL4A3BP	6
6793	STK10	3
50488	MINK1	2
2068	ERCC2	1
5591	PRKDC	5
8859	STK19	3
4046	LSP1	3
9472	AKAP6	2
157285	PRAG1	3
8515	ITGA10	6
124923	SGK494	1
2778	GNAS	4
130497	OSR1	1
3685	ITGAV	4
472	ATM	2
2580	GAK	5
5165	PDK3	3
139285	AMER1	5
3397	ID1	2
4087	SMAD2	3
4058	LTK	7
54986	ULK4	2
7010	TEK	4
5289	PIK3C3	1
91461	PKDCC	4
898	CCNE1	7
2050	EPHB4	7
2272	FHIT	11
2066	ERBB4	1
7681	MKRN3	1
8798	DYRK4	1
839	CASP6	3
904	CCNT1	1
5327	PLAT	8
56648	EIF5A2	3
10413	YAP1	3
1029	CDKN2A	5
5108	PCM1	3
139728	PNCK	2
9794	MAML1	3
57523	NYNRIN	2
83694	RPS6KL1	3
3236	HOXD10	3
9874	TLK1	4
11143	KAT7	6
8743	TNFSF10	3
5834	PYGB	1
6092	ROBO2	2
7704	ZBTB16	3
27086	FOXP1	3
4855	NOTCH4	2
4296	MAP3K11	2
4857	NOVA1	4
25836	NIPBL	7
8218	CLTCL1	7
5910	RAP1GDS1	6
3791	KDR	6
10114	HIPK3	3
6772	STAT1	1
93210	PGAP3	6
84513	PLPP5	9
2263	FGFR2	3
8408	ULK1	2
1019	CDK4	1
11213	IRAK3	1
9967	THRAP3	4
1045	CDX2	2
85481	PSKH2	6
8833	GMPS	1
863	CBFA2T3	3
8874	ARHGEF7	3
51086	TNNI3K	2
5597	MAPK6	2
9088	PKMYT1	3
23043	TNIK	5
8660	IRS2	6
3572	IL6ST	4
5077	PAX3	3
9965	FGF19	4
6197	RPS6KA3	2
57188	ADAMTSL3	1
55589	BMP2K	2
65125	WNK1	10
136332	LRGUK	2
4436	MSH2	2
652	BMP4	2
676	BRDT	1
1656	DDX6	2
984	CDK11B	2
1441	CSF3R	1
7175	TPR	4
5871	MAP4K2	12
9401	RECQL4	1
54106	TLR9	3
23365	ARHGEF12	2
84181	CHD6	6
57578	UNC79	3
4437	MSH3	3
2071	ERCC3	1
23269	MGA	3
7994	KAT6A	3
6280	S100A9	2
5610	EIF2AK2	1
5371	PML	8
23469	PHF3	8
170692	ADAMTS18	5
672	BRCA1	10
2668	GDNF	4
10948	STARD3	13
1848	DUSP6	2
4139	MARK1	1
7204	TRIO	6
256536	TCERG1L	2
9252	RPS6KA5	3
10733	PLK4	3
139760	GPR119	3
23373	CRTC1	5
5727	PTCH1	3
9448	MAP4K4	3
285220	EPHA6	1
546	ATRX	2
51366	UBR5	3
5606	MAP2K3	7
5297	PI4KA	1
2047	EPHB1	8
5069	PAPPA	4
10926	DBF4	3
10769	PLK2	3
4958	OMD	3
30827	CXXC1	1
56997	COQ8A	6
340533	NEXMIF	3
5578	PRKCA	1
3702	ITK	2
602	BCL3	1
9972	NUP153	5
3239	HOXD13	3
2187	FANCB	1
84823	LMNB2	6
3720	JARID2	3
4145	MATK	4
4293	MAP3K9	6
26524	LATS2	2
85366	MYLK2	6
2318	FLNC	2
64919	BCL11B	3
57154	SMURF1	2
5530	PPP3CA	3
607	BCL9	1
7075	TIE1	3
1956	EGFR	1
2735	GLI1	2
3065	HDAC1	3
4609	MYC	1
11064	CNTRL	2
64750	SMURF2	4
3308	HSPA4	9
1459	CSNK2A2	4
8682	PEA15	1
5753	PTK6	1
26278	SACS	2
1440	CSF3	9
79759	ZNF668	2
2189	FANCG	1
3635	INPP5D	1
8900	CCNA1	6
7917	BAG6	2
10000	AKT3	2
91754	NEK9	4
93627	TBCK	6
27330	RPS6KA6	3
3949	LDLR	1
10186	LHFPL6	1
6872	TAF1	3
