iGMDRD506


Canonical SMILES: CC1=CN=C(N=C1NC2=CC(=CC=C2)S(=O)(=O)NC(C)(C)C)NC3=CC=C(C=C3)OCCN4CCCC4

InChI: InChI=1S/C27H36N6O3S/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34,35)32-27(2,3)4/h7-13,18-19,32H,5-6,14-17H2,1-4H3,(H2,28,29,30,31)

InChI Key: JOOXLOJCABQBSG-UHFFFAOYSA-N

Standard NameCHEMBLPubchem CIDDRUGBANK IDDrug StatusDrug Type
FedratinibCHEMBL1287853 16722800DB12500AloneSmall Molecule


Drug Targets:

JAK2

Drug Pathways:

Other, kinases

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
331XIAP3
3696ITGB86
64901RANBP176
4854NOTCH33
6664SOX113
7074TIAM12
5027P2RX72
997CDC343
7837PXDN1
1464CSPG42
23085ERC14
7128TNFAIP36
21ABCA33
6581SLC22A31
132ADK3
6774STAT32
5933RBL13
6195RPS6KA13
8915BCL102
6319SCD3
8476CDC42BPA2
11183MAP4K58
29101SSU721
4291MLF11
2986GUCY2F4
2048EPHB23
79947DHDDS6
10806SDCCAG82
23513SCRIB3
7171TPM46
10783NEK61
1969EPHA22
9149DYRK1B2
7272TTK2
347365ITIH61
3845KRAS2
1138CHRNA54
4750NEK13
8289ARID1A6
137994LETM21
701BUB1B7
8573CASK5
84700MYO18B5
5593PRKG21
53616ADAM226
4352MPL4
1263PLK31
9263STK17A1
3551IKBKB2
8780RIOK36
7764ZNF2175
11160ERLIN22
353345GPR1416
11116FGFR1OP2
10320IKZF15
3209HOXA133
7444VRK21
10892MALT16
23235SIK22
10863ADAM282
4170MCL11
1607DGKB1
22853LMTK22
2241FER5
55534MAML35
341676NEK51
1404HAPLN13
6318SERPINB43
9816URB24
4092SMAD71
84299MIEN110
1545CYP1B13
55252ASXL21
51199NIN3
577ADGRB31
114783LMTK32
202374STK32A3
1387CREBBP5
9232PTTG14
8844KSR15
1859DYRK1A1
2313FLI12
10013HDAC61
11200CHEK21
31ACACA1
7133TNFRSF1B3
10178TENM15
57472CNOT63
1111CHEK12
2977GUCY1A24
10438C1D2
11122PTPRT2
3456IFNB11
5159PDGFRB3
51512GTSE13
55294FBXW74
974CD79B3
2033EP3006
8784TNFRSF183
9578CDC42BPB2
5914RARA9
1021CDK61
23522KAT6B3
55728N4BP22
3227HOXC111
10006ABI13
102ADAM101
57670KIAA15494
837CASP41
4301AFDN2
5081PAX71
342667STAC28
5607MAP2K52
57396CLK41
1540CYLD3
57787MARK42
8549LGR53
3714JAG23
8852AKAP44
329BIRC26
64083GOLPH36
22806IKZF36
2242FES5
10342TFG3
1437CSF22
8313AXIN23
6733SRPK22
2042EPHA33
1050CEBPA5
51343FZR12
23255MTCL12
114548NLRP34
5984RFC43
4216MAP3K45
10298PAK42
29904EEF2K4
597BCL2A11
695BTK2
4194MDM43
1984EIF5A3
7088TLE12
269AMHR22
83931STK402
2045EPHA72
1992SERPINB113
7016TESK11
1277COL1A14
171019ADAMTS197
22858ICK2
2064ERBB211
94103ORMDL38
85443DCLK32
65266WNK44
6850SYK3
57476GRAMD1B2
83983TSSK61
8643PTCH23
8395PIP5K1B6
834CASP13
55361PI4K2A1
23387SIK33
4294MAP3K101
1456CSNK1G32
783CACNB25
9759HDAC43
7525YES13
29760BLNK1
10400PEMT3
219970GLYATL23
158056MAMDC45
10087COL4A3BP6
6793STK103
50488MINK12
2068ERCC21
5591PRKDC5
8859STK193
4046LSP13
9472AKAP62
157285PRAG13
8515ITGA106
124923SGK4941
2778GNAS4
130497OSR11
3685ITGAV4
472ATM2
2580GAK5
5165PDK33
139285AMER15
3397ID12
4087SMAD23
4058LTK7
54986ULK42
7010TEK4
5289PIK3C31
91461PKDCC4
898CCNE17
2050EPHB47
2272FHIT11
2066ERBB41
7681MKRN31
8798DYRK41
839CASP63
904CCNT11
5327PLAT8
56648EIF5A23
10413YAP13
1029CDKN2A5
5108PCM13
139728PNCK2
9794MAML13
57523NYNRIN2
83694RPS6KL13
3236HOXD103
9874TLK14
11143KAT76
8743TNFSF103
5834PYGB1
6092ROBO22
7704ZBTB163
27086FOXP13
4855NOTCH42
4296MAP3K112
4857NOVA14
25836NIPBL7
8218CLTCL17
5910RAP1GDS16
3791KDR6
10114HIPK33
6772STAT11
93210PGAP36
84513PLPP59
2263FGFR23
8408ULK12
1019CDK41
11213IRAK31
9967THRAP34
1045CDX22
85481PSKH26
8833GMPS1
863CBFA2T33
8874ARHGEF73
51086TNNI3K2
5597MAPK62
9088PKMYT13
23043TNIK5
8660IRS26
3572IL6ST4
5077PAX33
9965FGF194
6197RPS6KA32
57188ADAMTSL31
55589BMP2K2
65125WNK110
136332LRGUK2
4436MSH22
652BMP42
676BRDT1
1656DDX62
984CDK11B2
1441CSF3R1
7175TPR4
5871MAP4K212
9401RECQL41
54106TLR93
23365ARHGEF122
84181CHD66
57578UNC793
4437MSH33
2071ERCC31
23269MGA3
7994KAT6A3
6280S100A92
5610EIF2AK21
5371PML8
23469PHF38
170692ADAMTS185
672BRCA110
2668GDNF4
10948STARD313
1848DUSP62
4139MARK11
7204TRIO6
256536TCERG1L2
9252RPS6KA53
10733PLK43
139760GPR1193
23373CRTC15
5727PTCH13
9448MAP4K43
285220EPHA61
546ATRX2
51366UBR53
5606MAP2K37
5297PI4KA1
2047EPHB18
5069PAPPA4
10926DBF43
10769PLK23
4958OMD3
30827CXXC11
56997COQ8A6
340533NEXMIF3
5578PRKCA1
3702ITK2
602BCL31
9972NUP1535
3239HOXD133
2187FANCB1
84823LMNB26
3720JARID23
4145MATK4
4293MAP3K96
26524LATS22
85366MYLK26
2318FLNC2
64919BCL11B3
57154SMURF12
5530PPP3CA3
607BCL91
7075TIE13
1956EGFR1
2735GLI12
3065HDAC13
4609MYC1
11064CNTRL2
64750SMURF24
3308HSPA49
1459CSNK2A24
8682PEA151
5753PTK61
26278SACS2
1440CSF39
79759ZNF6682
2189FANCG1
3635INPP5D1
8900CCNA16
7917BAG62
10000AKT32
91754NEK94
93627TBCK6
27330RPS6KA63
3949LDLR1
10186LHFPL61
6872TAF13
7153TOP2A4
1213CLTC2
4790NFKB13
6011GRK15
1769DNAH83
5781PTPN113
22976PAXIP11
780DDR13
339345NANOS22
2867FFAR25
6095RORA8
29844TFPT6
146057TTBK24
84441MAML23
7301TYRO33
7468NSD26
8029CUBN3
11184MAP4K14
9113LATS12
460ASTN11
5294PIK3CG1
1024CDK83
9451EIF2AK32
2017CTTN5
9843HEPH3
664BNIP34
51555PEX5L3
162968ZNF4973
266747RGL42
23049SMG13
10010TANK2
55521TRIM363
10752CHL11
5728PTEN2
208AKT26
1487CTBP11
51592TRIM333
140609NEK71
4914NTRK13
23281MTUS24
4004LMO16
284086NEK81
23542MAPK8IP26
352909DNAAF34
4317MMP85
6146RPL221
2324FLT41
890CCNA23
9135RABEP11
57139RGL33
28954REM12
91807MYLK39
79834PEAK11
5582PRKCG2
7454WAS6
10257ABCC45
23389MED13L1
203447NRK2
23411SIRT12
53904MYO3A2
387RHOA5
29941PKN33
79012CAMKV2
3161HMMR5
10249GLYAT2
1027CDKN1B1
8821INPP4B2
9943OXSR16
3627CXCL103
1643DDB22
344905ATP13A58
4297KMT2A2
51151SLC45A23
5291PIK3CB4
1493CTLA42
10076PTPRU8
3985LIMK23
5581PRKCE5
2690GHR5
2317FLNB2
5395PMS22
860RUNX23
53353LRP1B1
3181HNRNPA2B17
5609MAP2K74
63976PRDM162
2049EPHB31
283455KSR23
6093ROCK12
5335PLCG13
2130EWSR12
2194FASN8
1385CREB14
598BCL2L15
3579CXCR21
5587PRKD11
55007FAM118A2
5589PRKCSH1
57448BIRC61
3717JAK21
23139MAST24
2157F81
5506PPP1R3A2
79837PIP4K2C2
3709ITPR25
4221MEN13
8899PRPF4B2
4067LYN3
23301EHBP13
1030CDKN2B3
3984LIMK12
8428STK245
6777STAT5B1
5932RBBP83
3977LIFR2
5915RARB4
4261CIITA3
3656IRAK22
4330MN13
23512SUZ123
444ASPH5
2122MECOM5
5087PBX15
9894TELO26
2903GRIN2A1
5925RB14
4217MAP3K53
1515CTSV5
4893NRAS6
1026CDKN1A8
7403KDM6A1
7508XPC6
112268437LOC1122684372
8841HDAC32
4302MLLT66
7040TGFB15
30849PIK3R41
3488IGFBP51
2011MARK22
79728PALB28
23092ARHGAP263
51135IRAK44
10494STK253
2261FGFR33
139604MAGEB163
3237HOXD111
5567PRKACB2
8711TNK13
55422ZNF3312
3092HIP14
4763NF12
5260PHKG13
6662SOX91
440270GOLGA8B2
94ACVRL13
2280FKBP1A3
3679ITGA73
10048RANBP95
699BUB12
27255CNTN63
83732RIOK13
4916NTRK35
2886GRB79
1795DOCK31
4486MST1R1

Gene in drug-gene network: Network Plot

Models in Fedratinib

​​​​