7153	TOP2A	4
1213	CLTC	2
4790	NFKB1	3
6011	GRK1	5
1769	DNAH8	3
5781	PTPN11	3
22976	PAXIP1	1
780	DDR1	3
339345	NANOS2	2
2867	FFAR2	5
6095	RORA	8
29844	TFPT	6
146057	TTBK2	4
84441	MAML2	3
7301	TYRO3	3
7468	NSD2	6
8029	CUBN	3
11184	MAP4K1	4
9113	LATS1	2
460	ASTN1	1
5294	PIK3CG	1
1024	CDK8	3
9451	EIF2AK3	2
2017	CTTN	5
9843	HEPH	3
664	BNIP3	4
51555	PEX5L	3
162968	ZNF497	3
266747	RGL4	2
23049	SMG1	3
10010	TANK	2
55521	TRIM36	3
10752	CHL1	1
5728	PTEN	2
208	AKT2	6
1487	CTBP1	1
51592	TRIM33	3
140609	NEK7	1
4914	NTRK1	3
23281	MTUS2	4
4004	LMO1	6
284086	NEK8	1
23542	MAPK8IP2	6
352909	DNAAF3	4
4317	MMP8	5
6146	RPL22	1
2324	FLT4	1
890	CCNA2	3
9135	RABEP1	1
57139	RGL3	3
28954	REM1	2
91807	MYLK3	9
79834	PEAK1	1
5582	PRKCG	2
7454	WAS	6
10257	ABCC4	5
23389	MED13L	1
203447	NRK	2
23411	SIRT1	2
53904	MYO3A	2
387	RHOA	5
29941	PKN3	3
79012	CAMKV	2
3161	HMMR	5
10249	GLYAT	2
1027	CDKN1B	1
8821	INPP4B	2
9943	OXSR1	6
3627	CXCL10	3
1643	DDB2	2
344905	ATP13A5	8
4297	KMT2A	2
51151	SLC45A2	3
5291	PIK3CB	4
1493	CTLA4	2
10076	PTPRU	8
3985	LIMK2	3
5581	PRKCE	5
2690	GHR	5
2317	FLNB	2
5395	PMS2	2
860	RUNX2	3
53353	LRP1B	1
3181	HNRNPA2B1	7
5609	MAP2K7	4
63976	PRDM16	2
2049	EPHB3	1
283455	KSR2	3
6093	ROCK1	2
5335	PLCG1	3
2130	EWSR1	2
2194	FASN	8
1385	CREB1	4
598	BCL2L1	5
3579	CXCR2	1
5587	PRKD1	1
55007	FAM118A	2
5589	PRKCSH	1
57448	BIRC6	1
3717	JAK2	1
23139	MAST2	4
2157	F8	1
5506	PPP1R3A	2
79837	PIP4K2C	2
3709	ITPR2	5
4221	MEN1	3
8899	PRPF4B	2
4067	LYN	3
23301	EHBP1	3
1030	CDKN2B	3
3984	LIMK1	2
8428	STK24	5
6777	STAT5B	1
5932	RBBP8	3
3977	LIFR	2
5915	RARB	4
4261	CIITA	3
3656	IRAK2	2
4330	MN1	3
23512	SUZ12	3
444	ASPH	5
2122	MECOM	5
5087	PBX1	5
9894	TELO2	6
2903	GRIN2A	1
5925	RB1	4
4217	MAP3K5	3
1515	CTSV	5
4893	NRAS	6
1026	CDKN1A	8
7403	KDM6A	1
7508	XPC	6
112268437	LOC112268437	2
8841	HDAC3	2
4302	MLLT6	6
7040	TGFB1	5
30849	PIK3R4	1
3488	IGFBP5	1
2011	MARK2	2
79728	PALB2	8
23092	ARHGAP26	3
51135	IRAK4	4
10494	STK25	3
2261	FGFR3	3
139604	MAGEB16	3
3237	HOXD11	1
5567	PRKACB	2
8711	TNK1	3
55422	ZNF331	2
3092	HIP1	4
4763	NF1	2
5260	PHKG1	3
6662	SOX9	1
440270	GOLGA8B	2
94	ACVRL1	3
2280	FKBP1A	3
3679	ITGA7	3
10048	RANBP9	5
699	BUB1	2
27255	CNTN6	3
83732	RIOK1	3
4916	NTRK3	5
2886	GRB7	9
1795	DOCK3	1
4486	MST1R	1

Gene in drug-gene network: Network Plot

Models in Fedratinib

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.